Results 1 to 10 of about 102,551 (256)

G protein-regulated endocytic trafficking of adenylyl cyclase type 9

eLife, 2020
GPCRs are increasingly recognized to initiate signaling via heterotrimeric G proteins as they move through the endocytic network, but little is known about how relevant G protein effectors are localized.
André M Lazar, Roshanak Irannejad, Tanya A Baldwin, Aparna B Sundaram, J Silvio Gutkind, Asuka Inoue, Carmen W Dessauer, Mark Von Zastrow   +7 more
doaj   +2 more sources

Gαs, adenylyl cyclase, and their relationship to the diagnosis and treatment of depression [PDF]

Frontiers in Pharmacology, 2022
The relationship between depression, its etiology and therapy, and the cAMP signaling system have been studies for decades. This review will focus on cAMP, G proteins and adenylyl cyclase and depression or antidepressant action.
Jeffrey M. Schappi, Jeffrey M. Schappi, Mark M. Rasenick, Mark M. Rasenick, Mark M. Rasenick, Mark M. Rasenick   +5 more
doaj   +2 more sources

Activation of Adenylyl Cyclase Causes Stimulation of Adenosine Receptors

Cellular Physiology and Biochemistry, 2018
Background/Aims: Signaling of Gs protein-coupled receptors (GsPCRs) is accomplished by stimulation of adenylyl cyclase, causing an increase of the intracellular cAMP concentration, activation of the intracellular cAMP effectors protein kinase A (PKA) and
Thomas Pleli, Antonia Mondorf, Nerea Ferreiros, Dominique Thomas, Karel Dvorak, Ricardo M. Biondi, Dagmar Meyer zu Heringdorf, Stefan Zeuzem, Gerd Geisslinger, Herbert Zimmermann, Oliver Waidmann, Albrecht Piiper   +11 more
doaj   +2 more sources

Rhodopsin-cyclases for photocontrol of cGMP/cAMP and 2.3 Å structure of the adenylyl cyclase domain

Nature Communications, 2018
Cyclic AMP and cGMP orchestrate a variety of cellular responses. Here, authors characterize the cGMP producing rhodopsin-guanylyl cyclase from C. anguillulae and derived adenylyl cyclase by a biochemical and structural approach which demonstrates the ...
Ulrike Scheib, Matthias Broser, Oana M. Constantin, Shang Yang, Shiqiang Gao, Shatanik Mukherjee, Katja Stehfest, Georg Nagel, Christine E. Gee, Peter Hegemann   +9 more
doaj   +2 more sources

Colocalization of protein kinase A with adenylyl cyclase enhances protein kinase A activity during induction of long-lasting long-term-potentiation. [PDF]

PLoS Computational Biology, 2011
The ability of neurons to differentially respond to specific temporal and spatial input patterns underlies information storage in neural circuits. One means of achieving spatial specificity is to restrict signaling molecules to particular subcellular ...
Myungsook Kim, Alan Jung Park, Robbert Havekes, Andrew Chay, Leonardo Antonio Guercio, Rodrigo Freire Oliveira, Rodrigo Freire Oliveira, Ted Abel, Kim T Blackwell   +8 more
doaj   +2 more sources

Strategies to safely target widely expressed soluble adenylyl cyclase for contraception [PDF]

Frontiers in Pharmacology, 2022
In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate ...
Jacob Ferreira, Lonny R. Levin, Jochen Buck   +2 more
doaj   +2 more sources

The role of the type 7 adenylyl cyclase isoform in alcohol use disorder and depression [PDF]

Frontiers in Pharmacology, 2022
The translation of extracellular signals to intracellular responses involves a number of signal transduction molecules. A major component of this signal transducing function is adenylyl cyclase, which produces the intracellular “second messenger,” cyclic
Boris Tabakoff, Boris Tabakoff, Paula L. Hoffman, Paula L. Hoffman, Paula L. Hoffman   +4 more
doaj   +2 more sources

The Effects of Different Signaling Pathways in Adenylyl Cyclase Stimulation on Red Blood Cells Deformability

Frontiers in Physiology, 2019
Signaling pathways of red blood cells’ (RBCs) micromechanics regulation, which are responsible for maintaining microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve as an indispensable tool
Alexey N Semenov, Evgeny A Shirshin
exaly   +3 more sources

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

Nature Communications, 2018
It is unclear whether GPCRs, G proteins and adenylyl cyclase (AC) associate through random collisions or defined pre-coupling mechanisms. Using a peptide-based approach, the authors show that heteromers of adenosine A2A and dopamine D2 receptors form pre-
Gemma Navarro, Arnau Cordomí, Verónica Casadó-Anguera, Estefanía Moreno, Ning-Sheng Cai, Antoni Cortés, Enric I. Canela, Carmen W. Dessauer, Vicent Casadó, Leonardo Pardo, Carme Lluís, Sergi Ferré   +11 more
doaj   +2 more sources

Role of soluble adenylyl cyclase in mitochondria.

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014
The soluble adenylyl cyclase (sAC) catalyzes the conversion of ATP into cyclic AMP (cAMP). Recent studies have shed new light on the role of sAC localized in mitochondria and its product cAMP, which drives mitochondrial protein phosphorylation and regulation of the oxidative phosphorylation system and other metabolic enzymes, presumably through the ...
F. Valsecchi, Csaba Konrad, G. Manfredi
semanticscholar   +4 more sources