Results 31 to 40 of about 134,365 (335)
Adenylyl cyclases in the digestive system [PDF]
Cellular Signalling, 2014 Adenylyl cyclases (ACs) are a group of widely distributed enzymes whose functions are very diverse. There are nine known transmembrane AC isoforms activated by Gαs. Each has its own pattern of expression in the digestive system and differential regulation of function by Ca(2+) and other intracellular signals.
Shannon Glaser +2 more
openaire +3 more sources
Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study
Biomolecules, 2020 Adenylyl cyclases (ACs) have a crucial role in many signal transduction pathways, in particular in the intricate control of cyclic AMP (cAMP) generation from adenosine triphosphate (ATP).
Elisa Frezza +2 more
doaj +1 more source
A molecular dynamics study of adenylyl cyclase: The impact of ATP and G-protein binding. [PDF]
PLoS ONE, 2018 Adenylyl cyclases (ACs) catalyze the biosynthesis of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP) and play an important role in many signal transduction pathways.
Elisa Frezza +2 more
doaj +1 more source
Metabolites, 2021 Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the Guinness World Record being 147 ...
Katherine M. Gerber +5 more
doaj +1 more source
Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian +2 more
core +1 more source
Regulation of Adenylyl Cyclase by Membrane Potential [PDF]
Journal of Biological Chemistry, 1998 Mammalian adenylyl cyclases possess 12 transmembrane-spanning domains and bear a superficial resemblance to certain classes of ion channels. Some evidence suggests that bacterial and sea urchin sperm adenylyl cyclases can be regulated by membrane depolarization. In the present study, we explored the effect of altering membrane potential on the adenylyl
Dermot M.F. Cooper +3 more
openalex +6 more sources
Cells, 2019 Adenylyl cyclase type 5 (AC5), as the principal isoform expressed in striatal medium spiny neurons (MSNs), is essential for the integration of both stimulatory and inhibitory midbrain signals that initiate from dopaminergic G protein-coupled receptor ...
Trevor B. Doyle +8 more
doaj +1 more source
Frontiers in Endocrinology, 2022 Despite great efforts, effective treatment against cancer has not yet been found. However, natural compounds such as the polyphenol resveratrol have emerged as promising preventive agent in cancer therapy.
Sonia Muñoz-López +3 more
doaj +1 more source
Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe [PDF]
, 1992 We have identified, cloned, and studied a gene, cap, encoding a protein that is associated with adenylyl cyclase in the fission yeast Schizosaccharomyces pombe.
Field, J. +6 more
core +2 more sources
Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase
Nature Chemical Biology, 2016 The prototypical second messenger cAMP regulates a wide variety of physiological processes. It can simultaneously mediate diverse functions by acting locally within independently-regulated microdomains.
Lavoisier S. Ramos-Espiritu +17 more
semanticscholar +1 more source