Results 141 to 150 of about 83,442 (296)
G protein-coupled receptors (GPCR) linked to stimulatory G (Gs) proteins (GsPCR) mediate increases in intracellular cyclic AMP as consequence of activation of nine adenylyl cyclases (AC), which differ considerably in their cellular distribution and ...
Rosely Oliveira Godinho+2 more
doaj +1 more source
Eukaryotic-like Adenylyl Cyclases in Mycobacterium tuberculosis H37Rv
Screening the Mycobacterium tuberculosis H37Rv genomic library for complementation of catabolic defect for cAMP-dependent expression of maltose operon produced the adenylyl cyclase gene (Mtb cya,GenBankTM accession no. AF017731 (1997)) annotated later as
Sathyavelu K. Reddy+5 more
semanticscholar +1 more source
Abstract Background and Purpose Several G protein‐coupled receptors (GPCRs) are known to homodimerise. Dimeric GPCRs may have different properties from their monomers, but the molecular basis and functional significance of GPCR dimerisation remain largely unknown.
Satoshi Asano+6 more
wiley +1 more source
Blue LED irradiation targeted metabolic coupling between CAFs and colon cancer cells. Abstract Background The concepts examined in tumor metabolism research have been moving away from cancer cells themselves and the tumor microenvironment has become a focus of investigation.
Masaaki Nishi+8 more
wiley +1 more source
Adenylyl cyclases (ACs) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database [PDF]
Adenylyl cyclase, E.C. 4.6.1.1, converts ATP to cyclic AMP and pyrophosphate. Mammalian membrane-delimited adenylyl cyclases (nomenclature as approved by the NC-IUPHAR Subcommittee on Adenylyl cyclases [9]) are typically made up of two clusters of six TM
Dessauer, Carmen W.+3 more
core +2 more sources
TET family proteins play a critical role in DNA demethylation, and their mutations and dysregulation contribute to the onset of multiple diseases. With a deeper understanding of the molecular mechanisms of TET involvement in disease, drug therapy targeting TET proteins shows great potential, which provides insights into new therapeutic strategies ...
Junzhi Liang+12 more
wiley +1 more source
Characterization of the Blue-Light-Activated Adenylyl Cyclase mPAC by Flash Photolysis and FTIR Spectroscopy [PDF]
The recently discovered photo-activated adenylyl cyclase (mPAC from Microcoleus chthonoplastes) is the first PAC that owes a light-, oxygen- and voltage-sensitive (LOV) domain for blue-light sensing.
Alexandre+41 more
core +1 more source
Cyclic AMP (cAMP) is a ubiquitous secondary signaling molecule, commonly associated with many bacterial processes, including the regulation of virulence factors, such as biofilms, pellicles and motility (Wolfgang, 2003). The quantity of available cAMP is
Sarah Giles, Uwe Stroeher, Melissa Brown
doaj +1 more source
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni+5 more
wiley +1 more source
OBJECTIVES/SPECIFIC AIMS: Our objective is to study the role of soluble adenylyl cyclase in the melanocyte regulation of pigment in response to ultraviolet radiation. Melanocytes are specialized cells that produce melanin in organelles called melanosomes,
Koji Ota, Dalee Zhou, Jonathan Zippin
doaj +1 more source