Results 21 to 30 of about 18,703 (229)

Adenylyl cyclases (ACs) in GtoPdb v.2023.1 [PDF]

, 2023
Adenylyl cyclase, E.C. 4.6.1.1, converts ATP to cyclic AMP and pyrophosphate. Mammalian membrane-delimited adenylyl cyclases (nomenclature as approved by the NC-IUPHAR Subcommittee on Adenylyl cyclases [11]) are typically made up of two clusters of six ...
Watts, Val J., Carmen W. Dessauer, Rennolds Ostrom, Seifert, Roland, Roland Seifert, Val J. Watts, Dessauer, Carmen W., Ostrom, Rennolds   +7 more
core   +1 more source

Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

Frontiers in Physiology, 2022
In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely ...
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +1 more source

Structural basis of adenylyl cyclase 9 activation

Nature Communications, 2022
Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes ...
Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov   +12 more
doaj   +1 more source

Adenylyl cyclase 9 as a molecular scaffold to dissect the mechanisms of membrane adenylyl cyclases. [PDF]

Protein Sci
Abstract Adenylyl cyclases (ACs) convert ATP into the second messenger cAMP, thus directly influencing cellular signaling in response to a wide variety of stimuli. Despite their physiological importance, structural studies of isoform‐specific AC regulation are compounded by difficulties in AC expression and purification.
Kantarci I, Haoriwa H, Korkhov VM.
europepmc   +2 more sources

Compartmentalized cAMP Generation by Engineered Photoactivated Adenylyl Cyclases. [PDF]

Cell Chem Biol, 2019
Because small-molecule activators of adenylyl cyclases (AC) affect ACs cell-wide, it is challenging to explore the signaling consequences of AC activity emanating from specific intracellular compartments.
O'Banion CP, Vickerman BM, Haar L, Lawrence DS.   +3 more
europepmc   +2 more sources

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Nigel J. Pyne, Pyne, Nigel J., Brian Furman, Wee Kiat Ong, Furman, Brian L., Ong, Wee Kiat, Ong, W.K., Furman, Brian   +7 more
core   +4 more sources

IP₃-mediated Ca²⁺ release regulates atrial Ca²⁺ transients and pacemaker function by stimulation of adenylyl cyclases. [PDF]

Am J Physiol Heart Circ Physiol, 2021
Inositol trisphosphate (IP3) is a Ca2+-mobilizing second messenger shown to modulate atrial muscle contraction, and is thought to contribute to atrial fibrillation.
Capel RA, Bose SJ, Collins TP, Rajasundaram S, Ayagama T, Zaccolo M, Burton RB, Terrar DA.   +7 more
europepmc   +2 more sources

The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected].. [PDF]

PLoS ONE, 2013
Adenosine 3', 5'-cyclic monophosphate (cAMP) and guanosine 3', 5'-cyclic monophosphate (cGMP) are well-studied second messengers that transmit extracellular signals into mammalian cells, with conserved functions in various other species such as ...
Ulrike Beckert, Wen Yih Aw, Heike Burhenne, Lisa Försterling, Volkhard Kaever, Lisa Timmons, Roland Seifert   +6 more
doaj   +1 more source

AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca2+ Channels

Function, 2021
To ensure specificity of response, eukaryotic cells often restrict signalling molecules to sub-cellular regions. The Ca2+ nanodomain is a spatially confined signal that arises near open Ca2+ channels.
Pulak Kar, Pradeep Barak, Anna Zerio, Yu-Ping Lin, Amy J Parekh, Val J Watts, Dermot M F Cooper, Manuela Zaccolo, Holger Kramer, Anant B Parekh   +9 more
doaj   +1 more source