Gαs, adenylyl cyclase, and their relationship to the diagnosis and treatment of depression [PDF]
Frontiers in Pharmacology, 2022 The relationship between depression, its etiology and therapy, and the cAMP signaling system have been studies for decades. This review will focus on cAMP, G proteins and adenylyl cyclase and depression or antidepressant action.
Jeffrey M. Schappi +5 more
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Adenylyl Cyclase in Ocular Health and Disease: A Comprehensive Review [PDF]
BiologyAdenylyl cyclases (ACs) are a group of enzymes that convert adenosine-5′-triphosphate (ATP) to cyclic adenosine 3′,5′ monophosphate (cAMP), a vital and ubiquitous signalling molecule in cellular responses to hormones and neurotransmitters. There are nine
Polly Thompson +5 more
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The role of soluble adenylyl cyclase in sensing and regulating intracellular pH. [PDF]
Pflugers ArchLi HL, Verhoeven A, Elferink RO.
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Strategies to safely target widely expressed soluble adenylyl cyclase for contraception
Frontiers in Pharmacology, 2022 In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate ...
Jacob Ferreira +2 more
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Editorial: Adenylyl cyclase isoforms as potential drug targets [PDF]
Frontiers in Pharmacology, 2022 Tarsis F. Brust +3 more
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Carbonic Anhydrase Inhibitor Modulation of Intraocular Pressure Is Independent of Soluble Adenylyl Cyclase. [PDF]
J Ocul Pharmacol Ther, 2023 Wiggins SV +5 more
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The small molecule triclabendazole decreases the intracellular level of cyclic AMP and increases resistance to stress in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2013 The Ras-adenylyl cyclase-protein kinase A nutrient-sensing pathway controls metabolism, proliferation and resistance to stress in Saccharomyces cerevisiae. The genetic disruption of this pathway increases resistance to a variety of stresses. We show here
Yong Joo Lee, Runhua Shi, Stephan N Witt
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The YHS-Domain of an Adenylyl Cyclase from Mycobacterium phlei Is a Probable Copper-Sensor Module. [PDF]
PLoS ONE, 2015 YHS-domains are small protein modules which have been proposed to bind transition-metal ions like the related TRASH-domains. They are found in a variety of enzymes including copper-transporting ATPases and adenylyl cyclases.
Jürgen Ulrich Linder
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The role of the type 7 adenylyl cyclase isoform in alcohol use disorder and depression
Frontiers in Pharmacology, 2022 The translation of extracellular signals to intracellular responses involves a number of signal transduction molecules. A major component of this signal transducing function is adenylyl cyclase, which produces the intracellular “second messenger,” cyclic
Boris Tabakoff +4 more
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