Results 151 to 160 of about 53,252 (254)

Aberrant Molecular Myelin Architecture in Charcot–Marie–Tooth Disease Type 1A and Hereditary Neuropathy With Liability to Pressure Palsies

Glia, Volume 74, Issue 2, February 2026.
PMP22 copy number variation disrupts myelin architecture at SLIs and Nodes of Ranvier. Adherens junction and axoglial domain defects are often more severe in CMT1A than HNPP. Findings support PMP22 functioning as a structural organizer of myelin. ABSTRACT Charcot–Marie–Tooth Disease Type 1A (CMT1A) and Hereditary Neuropathy with Liability to Pressure ...
Kathryn R. Moss, Marvis A. Arowolo, Dave R. Gutierrez, Ahmet Höke   +3 more
wiley   +1 more source

Northwestern European Ancestry Predominates in Idiopathic Subglottic Stenosis: Results From an English‐Speaking Cohort

Laryngoscope Investigative Otolaryngology, Volume 11, Issue 1, February 2026.
ABSTRACT Objective To investigate the ancestral background of patients with idiopathic subglottic stenosis (iSGS) using genetic testing results. Methods A de‐identified survey collecting genetic testing service ancestry data results, in addition to self‐reported ancestry, personal autoimmune history, and any family history of iSGS, was distributed to ...
Jarod Karom, Molly O. Hunter, Catherine Anderson, Zachary Thomas Root, Laura A. Matrka   +4 more
wiley   +1 more source

Lateral adherens junctions mediate a supracellular actomyosin cortex in drosophila trachea. [PDF]

iScience, 2023
Pradhan R, Kumar S, Mathew R.
europepmc   +1 more source

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

Distinct Roles of IL‐4, IL‐13, and IL‐22 in Human Skin Barrier Dysfunction and Atopic Dermatitis

Allergy, Volume 81, Issue 2, Page 480-497, February 2026.
This study reports the distinct effects of IL‐4, IL‐13, and IL‐22 on bio‐stabilized human skin with intact barriers and immune cells. IL‐4, IL‐13, and IL‐22 upregulate inflammatory mediators, disrupt skin barrier integrity, and reciprocally modulate IL‐4Rα and IL‐22Rα1 receptors.
Paolo D'Avino, Juno Kim, Manru Li, Philipp Gessner, Patrick Westermann, Yagız Pat, Carina Beha, Claudia Traidl‐Hoffmann, Jeremy Bost, Nicolas Gaudenzio, Christoph B. Messner, Cezmi A. Akdis, Yasutaka Mitamura   +12 more
wiley   +1 more source

THY1 (CD90) Maintains the Adherens Junctions in Nasopharyngeal Carcinoma via Inhibition of SRC Activation. [PDF]

Cancers (Basel), 2023
Chen L, Chau WY, Yuen HT, Liu XH, Qi RZ, Lung ML, Lung HL.   +6 more
europepmc   +1 more source

Alterations in Gut Microbiota and Metabolism in Cirrhotic Portal Hypertension: Implications for Disease Progression

Alimentary Pharmacology &Therapeutics, Volume 63, Issue 4, Page 538-556, February 2026.
In‐depth multiomics analyses revealed that the gut microbiota in patients with CPH is dysbiotic. Altered gut microbiota plays an important role in the progression of CPH and affects the host's arginine metabolism to promote arginine biosynthesis. The pro‐inflammatory effects of certain gut bacteria induce iNOS expression, which together act on the ...
Qun Zhang, Jinghua Cui, Yixin Hou, Lining Guo, Hai Li, Guiqin Zhou, Xiaojing Wang, Bingbing Zhu, Ke Shi, Yi Zhang, Yufei Bi, Yanqiu Li, Lina Sun, Ying Feng, Jing Yuan, Xianbo Wang   +15 more
wiley   +1 more source

The tandem–random transition of cellular patterning: proposed roles of N‐cadherin‐based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus

Biological Reviews, Volume 101, Issue 1, Page 268-278, February 2026.
ABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Xiangyun Wei, Nam Vo, Gwendolyn A. Sowa
wiley   +1 more source

Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions. [PDF]

Nat Commun, 2023
Tiruppathi C, Wang DM, Ansari MO, Bano S, Tsukasaki Y, Mukhopadhyay A, Joshi JC, Loch C, Niessen HWM, Malik AB.   +9 more
europepmc   +1 more source

Galactomyces ferment filtrate upregulates anchoring junctions and stabilizes actin to maintain the Young's modulus of skin cells in vitro

International Journal of Cosmetic Science, Volume 48, Issue 1, Page 16-29, February 2026.
Ageing causes actin cytoskeleton disorganization, a reduction in cellular components associated with the actin cytoskeleton and focal adhesions, and a reduction in skin firmness. Galactomyces ferment filtrate boosts actin stability, increases expression of anchoring junction proteins, including focal adhesions and protects against loss of firmness ...
Steph Crabtree, Bradley B. Jarrold, Olivia Kent, Matthew C. Ehrman, Timothy J. Hawkins, Viktor Korolchuk, Camila Pereira Braga, John M. Snowball, Makio Tamura, Tomohiro Hakozaki, Akira Matsubara, John E. Oblong, Max Brown   +12 more
wiley   +1 more source