Results 91 to 100 of about 18,703 (229)

The ESAG4 sub-family of adenylyl cyclases is required for cytokinesis of Trypanosoma brucei bloodstream forms

, 2011
ESAG4 sub-family of adenylyl cyclases of Trypanosoma ...

core  

Incretin‐Based Therapies as Cardiometabolic Interventions: Outcome Hierarchy, Receptor‐Network Pharmacology and Phenotype‐Based Clinical Positioning

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Incretin‐based pharmacotherapy was initially developed to improve glucose‐dependent insulin secretion and glycaemic control in type 2 diabetes, but its clinical interpretation has expanded substantially with cardiovascular outcome trials, kidney outcome data, obesity studies and next‐generation polyagonist development.
Ferenc Sztanek, Hajnalka Lőrincz, Mariann Harangi, Attila Csaba Nagy   +3 more
wiley   +1 more source

Soluble adenylyl cyclase in the eye

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014
Adenylyl cyclases (ACs) are a family of enzymes which convert ATP to cAMP, an essential intermediate in many signal transduction pathways. Of the 10 AC genes in man, 9 fall into the category of transmembrane ACs (tmACs), which associate with G-protein coupled receptors (GPCRs) and are activated by forskolin.
Lee, Yong S., Marmorstein, Lihua Y., Marmorstein, Alan D.   +2 more
openaire   +2 more sources

Ligand binding represses bacterial histidine kinase activity by inhibiting its dimerization

The FEBS Journal, EarlyView.
PdtaS is a kinase in the pathogen Mycobacterium tuberculosis that senses copper and nitric oxide and controls virulence gene expression, but how the kinase senses these compounds was unclear. We show that PdtaS is active as a dimer with each monomer phosphorylating the other in trans.
Gaurav D. Sankhe, Jiawei Xing, Xiansha Xiao, John A. Buglino, Huilin Li, Igor B. Zhulin, Michael S. Glickman   +6 more
wiley   +1 more source

Novel targets in headache: A narrative review

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This narrative review summarizes novel applications for the use of calcitonin gene‐related peptide (CGRP)‐targeted therapies that go beyond migraine, the latest updates with respect to targeting pituitary adenylate cyclase‐activating peptide (PACAP) as therapeutic in migraine, as well as exploring other more recently ...
Adriana Della Pietra, Peter J. Goadsby, Carolina Oldoni, Stephen Silberstein, Fred Cohen, Simon Akerman   +5 more
wiley   +1 more source

Mycobacterial adenylyl cyclases: Biochemical diversity and structural plasticity [PDF]

, 2006
The conversion of adenine and guanine nucleoside triphosphates to cAMP and cGMP is carried out by nucleotide cyclases, which vary in their primary sequence and are therefore grouped into six classes.
Shenoy, Avinash R., Shenoy, Avinash R, Sandhya S. Visweswariah, Visweswariah, Sandhya S., Visweswariah, Sandhya S, Avinash R. Shenoy   +5 more
core   +2 more sources

Heme b inhibits class III adenylyl cyclases

, 2023
Acidic lipid extracts from mouse liver, kidney, heart, brain, and lung inhibited human pseudoheterodimeric adenylyl cyclases (hACs) expressed in HEK293 cells.
Elsabbagh, S. ; https://orcid.org/, Landau, M., Gross, H., Schultz, A., Schultz, J.   +4 more
core   +1 more source

Innovations in Obesity Treatment: Beyond Adipose Tissue Dysfunction

Obesity Reviews, EarlyView.
Obesity drives chronic inflammation, insulin resistance, type 2 diabetes, and cancer development through adipocyte dysfunction. Addressing this multisystemic disorder requires integrated strategies beyond diet and exercise, such as thermogenesis activation via menthol or capsinoids and appetite control through GLP‐1/GIP agonists and neuromodulation to ...
Jesica Martínez‐Godfrey, Irene Pomares‐Bri, Paula de Juan‐Maciá, Mariló Olivares‐Vicente, Enrique Barrajón‐Catalán, Vicente Micol, Enrique Roche, María Herranz‐López   +7 more
wiley   +1 more source

Biochemical properties of heterologously expressed and native adenylyl cyclases from the honeybee brain (Apis mellifera L.)

, 2010
Fuss N, Mujagic S, Erber J, Wachten S, Baumann A. Biochemical properties of heterologously expressed and native adenylyl cyclases from the honeybee brain (Apis mellifera L.). Insect Biochem.Mol.Biol.
Nadine Fuss, Joachim Erber, Mujagic, S., Sebastian Wachten, Baumann, A., Wachten, S., Fuss, N., Baumann, Arnd, Erber, J., Arnd Baumann, Wachten, Sebastian, Samir Mujagic, Erber, Joachim, Fuss, Nadine, Mujagic, Samir   +14 more
core   +1 more source

MdPHYB2‐MdPIF1 Module Regulates Transcription Factors to Mediate Light‐Dependent ALA‐Induced Apple Anthocyanin Biosynthesis

Plant, Cell &Environment, EarlyView.
ABSTRACT Light is a primary environmental signal that induces plant anthocyanin accumulation. The plant growth regulator 5‐aminolevulinic acid (ALA) has also been proven to effectively promote anthocyanin accumulation in apple. However, the underlying regulatory mechanisms remain unknown.
Liuzi Zhang, Yuyan An, Jianting Zhang, Liangju Wang   +3 more
wiley   +1 more source