Molecular Pain, 2006 Background The Ca2+/calmodulin-stimulated adenylyl cyclase (AC) isoforms AC1 and AC8, couple NMDA receptor activation to cAMP signaling pathways in neurons and are important for development, learning and memory, drug addiction and persistent pain.
Petrovic Michele J +6 more
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A role for calmodulin-stimulated adenylyl cyclases in cocaine sensitization. [PDF]
J Neurosci, 2009 Cocaine sensitization is produced by repeated exposure to the drug and is thought to reflect neuroadaptations that contribute to addiction. Here, we identify the Ca2+/calmodulin-stimulated adenylyl cyclases, type 1 (AC1) and type 8 (AC8), as novel ...
DiRocco DP +4 more
europepmc +2 more sources
cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes. [PDF]
Mol Pharmacol, 2018 Johnstone TB +3 more
europepmc +2 more sources
Regulation of prokaryotic adenylyl cyclases by CO2. [PDF]
Biochemical Journal, 2006 The Slr1991 adenylyl cyclase of the model prokaroyte Synechocystis PCC 6803 was stimulated 2-fold at 20 mM total C(i) (inorganic carbon) at pH 7.5 through an increase in k(cat).
A. Hammer, David R. W. Hodgson, M. Cann
semanticscholar +6 more sources
Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor. [PDF]
PLoS ONE, 2015 Adenylyl cyclases (ACs) catalyze the conversion of ATP into the second messenger cAMP. Membranous AC1 (AC1) is involved in processes of memory and learning and in muscle pain.
Carolin Lübker, Roland Seifert
doaj +2 more sources
International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. [PDF]
Pharmacol Rev, 2017 Dessauer CW +5 more
europepmc +2 more sources
Regulation of Adenylyl Cyclase by Membrane Potential [PDF]
Journal of Biological Chemistry, 1998 Mammalian adenylyl cyclases possess 12 transmembrane-spanning domains and bear a superficial resemblance to certain classes of ion channels. Some evidence suggests that bacterial and sea urchin sperm adenylyl cyclases can be regulated by membrane depolarization. In the present study, we explored the effect of altering membrane potential on the adenylyl
Dermot M.F. Cooper +3 more
openalex +6 more sources
Pharmacological distinction between soluble and transmembrane adenylyl cyclases. [PDF]
J Pharmacol Exp Ther, 2013 Bitterman JL +4 more
europepmc +2 more sources
Adenylyl cyclases types 1 and 8 promote pro-survival pathways after ethanol exposure in the neonatal brain [PDF]
Neurobiology of Disease, 2009 Although a wide range of developmental disabilities following fetal alcohol exposure are observed clinically, the molecular factors that determine the severity of these sequelae remain undefined. In mice exposed to ethanol, deletion of adenylyl cyclases (
Alana C. Conti +3 more
doaj +3 more sources
Stimulation of renin secretion by catecholamines is dependent on adenylyl cyclases 5 and 6. [PDF]
Hypertension, 2011 Aldehni F +8 more
europepmc +2 more sources