Results 51 to 60 of about 134,365 (335)
Opioid regulation of Mu receptor internalisation: relevance to the development of tolerance and dependence [PDF]
, 2010 Internalisation of the mu opioid receptor from the surface of cells is generally achieved by receptor occupancy with agonist ligands of high efficacy. However, in many situations the potent analgesic morphine fails to promote internalisation effectively ...
Lopez-Gimenez, J.F., Milligan, G.
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Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway [PDF]
, 2007 Regulation of intracellular cyclic adenosine 3',5'-monophosphate (cAMP) is integral in mediating cell growth, cell differentiation, and immune responses in hematopoietic cells. To facilitate studies of cAMP regulation we developed a BRET (bioluminescence
Collins, Julie +11 more
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Soluble adenylyl cyclase in the eye
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014 Adenylyl cyclases (ACs) are a family of enzymes which convert ATP to cAMP, an essential intermediate in many signal transduction pathways. Of the 10 AC genes in man, 9 fall into the category of transmembrane ACs (tmACs), which associate with G-protein coupled receptors (GPCRs) and are activated by forskolin.
Alan D. Marmorstein +2 more
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C-type natriuretic peptide and brain natriuretic peptide inhibit adenylyl cyclase activity: interaction with ANF-R2/ANP-C receptors [PDF]
, 1995 C-type natriuretic peptide (CNP) and brain natriuretic peptide (BNP) are members of the natriuretic peptide family, which have been shown to interact with ANP-C/ANF-R2 receptors in addition to ANP-B receptor subtypes.
Anand-Srivastava, Madhu B. +2 more
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On the roles of Mg in the activation of G proteins [PDF]
, 2010 In this review, we highlight the evolution of our knowledge about the way Mg2+ participates in the activation of heterotrimeric G proteins, beginning with its requirement in hormonal stimulation of fat cell adenylyl cyclase (1969) and ending with ...
Birnbaumer, Lutz, Zurita, Adolfo Ramón
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Expression and functions of adenylyl cyclases in the CNS
Fluids and Barriers of the CNS, 2022 AbstractAdenylyl cyclases (ADCYs), by generating second messenger cAMP, play important roles in various cellular processes. Their expression, regulation and functions in the CNS, however, remain largely unknown. In this review, we first introduce the classification and structure of ADCYs, followed by a discussion of the regulation of mammalian ADCYs ...
Karan Devasani, Yao Yao
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Bicarbonate Stimulated Adenylyl Cyclases [PDF]
IUBMB Life, 2004 AbstractBicarbonate ion is fundamental to the biology of all living organisms. HCO3‐ is vital to such diverse physiological processes as carbon fixation, cellular homeostasis, sperm maturation, and nucleotide synthesis. A defined subset of adenylyl cyclases identified in eukaryotes and prokaryotes are directly activated by HCO3‐.
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Frontiers in Physiology, 2022 In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely ...
Thomas Rossetti +8 more
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Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase [PDF]
, 1990 Large deletion and small insertion mutations in the adenylyl cyclase gene of Saccharomyces cerevisiae were used to map regions required for activation by RAS protein in vitro.
Ballester, R. +5 more
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Frontiers in Behavioral Neuroscience, 2015 The human 5-HT7 receptor is expressed in both the central nervous system and peripheral tissues and is a potential drug target in behavioral and psychiatric disorders.We examined molecular determinants of ligand binding and G protein activation by the ...
Agata Antonina Rita eImpellizzeri +21 more
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