Results 31 to 40 of about 19,332 (219)

Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases. [PDF]

Cell Chem Biol, 2019
Because small-molecule activators of adenylyl cyclases (AC) affect ACs cell-wide, it is challenging to explore the signaling consequences of AC activity emanating from specific intracellular compartments.
O'Banion CP, Vickerman BM, Haar L, Lawrence DS.   +3 more
europepmc   +2 more sources

Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells. [PDF]

J Biol Chem, 2018
Class III adenylyl cyclases generate the ubiquitous second messenger cAMP from ATP often in response to environmental or cellular cues. During evolution, soluble adenylyl cyclase catalytic domains have been repeatedly juxtaposed with signal-input domains
Blain-Hartung M, Rockwell NC, Moreno MV, Martin SS, Gan F, Bryant DA, Lagarias JC.   +6 more
europepmc   +2 more sources

Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

Frontiers in Physiology, 2022
In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely ...
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +1 more source

Structural basis of adenylyl cyclase 9 activation

Nature Communications, 2022
Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes ...
Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov   +12 more
doaj   +1 more source

Adenylyl cyclases (ACs) in GtoPdb v.2023.1 [PDF]

, 2023
Adenylyl cyclase, E.C. 4.6.1.1, converts ATP to cyclic AMP and pyrophosphate. Mammalian membrane-delimited adenylyl cyclases (nomenclature as approved by the NC-IUPHAR Subcommittee on Adenylyl cyclases [11]) are typically made up of two clusters of six ...
Watts, Val J., Carmen W. Dessauer, Rennolds Ostrom, Seifert, Roland, Roland Seifert, Val J. Watts, Dessauer, Carmen W., Ostrom, Rennolds   +7 more
core   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Adenylyl Cyclases as Therapeutic Targets in Neuroregeneration. [PDF]

Int J Mol Sci
Adenylyl cyclases (ACs) are key regulators of cyclic adenosine monophosphate (cAMP) signaling—a pathway critical for neuroregeneration, synaptic plasticity, and neuronal survival.
Tomczak J, Kapsa A, Boczek T.
europepmc   +2 more sources

cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes. [PDF]

Mol Pharmacol, 2018
It is widely accepted that cAMP signaling is compartmentalized within cells. However, our knowledge of how receptors, cAMP signaling enzymes, effectors and other key proteins form specific signaling complexes to regulate specific cell responses is ...
Johnstone TB, Agarwal SR, Harvey RD, Ostrom RS.   +3 more
europepmc   +2 more sources

The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected].. [PDF]

PLoS ONE, 2013
Adenosine 3', 5'-cyclic monophosphate (cAMP) and guanosine 3', 5'-cyclic monophosphate (cGMP) are well-studied second messengers that transmit extracellular signals into mammalian cells, with conserved functions in various other species such as ...
Ulrike Beckert, Wen Yih Aw, Heike Burhenne, Lisa Försterling, Volkhard Kaever, Lisa Timmons, Roland Seifert   +6 more
doaj   +1 more source

AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels

Function, 2021
To ensure specificity of response, eukaryotic cells often restrict signalling molecules to sub-cellular regions. The Ca2+ nanodomain is a spatially confined signal that arises near open Ca2+ channels.
Pulak Kar, Pradeep Barak, Anna Zerio, Yu-Ping Lin, Amy J Parekh, Val J Watts, Dermot M F Cooper, Manuela Zaccolo, Holger Kramer, Anant B Parekh   +9 more
doaj   +1 more source