Results 21 to 30 of about 12,139 (230)

The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected].. [PDF]

PLoS ONE, 2013
Adenosine 3', 5'-cyclic monophosphate (cAMP) and guanosine 3', 5'-cyclic monophosphate (cGMP) are well-studied second messengers that transmit extracellular signals into mammalian cells, with conserved functions in various other species such as ...
Ulrike Beckert, Wen Yih Aw, Heike Burhenne, Lisa Försterling, Volkhard Kaever, Lisa Timmons, Roland Seifert   +6 more
doaj   +1 more source

AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels

Function, 2021
To ensure specificity of response, eukaryotic cells often restrict signalling molecules to sub-cellular regions. The Ca2+ nanodomain is a spatially confined signal that arises near open Ca2+ channels.
Pulak Kar, Pradeep Barak, Anna Zerio, Yu-Ping Lin, Amy J Parekh, Val J Watts, Dermot M F Cooper, Manuela Zaccolo, Holger Kramer, Anant B Parekh   +9 more
doaj   +1 more source

A molecular dynamics study of adenylyl cyclase: The impact of ATP and G-protein binding. [PDF]

PLoS ONE, 2018
Adenylyl cyclases (ACs) catalyze the biosynthesis of cyclic adenosine monophosphate (cAMP) from adenosine triphosphate (ATP) and play an important role in many signal transduction pathways.
Elisa Frezza, Juliette Martin, Richard Lavery   +2 more
doaj   +1 more source

Allosteric Inhibition of Adenylyl Cyclase Type 5 by G-Protein: A Molecular Dynamics Study

Biomolecules, 2020
Adenylyl cyclases (ACs) have a crucial role in many signal transduction pathways, in particular in the intricate control of cyclic AMP (cAMP) generation from adenosine triphosphate (ATP).
Elisa Frezza, Tina-Méryl Amans, Juliette Martin   +2 more
doaj   +1 more source

The YHS-Domain of an Adenylyl Cyclase from Mycobacterium phlei Is a Probable Copper-Sensor Module. [PDF]

PLoS ONE, 2015
YHS-domains are small protein modules which have been proposed to bind transition-metal ions like the related TRASH-domains. They are found in a variety of enzymes including copper-transporting ATPases and adenylyl cyclases.
Jürgen Ulrich Linder
doaj   +1 more source

Molecular, Enzymatic, and Cellular Characterization of Soluble Adenylyl Cyclase From Aquatic Animals. [PDF]

, 2018
The enzyme soluble adenylyl cyclase (sAC) is the most recently identified source of the messenger molecule cyclic adenosine monophosphate. sAC is evolutionarily conserved from cyanobacteria to human, is directly stimulated by [Formula: see text] ions ...
Acin-Perez, Barott, Barott, Barott, Beltrán, Berthelot, Bitterman, Bordeaux, Braun, Braun, Braun, Buck, Camacho Londoño, Chaloupka, Chen, Chen, Cooper, De Rasmo, Di Benedetto, Elliott, Farrell, Geng, Goldberg, Gordeladze, Hess, Hrdlickova, Jaiswal, Kobayashi, Leparc, Levin, Litvin, Magro, Neer, Neer, Nomura, Nomura, Ramos-Espiritu, Roa, Roa, Roa, Salem, Salomon, Schwencke, Steegborn, Steegborn, Stessin, Structural Genomics Consortium, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Wilson, Yeo, Zaccolo, Zippin, Zippin, Zippin, Zippin   +58 more
core   +2 more sources

Overexpression of the type 1 adenylyl cyclase in the forebrain leads to deficits of behavioral inhibition [PDF]

, 2015
The type 1 adenylyl cyclase (AC1) is an activity-dependent, calcium-stimulated adenylyl cyclase expressed in the nervous system that is implicated in memory formation. We examined the locomotor activity, and impulsive and social behaviors of AC1+ mice, a
Cao, Hong, Chen, Xuanmao, Saraf, Amit, Storm, Daniel R., Zweifel, Larry S.   +4 more
core   +2 more sources

Bacillus anthracis edema factor substrate specificity: evidence for new modes of action [PDF]

, 2012
Since the isolation of Bacillus anthracis exotoxins in the 1960s, the detrimental activity of edema factor (EF) was considered as adenylyl cyclase activity only.
Agrawal, Altaweel, Basler, Bauche, Bell, Benson, Beste, Bock, Bond, Boyd, Bradley, Brown, Burhenne, Carbonetti, Carbonetti, Carson-Walter, Casteel, Christensen, Christensen, Confer, Copsel, Crawford, Crowe, Cunningham, Dalkas, Defer, Deuquet, Ding, Drum, Duesbery, Feld, Firoved, Friedlander, Fu, Fukuhara, Gaion, Gille, Gordon, Göttle, Hammerschmidt, He, Helfman, Hong, Ivarsson, Jernigan, Johnson, Katayama, Katayama, Kaupp, Kintzer, Klimpel, Laine, Larabee, Larabee, Leppla, Liu, Martin Göttle, McDonough, Milne, Mogridge, Mogridge, Newton, Newton, Newton, Newton, Newton, Oncu, O´Brien, Park, Petosa, Pezard, Postea, Puhar, Roland Seifert, Santelli, Scobie, Scobie, Scorpio, Shapiro, Shen, Shirshev, Soelaiman, Stefan Dove, Sun, Tamayo, Taylor, Taylor, Tesmer, Thomas, Tournier, Vitale, Vitale, Vojtova, Yeager, Zong   +94 more
core   +2 more sources

Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites. [PDF]

PLoS ONE, 2012
The most severe form of human malaria is caused by the parasite Plasmodium falciparum. The second messenger cAMP has been shown to be important for the parasite's ability to infect the host's liver, but its role during parasite growth inside erythrocytes,
Eric Salazar, Erin M Bank, Nicole Ramsey, Kenneth C Hess, Kirk W Deitsch, Lonny R Levin, Jochen Buck   +6 more
doaj   +1 more source

Use of a cAMP BRET Sensor to Characterize a Novel Regulation of cAMP by the Sphingosine 1-Phosphate/G13 Pathway [PDF]

, 2007
Regulation of intracellular cyclic adenosine 3',5'-monophosphate (cAMP) is integral in mediating cell growth, cell differentiation, and immune responses in hematopoietic cells. To facilitate studies of cAMP regulation we developed a BRET (bioluminescence
Collins, Julie, Davis, Richard, DeCamp, Dianne, Fraser, Iain, Hsueh, Robert, Jiang, Lily I., Lin, Keng-Mean, Rebres, Robert A., Roach, Tamara, Ross, Elliott M., Sternweis, Paul C., Taussig, Ronald   +11 more
core   +2 more sources