Results 101 to 110 of about 19,332 (219)
Heme b inhibits class III adenylyl cyclases
, 2023 Acidic lipid extracts from mouse liver, kidney, heart, brain, and lung inhibited human pseudoheterodimeric adenylyl cyclases (hACs) expressed in HEK293 cells.
Elsabbagh, S. ; https://orcid.org/ +4 more
core +1 more source
British Journal of Pharmacology, EarlyView.Background and Purpose The tandem of two‐pore‐domain potassium (K2P) channels TREK‐1 and TASK‐4 are expressed in the heart and pancreatic beta‐cells. As TREK‐1 and TASK‐4 belong to distinct subfamilies with different functional hallmarks, heteromerization of these two channels was highly unexpected.
Sven Schütte +14 more
wiley +1 more source
Diabetes, Obesity and Metabolism, EarlyView.ABSTRACT Aim During fasting, the liver undergoes coordinated metabolic adaptations to maintain systemic energy homeostasis. These adaptations are driven in part by glucagon, which promotes hepatic glucose production (HGP) and fatty acid oxidation (FAO) through mechanisms involving the transcription factor Foxo1.
Zheng Shen +9 more
wiley +1 more source
Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization
The FEBS Journal, EarlyView.PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe +6 more
wiley +1 more source
Soluble adenylyl cyclase in the eye
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014 Adenylyl cyclases (ACs) are a family of enzymes which convert ATP to cAMP, an essential intermediate in many signal transduction pathways. Of the 10 AC genes in man, 9 fall into the category of transmembrane ACs (tmACs), which associate with G-protein coupled receptors (GPCRs) and are activated by forskolin.
Lee, Yong S. +2 more
openaire +2 more sources
Photodynamics of optogenetic BLUF coupled photoactivated adenylyl cyclases (PACs)
, 2016 Optogenetics is a fast developing science that combines gene biology and optics to new research fields in neuroscience and cell biology. In the introduction a short literature update of optogenetic tools is given with some emphasis on rhodopsin and ...
Kateriya, Suneel +2 more
core +1 more source
Novel targets in headache: A narrative review
Headache: The Journal of Head and Face Pain, EarlyView.Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra +5 more
wiley +1 more source
Roles of Soluble Adenylyl Cyclase in cAMP Synthesis in Animal Cells [PDF]
, 2022 The second messenger cyclic adenosine 3′,5′-monophosphate (cAMP) synthesis is catalyzed by adenylyl cyclases (ACs). The second messenger cAMP participates in many physiological processes in cells.
Nguyen, Thi Mong Diep
core +1 more source
Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction
Obesity Reviews, EarlyView.Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey +7 more
wiley +1 more source