Results 81 to 90 of about 19,332 (219)
Regulation of Adenylyl Cyclase by Membrane Potential [PDF]
Journal of Biological Chemistry, 1998 Mammalian adenylyl cyclases possess 12 transmembrane-spanning domains and bear a superficial resemblance to certain classes of ion channels. Some evidence suggests that bacterial and sea urchin sperm adenylyl cyclases can be regulated by membrane depolarization. In the present study, we explored the effect of altering membrane potential on the adenylyl
Cooper, Dermot M. F. +3 more
openaire +5 more sources
Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide [PDF]
, 2009 Carbon dioxide is fundamental to the physiology of all organisms. There is considerable interest in the precise molecular mechanisms that organisms use to directly sense CO2.
Holliday, PM +6 more
core +1 more source
A defined subset of adenylyl cyclases is regulated by bicarbonate ion [PDF]
, 2003 The molecular basis by which organisms detect and respond to fluctuations in inorganic carbon is not known. The cyaB1 gene of the cyanobacterium Anabaena sp.
Cann, M.J. +3 more
core +1 more source
iNew Medicine, EarlyView.This review highlights hepatocytes as active regulators of MASH fibrosis through secreted proteins, metabolites, and extracellular vesicles that modulate hepatic stellate cell activation. These hepatocyte–stellate cell communication pathways provide a mechanistic framework for developing targeted antifibrotic therapies, including hepatocyte‐directed ...
Eui Jung Jung, Xiaobo Wang
wiley +1 more source
Cells, 2021 The vascular hypothesis used to explain the pathophysiology of Alzheimer’s disease (AD) suggests that a dysfunction of the cerebral microvasculature could be the beginning of alterations that ultimately leads to neuronal damage, and an abnormal increase ...
Dolores Viña +3 more
doaj +1 more source
6‐Nitrodopamine as a Novel Mediator of Prostatic Smooth Muscle Function in Mouse and Human
Andrology, EarlyView.ABSTRACT Background Epithelium‐derived catecholamines contribute to local regulation of genitourinary smooth muscle function, but the role of the endogenous 6‐nitrodopamine (6‐ND) in the prostate remains unknown. Objectives To determine whether 6‐ND is produced by mouse and human prostate and its role in smooth muscle regulation.
Alline Araujo Curiel +12 more
wiley +1 more source
Fungal adenylyl cyclases contain multiple domains acting as sensors for a diverse range of signals.
, 2013 Evidence from many studies of the past decade or so supports a model in which fungal adenylyl cyclases function as a hub of signal sensing and integration. This figure illustrates all the conserved domains in fungal adenylyl cyclases and the external and
Yue Wang (65477)
core +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
, 2013 Primers and reaction conditions used for amplification of adenylyl cyclases, opioid receptors and GAPDH in human breast cancer cells.
Hermann Ammer (290430) +2 more
core +1 more source
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source