Results 51 to 60 of about 102,595 (300)

Structural basis of adenylyl cyclase 9 activation

Nature Communications, 2022
Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes ...
Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov   +12 more
doaj   +1 more source

Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

Frontiers in Physiology, 2022
In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely ...
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +1 more source

Modulation of sensory information processing by a neuroglobin in C. elegans [PDF]

, 2016
Sensory receptor neurons match their dynamic range to ecologically relevant stimulus intensities. How this tuning is achieved is poorly understood in most receptors. We show that in the C. elegans URX O2 sensing neurons two putative molecular O2 sensors, a neuroglobin and O2-binding soluble guanylate cyclases, work antagonistically to sculpt a slowly ...
arxiv   +1 more source

Bicarbonate Stimulated Adenylyl Cyclases [PDF]

IUBMB Life, 2004
AbstractBicarbonate ion is fundamental to the biology of all living organisms. HCO3‐ is vital to such diverse physiological processes as carbon fixation, cellular homeostasis, sperm maturation, and nucleotide synthesis. A defined subset of adenylyl cyclases identified in eukaryotes and prokaryotes are directly activated by HCO3‐.
openaire   +3 more sources

Identification of essential residues for binding and activation in the human 5-HT7(a) receptor by molecular modeling and site-directed mutagenesis

Frontiers in Behavioral Neuroscience, 2015
The human 5-HT7 receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders.We examined molecular determinants of ligand binding and G protein activation by the ...
Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Agata Antonina Rita eImpellizzeri, Matteo ePappalardo, Matteo ePappalardo, Livia eBasile, Ornella eManfra, Ornella eManfra, Ornella eManfra, Kjetil Wessel Andressen, Kjetil Wessel Andressen, Kjetil Wessel Andressen, Kurt Allen Krobert, Kurt Allen Krobert, Kurt Allen Krobert, Angela eMessina, Angela eMessina, Finn Olav eLevy, Finn Olav eLevy, Finn Olav eLevy, Salvatore eGuccione   +21 more
doaj   +1 more source

CO2/HCO3−- and Calcium-regulated Soluble Adenylyl Cyclase as a Physiological ATP Sensor*

Journal of Biological Chemistry, 2013
Background: The affinity of soluble adenylyl cyclase (sAC) for its substrate ATP suggested that it might be sensitive to fluctuations in ATP. Results: In sAC-overexpressing and glucose-responsive cells, sAC-generated cAMP reflects intracellular ATP ...
J. Zippin, Yanqiu Chen, S. G. Straub, K. Hess, Ana Diaz, Dana M Lee, P. Tso, G. Holz, G. Sharp, L. Levin, J. Buck   +10 more
semanticscholar   +1 more source

Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity.

Journal of the American Society of Nephrology, 2013
Vasopressin modulates sodium reabsorption in the collecting duct through adenylyl cyclase-stimulated cyclic AMP, which exists as multiple isoforms; the specific isoform involved in vasopressin-stimulated sodium transport is unknown.
Karl P Roos, V. Bugaj, Elena V. Mironova, J. Stockand, N. Ramkumar, S. Rees, D. Kohan   +6 more
semanticscholar   +1 more source

A Wireless Cortical Surface Implant for Diagnosing and Alleviating Parkinson's Disease Symptoms in Freely Moving Animals

Advanced Healthcare Materials, EarlyView.
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin, Kyungtae Kim, Jaeseung Lee, Johyeon Nam, Eunha Baeg, Chaeyeon You, Hanseul Choi, Minji Kim, Chun Kee Chung, Jae Geun Kim, Jong Hyun Ahn, Miryung Han, Jibum Kim, Sungchil Yang, Sung Q Lee, Sunggu Yang   +15 more
wiley   +1 more source

Type 10 Soluble Adenylyl Cyclase Is Overexpressed in Prostate Carcinoma and Controls Proliferation of Prostate Cancer Cells*

Journal of Biological Chemistry, 2012
Background: Soluble adenylyl cyclase (sAC) may be an alternative intracellular localized source of cAMP controlling proliferation. Results: sAC is overexpressed in prostate carcinoma, and inhibition of sAC leads to cell cycle arrest.
J. Flacke, H. Flacke, A. Appukuttan, R. Palisaar, J. Noldus, Brian D. Robinson, H. Peter Reusch, J. Zippin, Y. Ladilov   +8 more
semanticscholar   +1 more source

New Perspectives on Plant Adenylyl Cyclases [PDF]

Frontiers in Molecular Biosciences, 2019
It is increasingly clear that plant genomes encode numerous complex multidomain proteins that harbor functional adenylyl cyclase (AC) centers. These AC containing proteins have well-documented roles in development and responses to the environment. However, it is only for a few of these proteins that we are beginning to understand the intramolecular ...
Oziniel Ruzvidzo, Aloysius Wong, Chris Gehring   +2 more
openaire   +4 more sources