Results 101 to 110 of about 8,032 (234)

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization

The FEBS Journal, EarlyView.
PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe, Jiawei Xing, Xiansha Xiao, John A. Buglino, Huilin Li, Igor B. Zhulin, Michael S. Glickman   +6 more
wiley   +1 more source

Malaria mosquito antimicrobial defence requires immunity and detoxification gene regulation by Lola

Insect Molecular Biology, EarlyView.
Malaria mosquito antimicrobial defence requires upregulation of lola. Attenuation of lola in the midgut of Anopheles albimanus mosquitoes inhibits the upregulation of immunity genes induced by challenge. Putative target genes of the Lola transcription factor were revealed by lola attenuation, including Cecropin‐C, Draper, PPAF2, Clip‐domain serine ...
Heidi Espadas‐Álvarez, Verónica Valverde‐Garduño   +1 more
wiley   +1 more source

Ciliary adenylyl cyclases control the Hedgehog pathway

, 2016
Protein kinase A (PKA) accumulates at the base of the cilium where it negatively regulates the Hedgehog (Hh) pathway. Although PKA activity is essentially controlled by the cAMP produced by adenylyl cyclases, the influence of these enzymes on the Hh ...
Pons, Sebastián, Torroba, Blanca, Menendez, Anghara, Vuolo, Laura, Herrera, Antonio   +4 more
core   +1 more source

The complex of TRIP-Br1 and XIAP ubiquitinates and degrades multiple adenylyl cyclase isoforms

eLife, 2017
Adenylyl cyclases (ACs) generate cAMP, a second messenger of utmost importance that regulates a vast array of biological processes in all kingdoms of life.
Wenbao Hu, Xiaojie Yu, Zhengzhao Liu, Ying Sun, Xibing Chen, Xin Yang, Xiaofen Li, Wai Kwan Lam, Yuanyuan Duan, Xu Cao, Hermann Steller, Kai Liu, Pingbo Huang   +12 more
doaj   +1 more source

Characterization and engineering of photoactivated adenylyl cyclases [PDF]

, 2019
Cyclic nucleoside monophosphates (cNMP) serve as universal second messengers in signal transduction across prokaryotes and eukaryotes. As signaling often relies on transiently formed microdomains of elevated second messenger concentration, means to ...
Stabel, Robert, Stüven, B., Möglich, A., Stüven, Birthe, Ohlendorf, Robert, Ohlendorf, R. ; https://orcid.org/, Schubert, Roman, Beck, J., Beck, Julian, Schubert, R., Möglich, Andreas, Stabel, R.   +11 more
core   +1 more source

Role of canonical and non-canonical cAMP sources in CRHR2α-dependent signaling.

PLoS ONE
Hippocampal neurons exhibit activation of both the conventional transmembrane adenylyl cyclases (tmACs) and the non-canonical soluble adenylyl cyclase (sAC) as sources of cyclic AMP (cAMP). These two cAMP sources play crucial roles in mediating signaling
Natalia G Armando, Paula A Dos Santos Claro, Mariana Fuertes, Eduardo Arzt, Susana Silberstein   +4 more
doaj   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

GcrR in Streptococcus mutans Inhibits the Morphological Transition of Candida albicans Through Ras1–cAMP/PKA Pathway in the Cross‐Kingdom Biofilms

Molecular Oral Microbiology, EarlyView.
ABSTRACT The dual‐species biofilms formed by Streptococcus mutans and Candida albicans exhibit enhanced cariogenic potential due to the production of extracellular polysaccharides (EPSs). The response regulator GcrR in S. mutans negatively regulates EPS synthesis, but its impact on dual‐species biofilms remains unclear.
Bin Zhang, Shihao Hou, Anqi Zhang, Jielin Yang, Wenjiao Zhang, Shijie Zhu, Hong Chen, Ruizhe Huang   +7 more
wiley   +1 more source

Functional characterization of transmembrane adenylyl cyclases from the honeybee brain

, 2012
Balfanz S, Ehling P, Wachten S, et al. Functional characterization of transmembrane adenylyl cyclases from the honeybee brain. Insect Biochemistry and Molecular Biology.
Mujagic, S., Balfanz, Sabine, Baumann, A., Ehling, P., Wachten, S., Jordan, Nadine, Baumann, Arnd, Erber, J., Wachten, Sebastian, Ehling, Petra, Erber, Joachim, Jordan, N., Mujagic, Samir, Balfanz, S.   +13 more
core   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source