Results 51 to 60 of about 18,703 (229)
Raf kinase activation of adenylyl cyclases: isoform-selective regulation [PDF]
, 2020 Adenylyl cyclases (AC), a family of enzymes that catalyze the synthesis of cyclic AMP, are critical regulators of cellular functions. The activity of adenylyl cyclase is stimulated by a range of hormone receptors, primarily via interactions with G ...
Robert Gros +5 more
core
, 2020 The poster describes our research to identify cell-permeable small molecule inhibitors of mammalian transmembrane adenylyl cyclases expressed in the fission yeast Schizosaccharomyces pombe.Video walkthrough of poster 581B describing HTSs to identify ...
Sheng Xiang Huang (8708677) +7 more
core +1 more source
Stimulation of Mammalian G-protein-responsive Adenylyl Cyclases by Carbon Dioxide [PDF]
, 2009 Carbon dioxide is fundamental to the physiology of all organisms. There is considerable interest in the precise molecular mechanisms that organisms use to directly sense CO2.
Holliday, PM +6 more
core +1 more source
CellsDictyostelium is a unique model used to study the complex and interactive cyclic nucleotide signaling pathways that regulate multicellular development.
Pundrik Jaiswal, Alan R. Kimmel
doaj +1 more source
The Dictyostelium discoideum acaA gene is transcribed from alternative promoters during aggregation and multicellular development. [PDF]
PLoS ONE, 2010 BACKGROUND: Extracellular cAMP is a key extracellular signaling molecule that regulates aggregation, cell differentiation and morphogenesis during multi-cellular development of the social amoeba Dictyostelium discoideum.
Maria Galardi-Castilla +3 more
doaj +1 more source
A defined subset of adenylyl cyclases is regulated by bicarbonate ion [PDF]
, 2003 The molecular basis by which organisms detect and respond to fluctuations in inorganic carbon is not known. The cyaB1 gene of the cyanobacterium Anabaena sp.
Cann, M.J. +3 more
core +1 more source
Characterization of calcium regulated adenylyl cyclases
, 2018 Adenylyl cyclases are key points for the concurrent integration of diverse signaling pathways. Controlling production of the second messenger cAMP, adenylyl cyclases provide an important mechanism for the regulation of physiological functions by ...
Trevor B. Doyle (5929646) +1 more
core +2 more sources
An investigation of the response of a model class IIIA Adenyly Cyclase to carbon dioxide [PDF]
, 2009 Adenylyl cyclase catalyses the conversion of adenosine triphosphate into 3’,5'-cyclic adenosine monophosphate and pyrophosphate. Adenylyl cyclases are grouped into six distinct Classes based on amino acid sequence similarity.
Holliday, Phillip
core
Advanced Science, EarlyView.ABSTRACT The LRRK2 G2019S mutation, a Parkinson's disease–linked variant, has been associated with depression‐like phenotypes, but mechanisms remain unclear. We chart age‐dependent behavioral changes and astrocyte reactivity in G2019S mice and define a pathway connecting LRRK2 to TFEB/GDNF signaling, cellular energetics, and inflammation.
Longping Yao +5 more
wiley +1 more source
THE IDENTIFICATION OF NOVEL INORGANIC CARBON SENSITIVE ENZYMES [PDF]
, 2010 Adenylyl cyclase catalyses the formation of the second messenger adenosine-3’, 5’-monophosphate from adenosine triphosphate, and is involved in a number of diverse signalling pathways in eukaryotes and prokaryotes.
TOWNSEND, PHILIP,DAVID +1 more
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