Results 11 to 20 of about 7,241 (191)

Lack of ANKMY2 suppresses kidney cystogenesis in embryonic- and adult-onset polycystic kidney disease. [PDF]

PLoS Genetics
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive bilateral cyst formation. Multiple cellular pathways including second messenger cAMP signaling are dysregulated in ADPKD, but mechanisms initiating cysts are unknown ...
Sun-Hee Hwang, Kyungsuk Choi, Hemant Badgandi, Kevin A White, Yu Xun, Owen M Woodward, Feng Qian, Saikat Mukhopadhyay   +7 more
doaj   +2 more sources

Biochemical pharmacology of adenylyl cyclases in cancer. [PDF]

Biochem Pharmacol
Globally, despite extensive research and pharmacological advancement, cancer remains one of the most common causes of mortality. Understanding the signaling pathways involved in cancer progression is essential for the discovery of new drug targets. The adenylyl cyclase (AC) superfamily comprises glycoproteins that regulate intracellular signaling and ...
Chandra Jena B, Flaherty DP, O'Brien VP, Watts VJ.   +3 more
europepmc   +3 more sources

Acceleration and Light-Induced Changes in Cytosolic cAMP Concentration in Euglena gracilis [PDF]

Biomolecules
The second messenger cyclic AMP (cAMP) is very likely involved in phototactic as well as gravitactic behavior of the unicellular flagellate Euglena gracilis.
Peter Rolf Richter, Jenny Graf, Ferdinand W. M. Haag, Vanessa Scudlo, Selina Wiesmeth, Jens Hauslage, Martin Richter, David Geißler, Michael Lebert   +8 more
doaj   +2 more sources

Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor. [PDF]

PLoS ONE, 2015
Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP. Membranous AC1 (AC1) is involved in processes of memory and learning and in muscle pain.
Carolin Lübker, Roland Seifert
doaj   +2 more sources

The Love Story between Orai Calcium Entry Channels and Adenylyl Cyclases Gets even more Complicated [PDF]

Function, 2021
Aldebaran M Hofer
doaj   +2 more sources

Strategies to safely target widely expressed soluble adenylyl cyclase for contraception

Frontiers in Pharmacology, 2022
In humans, the prototypical second messenger cyclic AMP is produced by 10 adenylyl cyclase isoforms, which are divided into two classes. Nine isoforms are G protein coupled transmembrane adenylyl cyclases (tmACs; ADCY1-9) and the 10th is the bicarbonate ...
Jacob Ferreira, Lonny R. Levin, Jochen Buck   +2 more
doaj   +1 more source

Quantitative phosphoproteomic analysis reveals unique cAMP signaling pools emanating from AC2 and AC6 in human airway smooth muscle cells

Frontiers in Physiology, 2023
Human airway smooth muscle (HASM) is the primary target of ßAR agonists used to control airway hypercontractility in asthma and chronic obstructive pulmonary disease (COPD).
Isabella Cattani-Cavalieri, Yue Li, Jordyn Margolis, Amy Bogard, Moom R. Roosan, Rennolds S. Ostrom   +5 more
doaj   +1 more source

Assessing potency and binding kinetics of soluble adenylyl cyclase (sAC) inhibitors to maximize therapeutic potential

Frontiers in Physiology, 2022
In mammalian cells, 10 different adenylyl cyclases produce the ubiquitous second messenger, cyclic adenosine monophosphate (cAMP). Amongst these cAMP-generating enzymes, bicarbonate (HCO3−)-regulated soluble adenylyl cyclase (sAC; ADCY10) is uniquely ...
Thomas Rossetti, Jacob Ferreira, Lubna Ghanem, Hannes Buck, Clemens Steegborn, Robert W. Myers, Peter T. Meinke, Lonny R. Levin, Jochen Buck   +8 more
doaj   +1 more source

Structural basis of adenylyl cyclase 9 activation

Nature Communications, 2022
Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes ...
Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov   +12 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source