Inhibitors of membranous adenylyl cyclases. [PDF]
Trends Pharmacol Sci, 2012 Membranous adenylyl cyclases (mACs) constitute a family of nine isoforms with different expression patterns. Studies with mAC gene knockout mice provide evidence for the notion that AC isoforms play distinct (patho)physiological roles. Consequently, there is substantial interest in the development of isoform-selective mAC inhibitors.
Seifert R +4 more
europepmc +6 more sources
Bicarbonate Stimulated Adenylyl Cyclases [PDF]
IUBMB Life, 2004 AbstractBicarbonate ion is fundamental to the biology of all living organisms. HCO3‐ is vital to such diverse physiological processes as carbon fixation, cellular homeostasis, sperm maturation, and nucleotide synthesis. A defined subset of adenylyl cyclases identified in eukaryotes and prokaryotes are directly activated by HCO3‐.
Cann, M.J.
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Biochemical pharmacology of adenylyl cyclases in cancer. [PDF]
Biochem PharmacolGlobally, despite extensive research and pharmacological advancement, cancer remains one of the most common causes of mortality. Understanding the signaling pathways involved in cancer progression is essential for the discovery of new drug targets. The adenylyl cyclase (AC) superfamily comprises glycoproteins that regulate intracellular signaling and ...
Chandra Jena B +3 more
europepmc +3 more sources
Crosstalk of noradrenergic Ca2+ and cAMP signaling in astrocytes of the murine olfactory bulb [PDF]
Cell Communication and SignalingCyclic adenosine monophosphate (cAMP) and Ca²⁺ are ubiquitous second messengers that regulate gene expression, metabolism, and synaptic plasticity. Here, we identified a complex interplay between Ca²⁺ and cAMP signaling pathways in mouse olfactory bulb ...
Jessica Sauer +7 more
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Acceleration and Light-Induced Changes in Cytosolic cAMP Concentration in Euglena gracilis [PDF]
BiomoleculesThe second messenger cyclic AMP (cAMP) is very likely involved in phototactic as well as gravitactic behavior of the unicellular flagellate Euglena gracilis.
Peter Rolf Richter +8 more
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Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor. [PDF]
PLoS ONE, 2015 Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP. Membranous AC1 (AC1) is involved in processes of memory and learning and in muscle pain.
Carolin Lübker, Roland Seifert
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The Love Story between Orai Calcium Entry Channels and Adenylyl Cyclases Gets even more Complicated [PDF]
Function, 2021 Aldebaran M Hofer
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Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells. [PDF]
J Biol Chem, 2018 Class III adenylyl cyclases generate the ubiquitous second messenger cAMP from ATP often in response to environmental or cellular cues. During evolution, soluble adenylyl cyclase catalytic domains have been repeatedly juxtaposed with signal-input domains
Blain-Hartung M +6 more
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Strategies to safely target widely expressed soluble adenylyl cyclase for contraception
Frontiers in Pharmacology, 2022 In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate ...
Jacob Ferreira +2 more
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Frontiers in Physiology, 2023 Human airway smooth muscle (HASM) is the primary target of ßAR agonists used to control airway hypercontractility in asthma and chronic obstructive pulmonary disease (COPD).
Isabella Cattani-Cavalieri +5 more
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