Results 131 to 140 of about 134,365 (335)

Dimerisation of the VIP receptor VIPR2 is essential to its binding VIP and Gαi proteins, and to its functions in breast cancer cells

British Journal of Pharmacology, Volume 182, Issue 15, Page 3612-3627, August 2025.
Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano, Kairi Ozasa, Teru Uehara, Rei Yokoyama, Takanobu Nakazawa, Souichi Yanamoto, Yukio Ago   +6 more
wiley   +1 more source

pH sensing via bicarbonate-regulated ‘soluble’ adenylyl cyclase (sAC)

Frontiers in Physiology, 2013
Soluble adenylyl cyclase (sAC) is a source of the second messenger cyclic adenosine 3',5' monophosphate (cAMP). sAC is directly regulated by bicarbonate (HCO3-) ions. In living cells, HCO3- ions are in nearly instantaneous equilibrium with carbon
Nawreen eRahman, Jochen eBuck, Lonny Ray Levin   +2 more
doaj   +1 more source

Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]

, 2004
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release.
Scheler, Gabriele
core   +1 more source

A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals

Advanced Healthcare Materials, Volume 14, Issue 17, July 4, 2025.
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin, Kyungtae Kim, Jaeseung Lee, Johyeon Nam, Eunha Baeg, Chaeyeon You, Hanseul Choi, Minji Kim, Chun Kee Chung, Jae Geun Kim, Jong Hyun Ahn, Miryung Han, Jibum Kim, Sungchil Yang, Sung Q Lee, Sunggu Yang   +15 more
wiley   +1 more source

An Adenylyl Cyclase-mAKAPβ Signaling Complex Regulates cAMP Levels in Cardiac Myocytes*

Journal of Biological Chemistry, 2009
Protein kinase A-anchoring proteins (AKAPs) play important roles in the compartmentation of cAMP signaling, anchoring protein kinase A (PKA) to specific cellular organelles and serving as scaffolds that assemble localized signaling cascades.
M. Kapiloff, L. Piggott, Rachna Sadana, Jinliang Li, Lorena Heredia, E. Henson, R. Efendiev, C. Dessauer   +7 more
semanticscholar   +1 more source

Light‐emitting diode irradiation targets aerobic glycolysis in cancer‐associated fibroblasts to inhibit metabolic coupling with colon cancer cells

Annals of Gastroenterological Surgery, Volume 9, Issue 4, Page 761-768, July 2025.
Blue LED irradiation targeted metabolic coupling between CAFs and colon cancer cells. Abstract Background The concepts examined in tumor metabolism research have been moving away from cancer cells themselves and the tumor microenvironment has become a focus of investigation.
Masaaki Nishi, Chiharu Nakasu, Toshiaki Yoshimoto, Takuya Tokunaga, T. Hideya Kashihara, Chie Takasu, Daichi Ishikawa, Yuma Wada, Mitsuo Shimada   +8 more
wiley   +1 more source

Structure, mechanism, and regulation of soluble adenylyl cyclases — similarities and differences to transmembrane adenylyl cyclases

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014
The second messenger cyclic adenosine 3',5'-monophosphate (cAMP) regulates a wide range of physiological processes in almost all organisms. cAMP synthesis is catalyzed by adenylyl cyclases (ACs). All ten mammalian AC isoenzymes (AC1-10) belong to AC Class III, which is defined by sequence homologies in the catalytic domains. Nevertheless, the mammalian
openaire   +3 more sources

Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

MedComm, Volume 6, Issue 7, July 2025.
TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao   +12 more
wiley   +1 more source

Functional lysophosphatidic acid receptor in bovine luteal cells 1This paper is dedicated to Prof. F.A. Leidenberger, the founder of the Institute for Hormone and Fertility Research, on the occasion of his 60th birthday.1 [PDF]

, 1997
The aim of this study was to determine whether luteal cells possess functional receptors for lysophosphatidic acid (LPA). We present evidence that [3H]LPA binds to a 38–40 kDa protein in a membrane fraction prepared from luteal cells and that this ...
Budnik, L.T, Mukhopadhyay, A.K
core   +1 more source

Soluble Adenylyl Cyclase Controls Mitochondria-dependent Apoptosis in Coronary Endothelial Cells*

Journal of Biological Chemistry, 2009
The cAMP signaling pathway plays an essential role in modulating the apoptotic response to various stress stimuli. Until now, it was attributed exclusively to the activity of the G-protein-responsive transmembrane adenylyl cyclase.
Sanjeev Kumar, S. Kostin, J. Flacke, H. Reusch, Y. Ladilov   +4 more
semanticscholar   +1 more source