Results 61 to 70 of about 134,365 (335)

CO2/HCO3−- and Calcium-regulated Soluble Adenylyl Cyclase as a Physiological ATP Sensor*

Journal of Biological Chemistry, 2013
Background: The affinity of soluble adenylyl cyclase (sAC) for its substrate ATP suggested that it might be sensitive to fluctuations in ATP. Results: In sAC-overexpressing and glucose-responsive cells, sAC-generated cAMP reflects intracellular ATP ...
J. Zippin, Yanqiu Chen, S. G. Straub, K. Hess, Ana Diaz, Dana M Lee, P. Tso, G. Holz, G. Sharp, L. Levin, J. Buck   +10 more
semanticscholar   +1 more source

Event Timing in Associative Learning [PDF]

, 2012
Associative learning relies on event timing. Fruit flies for example, once trained with an odour that precedes electric shock, subsequently avoid this odour (punishment learning); if, on the other hand the odour follows the shock during training, it is ...
Herz, Andreas V. M., Nehrkorn, Johannes, Tanimoto, Hiromu, Yarali, Ayse   +3 more
core   +1 more source

Adenylyl cyclase VI mediates vasopressin-stimulated ENaC activity.

Journal of the American Society of Nephrology, 2013
Vasopressin modulates sodium reabsorption in the collecting duct through adenylyl cyclase-stimulated cyclic AMP, which exists as multiple isoforms; the specific isoform involved in vasopressin-stimulated sodium transport is unknown.
Karl P Roos, V. Bugaj, Elena V. Mironova, J. Stockand, N. Ramkumar, S. Rees, D. Kohan   +6 more
semanticscholar   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements [PDF]

, 2010
Label-free biosensor technology based on dynamic mass redistribution (DMR) of cellular constituents promises to translate GPCR signaling into complex optical 'fingerprints' in real time in living cells.
Blattermann, S, Drewke, C., Gomeza, J., Hennen, S., Janssen, N., Kebig, A., Kostenis, E., Merten, N., Milligan, G., Mohr, K., Mohr-Andra, M., Muller, A., Schmidt, J., Schroder, R., Smith, N.J., Wenzel, J., Zahn, S.   +16 more
core   +1 more source

Type 10 Soluble Adenylyl Cyclase Is Overexpressed in Prostate Carcinoma and Controls Proliferation of Prostate Cancer Cells*

Journal of Biological Chemistry, 2012
Background: Soluble adenylyl cyclase (sAC) may be an alternative intracellular localized source of cAMP controlling proliferation. Results: sAC is overexpressed in prostate carcinoma, and inhibition of sAC leads to cell cycle arrest.
J. Flacke, H. Flacke, A. Appukuttan, R. Palisaar, J. Noldus, Brian D. Robinson, H. Peter Reusch, J. Zippin, Y. Ladilov   +8 more
semanticscholar   +1 more source

New Perspectives on Plant Adenylyl Cyclases [PDF]

Frontiers in Molecular Biosciences, 2019
It is increasingly clear that plant genomes encode numerous complex multidomain proteins that harbor functional adenylyl cyclase (AC) centers. These AC containing proteins have well-documented roles in development and responses to the environment. However, it is only for a few of these proteins that we are beginning to understand the intramolecular ...
Oziniel Ruzvidzo, Aloysius Wong, Chris Gehring   +2 more
openaire   +4 more sources

The bZIP transcription factor Rca1p is a central regulator of a novel CO₂ sensing pathway in yeast.

PLoS Pathogens, 2012
Like many organisms the fungal pathogen Candida albicans senses changes in the environmental CO(2) concentration. This response involves two major proteins: adenylyl cyclase and carbonic anhydrase (CA).
Fabien Cottier, Martine Raymond, Oliver Kurzai, Marianne Bolstad, Worraanong Leewattanapasuk, Claudia Jiménez-López, Michael C Lorenz, Dominique Sanglard, Libuše Váchová, Norman Pavelka, Zdena Palková, Fritz A Mühlschlegel   +11 more
doaj   +1 more source

Calcium ionophore, A23187 alters the mode of cAMP formation in wild-type S49 murine lymphoma cells [PDF]

, 1996
We examined the change in the adenylyl cyclase activity of S49 cells occurring after exposure to calcium ionophore A23187. MnCL2-stimulated adenylyl cyclase activity in membrane preparations increased by 67 ± 3% (after 24 h treatment with 0.3 μM A23187 ...
Nakamura, Jiro
core   +1 more source

Role of soluble adenylyl cyclase in the heart.

American Journal of Physiology. Heart and Circulatory Physiology, 2012
This review discusses the potential place of soluble adenylyl cyclase (sAC) in the framework of signaling in the cardiovascular system. cAMP has been studied as a critical and pleiotropic second messenger in cardiomyocytes, endothelial cells, and smooth ...
Jonathan Chen, L. Levin, J. Buck
semanticscholar   +1 more source