G protein-regulated endocytic trafficking of adenylyl cyclase type 9
eLife, 2020 GPCRs are increasingly recognized to initiate signaling via heterotrimeric G proteins as they move through the endocytic network, but little is known about how relevant G protein effectors are localized.
André M Lazar +7 more
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Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors
Cellular Physiology and Biochemistry, 2018 Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation of adenylyl cyclase, causing an increase of the intracellular cAMP concentration, activation of the intracellular cAMP effectors protein kinase A (PKA) and
Thomas Pleli +11 more
doaj +2 more sources
Gαs, adenylyl cyclase, and their relationship to the diagnosis and treatment of depression [PDF]
Frontiers in Pharmacology, 2022 The relationship between depression, its etiology and therapy, and the cAMP signaling system have been studies for decades. This review will focus on cAMP, G proteins and adenylyl cyclase and depression or antidepressant action.
Jeffrey M. Schappi +5 more
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Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain
Nature Communications, 2018 Cyclic AMP and cGMP orchestrate a variety of cellular responses. Here, authors characterize the cGMP producing rhodopsin-guanylyl cyclase from C. anguillulae and derived adenylyl cyclase by a biochemical and structural approach which demonstrates the ...
Ulrike Scheib +9 more
doaj +2 more sources
Strategies to safely target widely expressed soluble adenylyl cyclase for contraception [PDF]
Frontiers in Pharmacology, 2022 In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate ...
Jacob Ferreira +2 more
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Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. [PDF]
PLoS Computational Biology, 2011 The ability of neurons to differentially respond to specific temporal and spatial input patterns underlies information storage in neural circuits. One means of achieving spatial specificity is to restrict signaling molecules to particular subcellular ...
Myungsook Kim +8 more
doaj +2 more sources
The role of the type 7 adenylyl cyclase isoform in alcohol use disorder and depression [PDF]
Frontiers in Pharmacology, 2022 The translation of extracellular signals to intracellular responses involves a number of signal transduction molecules. A major component of this signal transducing function is adenylyl cyclase, which produces the intracellular “second messenger,” cyclic
Boris Tabakoff +4 more
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Frontiers in Physiology, 2019 Signaling pathways of red blood cells’ (RBCs) micromechanics regulation, which are responsible for maintaining microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve as an indispensable tool
Alexey N Semenov, Evgeny A Shirshin
exaly +3 more sources
Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase
Nature Communications, 2018 It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-
Gemma Navarro +11 more
doaj +2 more sources
Central role of soluble adenylyl cyclase and cAMP in sperm physiology [PDF]
Biochimica et Biophysica Acta, 2014 Cyclic adenosine 3′,5′-monophosphate (cAMP), the first second messenger to be described, plays a central role in cell signaling in a wide variety of cell types.
Buffone, Mariano Gabriel +3 more
core +3 more sources