Results 171 to 180 of about 23,918 (199)

Cholera Toxin: Membrane Gangliosides and Activation of Adenylate Cyclase

1977
Asiatic cholera is a disease caused by the local action of a specific bacterial exotoxin on the small intestine and is characterized by a profuse outpouring of fluid at rates up to 20 liters per day (Pierce et al. 1971). The victims rapidly exhibit symptoms of hypovolemic shock, and if unassisted, may succomb within 8 hours of the onset of diarrhea ...
V. Bennett, P. Cuatrecasas
openaire   +1 more source

Bordetella extracytoplasmic adenylate cyclase: actions as a bacterial toxin.

Developments in biological standardization, 1986
Virulent Bordetella organisms produce an adenylate cyclase which is extracytoplasmic in location, activated by the eukaryotic regulatory protein, calmodulin, and able to act as a toxin, promoting cyclic AMP accumulation in target mammalian cells. Initial steps in purification of this novel adenylate cyclase toxin reveal two forms: one which possesses ...
E L, Hewlett, A A, Weiss, J K, Crane, R D, Pearson, H J, Anderson, G A, Myers, W S, Evans, L L, Hantske, H D, Kay, M J, Cronin   +9 more
openaire   +1 more source

Activation and immunogenicity of Bordetella pertussis adenylate cyclase toxin

1997
Adenylate cyclase toxin (CyaA) was produced and purified in the toxic CyaC-modified form and the unmodified non-toxic form from both B. pertussis and recombinant E. coli strains in sufficient quantity to allow large scale experimentation. Immunoblot analysis of crude and purified CyaA preparations revealed that the toxins were prepared as full length ...
openaire   +2 more sources

Bordetella pertussis toxin and adenylate cyclase

Trends in Pharmacological Sciences, 1983
openaire   +1 more source

Bordetella adenylate cyclase toxin signaling: Paralyzing the phagocyte

GBM Fall meeting Hamburg 2007, 2007
Peter Sebo1, Jana Kamanova1, Jiri Masin1,2, Radovan Fiser1,2, Oliver Knapp3, Jan Krusek4, Elke Maier3, Roland Benz3, Ivo Konopasek2, Basler1, Marek; Bumba1, Ladislav Osicka1, Radim;   +9 more
openaire   +1 more source

The Adenylate Cyclase Toxin of Bordetella pertussis Binds to Target Cells via the αMβ2 Integrin (Cd11b/Cd18)

Journal of Experimental Medicine, 2001
Pierre Guermonprez, Nadia KHELEF, Paola Ricciardi-Castagnoli   +2 more
exaly  

Development of activatable adenylate cyclase in the preimplantation mouse embryo and a role for cyclic AMP in blastocoel formation

Cell, 1986
Richard M Schultz
exaly  

Bordetella pertussis adenylate cyclase toxin translocation across a tethered lipid bilayer

Proceedings of the National Academy of Sciences of the United States of America, 2013
Rémi Veneziano, Claire Rossi, Alexandre Chenal   +2 more
exaly  

Bordetellaadenylate cyclase toxin: a unique combination of a pore-forming moiety with a cell-invading adenylate cyclase enzyme

Pathogens and Disease, 2015
Jiri Masin, Radim Osicka, Ladislav Bumba
exaly  

A nucleotide regulatory site for somatostatin inhibition of adenylate cyclase in S49 lymphoma cells

Nature, 1983
Klaus Aktories
exaly