Results 101 to 110 of about 12,139 (230)

Analgesic effects of alpha‐2‐adrenoreceptor agonists in equine medicine: systemic, spinal, and local applications

Equine Veterinary Education, EarlyView.
Summary Alpha‐2‐adrenoreceptor agonists provide analgesia when used as sole agents but can also be used in combination with other drugs for their additive and potentially synergistic effects. Further, because of their effects on blood flow, alpha‐2‐adrenoreceptor agonists act to extend and perhaps intensify the effects of drugs, such as local ...
J. Brandly, J. R. Page, J. A. E. Hubbell, W. W. Muir III, K. Hopster   +4 more
wiley   +1 more source

Allosteric activation of the nitric oxide receptor soluble guanylate cyclase mapped by cryo-electron microscopy. [PDF]

, 2019
Soluble guanylate cyclase (sGC) is the primary receptor for nitric oxide (NO) in mammalian nitric oxide signaling. We determined structures of full-length Manduca sexta sGC in both inactive and active states using cryo-electron microscopy. NO and the sGC-
Hammel, Michal, Horst, Benjamin G, Hurley, James H, Marletta, Michael A, Morris, Kyle L, Rosenberg, Daniel J, Yokom, Adam L   +6 more
core  

An Arabidopsis thaliana leucine-rich repeat protein harbors an adenylyl cyclase catalytic center and affects responses to pathogens [PDF]

, 2019
Adenylyl cyclases (ACs) catalyze the formation of the second messenger cAMP from ATP. Here we report the characterization of an Arabidopsis thaliana leucine-rich repeat (LRR) protein (At3g14460; AtLRRAC1) as an adenylyl cyclase.
Alqurashi, May, Bianchet, Chantal, Gehring, Chris, Ntoukakis, Vardis, Pasqualini, Stefania, Quaglia, Mara, Wong, Aloysius   +6 more
core   +1 more source

Spatially compartmentalized phase regulation of a Ca2+-cAMP-PKA oscillatory circuit

eLife, 2020
Signaling networks are spatiotemporally organized to sense diverse inputs, process information, and carry out specific cellular tasks. In β cells, Ca2+, cyclic adenosine monophosphate (cAMP), and Protein Kinase A (PKA) exist in an oscillatory circuit ...
Brian Tenner, Michael Getz, Brian Ross, Donya Ohadi, Christopher H Bohrer, Eric Greenwald, Sohum Mehta, Jie Xiao, Padmini Rangamani, Jin Zhang   +9 more
doaj   +1 more source

Altered collecting duct adenylyl cyclase content in collecting duct endothelin-1 knockout mice [PDF]

, 2007
Background Endothelin-1 (ET-1) inhibition of vasopressin (AVP)-stimulated water reabsorption by the inner medullary collecting duct (IMCD) is associated with reduced cAMP accumulation.
Kevin A Strait, Peter K Stricklett, Donald E Kohan, K Tomita, K Tomita, K Tomita, SP Nadler, R Oishi, DE Kohan, Y Ge, AK Hughes, PK Stricklett, T Yang, JD Hoffert, MJ Bek, D Chabardes, C Helies-Toussaint, Cm Korbmacher, M Naruse   +18 more
core   +1 more source

GcrR in Streptococcus mutans Inhibits the Morphological Transition of Candida albicans Through Ras1–cAMP/PKA Pathway in the Cross‐Kingdom Biofilms

Molecular Oral Microbiology, EarlyView.
ABSTRACT The dual‐species biofilms formed by Streptococcus mutans and Candida albicans exhibit enhanced cariogenic potential due to the production of extracellular polysaccharides (EPSs). The response regulator GcrR in S. mutans negatively regulates EPS synthesis, but its impact on dual‐species biofilms remains unclear.
Bin Zhang, Shihao Hou, Anqi Zhang, Jielin Yang, Wenjiao Zhang, Shijie Zhu, Hong Chen, Ruizhe Huang   +7 more
wiley   +1 more source

Evolutionary adaptation of the essential tRNA methyltransferase TrmD to the signaling molecule 3,5-cAMP in bacteria. [PDF]

, 2016
The nucleotide signaling molecule 3',5'-cyclic adenosine monophosphate (3',5'-cAMP) plays important physiological roles, ranging from carbon catabolite repression in bacteria to mediating the action of hormones in higher eukaryotes, including human ...
Agrebi, R, Bellows, LE, Collet, JF, Gründling, A, Kaever, V, Zhang, Y   +5 more
core   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

Activity of Cyclic AMP Phosphodiesterases and Adenylyl Cyclase in Peripheral Nerve after Crush and Permanent Transection Injuries [PDF]

, 1998
Recent studies demonstrate that cAMP levels are tightly controlled during demyelination and remyelination in Schwann cells as cAMP decreases to 8–10% of normal following both sciatic nerve crush or permanent transection injury and only begins to increase
Poduslo, Joseph F., Walikonis, Randall S.   +1 more
core   +1 more source

Mitochondrial control of ciliary gene expression and structure in striatal neurons

The Journal of Physiology, EarlyView.
Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen, Alessandro Chioino, Olivia Zanoletti, Albert Quintana, Elisenda Sanz, Carmen Sandi   +5 more
wiley   +1 more source