Results 41 to 50 of about 8,032 (234)

Hypoxia induces cancer-associated cAMP/PKA signalling through HIF-mediated transcriptional control of adenylyl cyclases VI and VII. [PDF]

Sci Rep, 2017
Hypoxia is a phenomenon often arising in solid tumours, linked to aggressive malignancy, bad prognosis and resistance to therapy. Hypoxia-inducible factor-1 has been identified as a key mediator of cell and tissue adaptation to hypoxic conditions through
Simko V, Iuliano F, Sevcikova A, Labudova M, Barathova M, Radvak P, Pastorekova S, Pastorek J, Csaderova L.   +8 more
europepmc   +2 more sources

P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cells

Cells, 2021
P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates Rac-type small G proteins in response to the stimulation of a range of receptors, particularly G protein-coupled receptors (GPCRs), to control cytoskeletal dynamics and other Rac ...
Elizabeth Hampson, Elpida Tsonou, Martin J. Baker, David C. Hornigold, Roderick E. Hubbard, Andrew Massey, Heidi C. E. Welch   +6 more
doaj   +1 more source

Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection. [PDF]

PLoS Pathogens, 2008
Malaria starts with the infection of the liver of the host by Plasmodium sporozoites, the parasite form transmitted by infected mosquitoes. Sporozoites migrate through several hepatocytes by breaching their plasma membranes before finally infecting one ...
Takeshi Ono, Laura Cabrita-Santos, Ricardo Leitao, Esther Bettiol, Lisa A Purcell, Olga Diaz-Pulido, Lucy B Andrews, Takushi Tadakuma, Purnima Bhanot, Maria M Mota, Ana Rodriguez   +10 more
doaj   +1 more source

A defined subset of adenylyl cyclases is regulated by bicarbonate ion [PDF]

, 2003
The molecular basis by which organisms detect and respond to fluctuations in inorganic carbon is not known. The cyaB1 gene of the cyanobacterium Anabaena sp.
Cann, M.J., Hammer, A., Kanacher, T., Zhou, J.   +3 more
core   +1 more source

Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. [PDF]

PLoS ONE, 2016
In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide ...
Serge Goupil, Loïze Maréchal, Hassan El Hajj, Marie-Ève Tremblay, François J Richard, Pierre Leclerc   +5 more
doaj   +1 more source

The Dictyostelium discoideum acaA gene is transcribed from alternative promoters during aggregation and multicellular development. [PDF]

PLoS ONE, 2010
BACKGROUND: Extracellular cAMP is a key extracellular signaling molecule that regulates aggregation, cell differentiation and morphogenesis during multi-cellular development of the social amoeba Dictyostelium discoideum.
Maria Galardi-Castilla, Ane Garciandía, Teresa Suarez, Leandro Sastre   +3 more
doaj   +1 more source

Raf kinase activation of adenylyl cyclases: isoform-selective regulation [PDF]

, 2020
Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. The activity of adenylyl cyclase is stimulated by a range of hormone receptors, primarily via interactions with G ...
Robert Gros, Ronald Taussig, Ross D Feldman, Stephen S G Ferguson, Qingming Ding, Ian D Gray   +5 more
core  

High throughput screening for chemical inhibitors of mammalian adenylyl cyclases expressed in fission yeast

, 2020
The poster describes our research to identify cell-permeable small molecule inhibitors of mammalian transmembrane adenylyl cyclases expressed in the fission yeast Schizosaccharomyces pombe.Video walkthrough of poster 581B describing HTSs to identify ...
Sheng Xiang Huang (8708677), Juliane Dessalines (8708680), James Inglese (5824572), Patricia K. Dranchak (6919664), Jeremy Eberhard (8708679), Nicholas Ollila (8708681), Harrison Silva (8708682), Charles Hoffman (8708674)   +7 more
core   +1 more source

Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling in Dictyostelium

Cells
Dictyostelium is a unique model used to study the complex and interactive cyclic nucleotide signaling pathways that regulate multicellular development.
Pundrik Jaiswal, Alan R. Kimmel
doaj   +1 more source

Regulation of prokaryotic adenylyl cyclases by CO₂

, 2006
The Slr1991 adenylyl cyclase of the model prokaroyte Synechocystis PCC 6803 was stimulated 2-fold at 20 mM total Ci (inorganic carbon) atpH 7.5 through an increase in kcat.Adose response demonstrated an EC50 of 52.7 mMtotal Ci at pH 6.5. Slr1991 adenylyl
Hodgson, David Rw, Hammer, A., Cann, M.J., Hammer, Arne, Cann, Martin J, Hodgson, D.R.W.   +5 more
core   +1 more source