Results 51 to 60 of about 19,332 (219)

Functional Crypto-Adenylate Cyclases Operate in Complex Plant Proteins

Frontiers in Plant Science, 2021
Adenylyl cyclases (ACs) and their catalytic product cAMP are regulatory components of many plant responses. Here, we show that an amino acid search motif based on annotated adenylate cyclases (ACs) identifies 12 unique Arabidopsis thaliana candidate ACs,
Inas Al-Younis, Basem Moosa, Mateusz Kwiatkowski, Krzysztof Jaworski, Aloysius Wong, Aloysius Wong, Chris Gehring, Chris Gehring   +7 more
doaj   +1 more source

Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases

Molecular Pain, 2006
Background The Ca2+/calmodulin-stimulated adenylyl cyclase (AC) isoforms AC1 and AC8, couple NMDA receptor activation to cAMP signaling pathways in neurons and are important for development, learning and memory, drug addiction and persistent pain.
Petrovic Michele J, Zastepa Evelyn, Ko Shanelle W, Wang Hansen, Vadakkan Kunjumon I, Sluka Kathleen A, Zhuo Min   +6 more
doaj   +1 more source

Cyclic nucleotide binding and structural changes in the isolated GAF domain of Anabaena adenylyl cyclase, CyaB2 [PDF]

PeerJ, 2015
GAF domains are a large family of regulatory domains, and a subset are found associated with enzymes involved in cyclic nucleotide (cNMP) metabolism such as adenylyl cyclases and phosphodiesterases.
Kabir Hassan Biswas, Suguna Badireddy, Abinaya Rajendran, Ganesh Srinivasan Anand, Sandhya S. Visweswariah   +4 more
doaj   +2 more sources

P-Rex1 Controls Sphingosine 1-Phosphate Receptor Signalling, Morphology, and Cell-Cycle Progression in Neuronal Cells

Cells, 2021
P-Rex1 is a guanine-nucleotide exchange factor (GEF) that activates Rac-type small G proteins in response to the stimulation of a range of receptors, particularly G protein-coupled receptors (GPCRs), to control cytoskeletal dynamics and other Rac ...
Elizabeth Hampson, Elpida Tsonou, Martin J. Baker, David C. Hornigold, Roderick E. Hubbard, Andrew Massey, Heidi C. E. Welch   +6 more
doaj   +1 more source

Adenylyl cyclase alpha and cAMP signaling mediate Plasmodium sporozoite apical regulated exocytosis and hepatocyte infection. [PDF]

PLoS Pathogens, 2008
Malaria starts with the infection of the liver of the host by Plasmodium sporozoites, the parasite form transmitted by infected mosquitoes. Sporozoites migrate through several hepatocytes by breaching their plasma membranes before finally infecting one ...
Takeshi Ono, Laura Cabrita-Santos, Ricardo Leitao, Esther Bettiol, Lisa A Purcell, Olga Diaz-Pulido, Lucy B Andrews, Takushi Tadakuma, Purnima Bhanot, Maria M Mota, Ana Rodriguez   +10 more
doaj   +1 more source

High throughput screening for chemical inhibitors of mammalian adenylyl cyclases expressed in fission yeast

, 2020
The poster describes our research to identify cell-permeable small molecule inhibitors of mammalian transmembrane adenylyl cyclases expressed in the fission yeast Schizosaccharomyces pombe.Video walkthrough of poster 581B describing HTSs to identify ...
Sheng Xiang Huang (8708677), Juliane Dessalines (8708680), James Inglese (5824572), Patricia K. Dranchak (6919664), Jeremy Eberhard (8708679), Nicholas Ollila (8708681), Harrison Silva (8708682), Charles Hoffman (8708674)   +7 more
core   +1 more source

Mycobacterial adenylyl cyclases: Biochemical diversity and structural plasticity [PDF]

, 2006
The conversion of adenine and guanine nucleoside triphosphates to cAMP and cGMP is carried out by nucleotide cyclases, which vary in their primary sequence and are therefore grouped into six classes.
Shenoy, Avinash R., Shenoy, Avinash R, Sandhya S. Visweswariah, Visweswariah, Sandhya S., Visweswariah, Sandhya S, Avinash R. Shenoy   +5 more
core   +1 more source

Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling in Dictyostelium

Cells
Dictyostelium is a unique model used to study the complex and interactive cyclic nucleotide signaling pathways that regulate multicellular development.
Pundrik Jaiswal, Alan R. Kimmel
doaj   +1 more source

Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa. [PDF]

PLoS ONE, 2016
In mammals, adenosine 3', 5'-cyclic monophosphate (cAMP) is known to play highly important roles in sperm motility and acrosomal exocytosis. It is known to act through protein phosphorylation via PRKA and through the activation of guanine nucleotide ...
Serge Goupil, Loïze Maréchal, Hassan El Hajj, Marie-Ève Tremblay, François J Richard, Pierre Leclerc   +5 more
doaj   +1 more source

Class III nucleotide cyclases in bacteria and archaebacteria: lineage-specific expansion of adenylyl cyclases and a dearth of guanylyl cyclases

, 2004
The Class III nucleotide cyclases are found in bacteria, eukaryotes and archaebacteria. Our survey of the bacterial and archaebacterial genome and plasmid sequences identified 193 Class III cyclase genes in only 29 species, of which we predict the ...
Shenoy, Avinash R., Shenoy, Avinash R, Sandhya S. Visweswariah, Visweswariah, Sandhya S., Visweswariah, Sandhya S, Avinash R. Shenoy   +5 more
core   +1 more source