Results 51 to 60 of about 8,032 (234)

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

An investigation of the response of a model class IIIA Adenyly Cyclase to carbon dioxide [PDF]

, 2009
Adenylyl cyclase catalyses the conversion of adenosine triphosphate into 3’,5'-cyclic adenosine monophosphate and pyrophosphate. Adenylyl cyclases are grouped into six distinct Classes based on amino acid sequence similarity.
Holliday, Phillip
core  

Adenylyl cyclases 1 and 8 initiate a presynaptic homeostatic response to ethanol treatment. [PDF]

PLoS ONE, 2009
BACKGROUND:Although ethanol exerts widespread action in the brain, only recently has progress been made in understanding the specific events occurring at the synapse during ethanol exposure. Mice deficient in the calcium-stimulated adenylyl cyclases, AC1
Alana C Conti, James W Maas, Krista L Moulder, Xiaoping Jiang, Bhumy A Dave, Steven Mennerick, Louis J Muglia   +6 more
doaj   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

THE IDENTIFICATION OF NOVEL INORGANIC CARBON SENSITIVE ENZYMES [PDF]

, 2010
Adenylyl cyclase catalyses the formation of the second messenger adenosine-3’, 5’-monophosphate from adenosine triphosphate, and is involved in a number of diverse signalling pathways in eukaryotes and prokaryotes.
TOWNSEND, PHILIP,DAVID, Townsend, Philip David   +1 more
core  

The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates

BMC Genomics, 2002
Background The CyaB protein from Aeromonas hydrophila has been shown to possess adenylyl cyclase activity. While orthologs of this enzyme have been found in some bacteria and archaea, it shows no detectable relationship to the classical nucleotide ...
Aravind L, Iyer Lakshminarayan M
doaj   +1 more source

Soluble adenylyl cyclase: A novel player in cardiac hypertrophy induced by isoprenaline or pressure overload. [PDF]

PLoS ONE, 2018
In contrast to the membrane bound adenylyl cyclases, the soluble adenylyl cyclase (sAC) is activated by bicarbonate and divalent ions including calcium.
Ilona Schirmer, Tippaporn Bualeong, Heidi Budde, Diana Cimiotti, Avinash Appukuttan, Nicole Klein, Philip Steinwascher, Peter Reusch, Andreas Mügge, Rainer Meyer, Yury Ladilov, Kornelia Jaquet   +11 more
doaj   +1 more source

Class III nucleotide cyclases in bacteria and archaebacteria: lineage-specific expansion of adenylyl cyclases and a dearth of guanylyl cyclases

, 2004
The Class III nucleotide cyclases are found in bacteria, eukaryotes and archaebacteria. Our survey of the bacterial and archaebacterial genome and plasmid sequences identified 193 Class III cyclase genes in only 29 species, of which we predict the ...
Shenoy, Avinash R., Shenoy, Avinash R, Sandhya S. Visweswariah, Visweswariah, Sandhya S., Visweswariah, Sandhya S, Avinash R. Shenoy   +5 more
core   +1 more source

Astrocytic Calcium and cAMP in Neurodegenerative Diseases

Frontiers in Cellular Neuroscience, 2022
It is commonly accepted that the role of astrocytes exceeds far beyond neuronal scaffold and energy supply. Their unique morphological and functional features have recently brough much attention as it became evident that they play a fundamental role in ...
Marta Sobolczyk, Tomasz Boczek
doaj   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source