Fungal Adenylyl Cyclase Acts As a Signal Sensor and Integrator and Plays a Central Role in Interaction with Bacteria [PDF]
, 2013 10.1371/journal.ppat.1003612PLoS ...
A Davis-Hanna +28 more
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Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2 [PDF]
PeerJ, 2015 GAF domains are a large family of regulatory domains, and a subset are found associated with enzymes involved in cyclic nucleotide (cNMP) metabolism such as adenylyl cyclases and phosphodiesterases.
Kabir Hassan Biswas +4 more
doaj +2 more sources
Genetic disruption of the core circadian clock impairs hippocampus-dependent memory [PDF]
, 2014 Perturbing the circadian system by electrolytically lesioning the suprachiasmatic nucleus (SCN) or varying the environmental light:dark schedule impairs memory, suggesting that memory depends on the circadian system.
Chen, Xuanmao +4 more
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Stimulation of electro-olfactogram responses in the main olfactory epithelia by airflow depends on the type 3 adenylyl cyclase [PDF]
, 2012 Cilia of olfactory sensory neurons are the primary sensory organelles for olfaction. The detection of odorants by the main olfactory epithelium (MOE) depends on coupling of odorant receptors to the type 3 adenylyl cyclase (AC3) in olfactory cilia.
Chen, Xuanmao +2 more
core +2 more sources
Cells, 2021 P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates Rac-type small G proteins in response to the stimulation of a range of receptors, particularly G protein-coupled receptors (GPCRs), to control cytoskeletal dynamics and other Rac ...
Elizabeth Hampson +6 more
doaj +1 more source
Role of cAMP Signaling in the Survival and Infectivity of the Protozoan Parasite, Leishmania donovani [PDF]
, 2011 Leishmania donovani, while invading macrophages, encounters striking shift in temperature and pH (from 22◦ C and pH 7.2 to 37◦ C and pH 5.5), which act as the key environmental trigger for differentiation, and increases cAMP level and cAMP-mediated ...
Biswas, Arumina +2 more
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Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection. [PDF]
PLoS Pathogens, 2008 Malaria starts with the infection of the liver of the host by Plasmodium sporozoites, the parasite form transmitted by infected mosquitoes. Sporozoites migrate through several hepatocytes by breaching their plasma membranes before finally infecting one ...
Takeshi Ono +10 more
doaj +1 more source
An entropy based heuristic model for predicting functional sub-type divisions of protein families [PDF]
, 2009 Multiple sequence alignments of protein families are often used for locating residues that are widely apart in the sequence, which are considered as influential for determining functional specificity of proteins towards various substrates, ligands, DNA ...
Bakis, Yasin +5 more
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Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. [PDF]
PLoS ONE, 2016 In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide ...
Serge Goupil +5 more
doaj +1 more source
Guanylyl cyclase activity associated with putative bifunctional integral membrane proteins in Plasmodium falciparum. [PDF]
, 2000 We report here that guanylyl cyclase activity is associated with two large integral membrane proteins (PfGCalpha and PfGCbeta) in the human malaria parasite Plasmodium falciparum.
Altschul +52 more
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