Results 61 to 70 of about 8,032 (234)

The regulation of stem cell fate and its application in neural regeneration

Interdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He, Xingyu Chen, Minghong He, Zhe Li   +3 more
wiley   +1 more source

cAMP-dependent cell differentiation triggered by activated CRHR1 in hippocampal neuronal cells

Scientific Reports, 2017
Corticotropin-releasing hormone receptor 1 (CRHR1) activates the atypical soluble adenylyl cyclase (sAC) in addition to transmembrane adenylyl cyclases (tmACs).
Carolina Inda, Juan José Bonfiglio, Paula A. dos Santos Claro, Sergio A. Senin, Natalia G. Armando, Jan M. Deussing, Susana Silberstein   +6 more
doaj   +1 more source

The genetically encoded tool set for investigating cAMP: more than the sum of its parts

Frontiers in Pharmacology, 2015
Intracellular fluctuations of the second messenger cyclic AMP (cAMP) are regulated with spatial and temporal precision. This regulation is supported by the sophisticated arrangement of cyclases, phosphodiesterases, anchoring proteins and receptors for ...
Neha ePatel, Matthew G Gold
doaj   +1 more source

Regulation of Adenylyl Cyclase by Membrane Potential [PDF]

Journal of Biological Chemistry, 1998
Mammalian adenylyl cyclases possess 12 transmembrane-spanning domains and bear a superficial resemblance to certain classes of ion channels. Some evidence suggests that bacterial and sea urchin sperm adenylyl cyclases can be regulated by membrane depolarization. In the present study, we explored the effect of altering membrane potential on the adenylyl
Cooper, Dermot M. F., Schell, Michael J., Thorn, Peter, Irvine, Robin F.   +3 more
openaire   +5 more sources

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

Medicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang, Changling Xu, Jiangang Fan, Renjie Chai   +3 more
wiley   +1 more source

Photodynamics of optogenetic BLUF coupled photoactivated adenylyl cyclases (PACs)

, 2016
Optogenetics is a fast developing science that combines gene biology and optics to new research fields in neuroscience and cell biology. In the introduction a short literature update of optogenetic tools is given with some emphasis on rhodopsin and ...
Kateriya, Suneel, Penzkofer, Alfons, Hegemann, Peter   +2 more
core   +1 more source

CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans. [PDF]

, 2010
When colonising host-niches or non-animated medical devices, individual cells of the fungal pathogen Candida albicans expand into significant biomasses. Here we show that within such biomasses, fungal metabolically generated CO(2) acts as a communication
Topal Hüsnü, Maccallum, Donna M., Hall, Rebecca, Fritz A. Mühlschlegel, Gow, Neil A R, Hall, Rebecca A., Rebecca A Hall, Bloor, JW, Bloor James W., Neil A. R. Gow, Steegborn Clemens, James W, Bloor, James W., Muehlschlegel, Fritz A, Rebecca A. Hall, Buck, Jochen, Hall, RA, Wang Yue, Gow, Neil A. R., Hüsnü Topal, Hall Rebecca A., Buck Jochen, Fritz A Mühlschlegel, Eaton Rebecca, Wang, Yue, Donna M. Maccallum, Mühlschlegel Fritz A., MacCallum, Donna M, De Sordi, Luisa, Levin Lonny R., Gary K Robinson, Jochen Buck, Maccallum, DM, James W. Bloor, Steegborn, Clemens, Neil A R Gow, Topal, Husnu, Mühlschlegel, Fritz A, MacCallum Donna M., Eaton, R, De Sordi, L, Levin, LR, Gary K. Robinson, Steegborn, C, Rebecca Eaton, Luisa De Sordi, Mühlschlegel, FA, Clemens Steegborn, Robinson, GK, Lonny R Levin, Mühlschlegel, Fritz A., De Sordi Luisa, Wang, Y, Levin, Lonny R., Gow Neil A. R., Donna M Maccallum, Levin, Lonny R, Topal, Huesnue, Topal, H, Robinson, Gary K, Gow, NA, Lonny R. Levin, Eaton, Rebecca, James W Bloor, Hall, Rebecca; id_orcid, Bloor, James W, Robinson Gary K., Buck, J, Yue Wang, Robinson, Gary K.   +69 more
core   +1 more source

Heme b inhibits class III adenylyl cyclases

, 2023
Acidic lipid extracts from mouse liver, kidney, heart, brain, and lung inhibited human pseudoheterodimeric adenylyl cyclases (hACs) expressed in HEK293 cells.
Elsabbagh, S. ; https://orcid.org/, Landau, M., Gross, H., Schultz, A., Schultz, J.   +4 more
core   +1 more source

Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice.

PLoS ONE, 2008
BackgroundMammalian Soluble adenylyl cyclase (sAC, Adcy10, or Sacy) represents a source of the second messenger cAMP distinct from the widely studied, G protein-regulated transmembrane adenylyl cyclases.
Jeanne Farrell, Lavoisier Ramos, Martin Tresguerres, Margarita Kamenetsky, Lonny R Levin, Jochen Buck   +5 more
doaj   +1 more source

Distinct Brain Drivers and Shared Cerebello–Cortical Input in ADCY5 and SGCE Hyperkinetic Movements

Movement Disorders, EarlyView.
Resting‐state fMRI and effective connectivity revealed distinct cerebellar–basal ganglia–cortical interactions in ADCY5 (MxMD‐ADCY5) and SGCE (MYC/DYT‐SGCE) related movement disorders. The cerebellum modulated cortex directly in MYC/DYT‐SGCE, but indirectly via basal ganglia‐cerebellar projections in MxMD‐ADCY5, which also showed reduced subthalamic ...
Clément Tarrano, Cécile Galléa, Asya Ekmen, Cécile Delorme, Eavan M. McGovern, Quentin Salardaine, Lina Daghsen, Manon Gomes, Vanessa Brochard, Eoin Mulroy, Kailash P. Bhatia, Carlo Fusco, Miryam Carecchio, Norbert Brüggemann, Alexander Münchau, Victoria Gonzalez, Diane Doummar, Christine Tranchant, Mathieu Anheim, Philippe Damier, Florence Riant, Mohamed Doulazmi, Agathe Roubertie, Caroline Dubacq, Oriane Trouillard, Romain Valabregue, Mélanie Didier, Benoit Beranger, Pierre Pouget, Marie Vidailhet, Sabine Meunier, Aurélie Méneret, Yulia Worbe, Emmanuel Roze   +33 more
wiley   +1 more source