Results 11 to 20 of about 171,177 (219)
Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome.
Journal of Clinical Investigation, 2019 Over the past decade, great progress has been made in understanding the complexity of adipose tissue biology and its role in metabolism. This includes new insights into the multiple layers of adipose tissue heterogeneity, not only differences between ...
C. Kahn +3 more
semanticscholar +1 more source
Role of adipocyte-derived lipoprotein lipase in adipocyte hypertrophy [PDF]
Nutrition & Metabolism, 2007 A major portion of available fatty acids for adipocyte uptake is derived from lipoprotein lipase (LPL)-mediated hydrolysis of circulating lipoprotein particles. In vivo studies aimed at identifying the precise role of adipocyte-derived LPL in fat storage function of adipose tissue have been unable to provide conclusive evidence due to compensatory ...
Amanda M Gonzales, Robert A. Orlando
openaire +4 more sources
Nature Communications, 2019 During wound healing in adult mouse skin, hair follicles and then adipocytes regenerate. Adipocytes regenerate from myofibroblasts, a specialized contractile wound fibroblast. Here we study wound fibroblast diversity using single-cell RNA-sequencing.
C. Guerrero-Juarez +14 more
semanticscholar +1 more source
Single Acquisition Label-free Histology-like Imaging with Dual Contrast Photoacoustic Remote Sensing Microscopy [PDF]
, 2021 Significance: Histopathological analysis of tissues is an essential tool for grading, staging, diagnosing and resecting cancers and other malignancies. Current histopathological techniques require substantial sample processing prior to staining with hematoxylin and eosin (H&E) dyes, to highlight nuclear and cellular morphology.
arxiv +1 more source
Journal of Clinical Investigation, 2019 Persistent, unresolved inflammation in adipose tissue is a major contributor to obesity-associated metabolic complications. However, the molecular links between lipid-overloaded adipocytes and inflammatory immune cells in obese adipose tissues remain ...
Yong Pan +8 more
semanticscholar +1 more source
European Journal of Cell Biology, 2013 Adipocytes are the main constituent of adipose tissue and are considered to be a corner stone in the homeostatic control of whole body metabolism. Their primary function is to control energy balance by storing triacylglycerol in periods of energy excess and mobilizing it during energy deprivation.
Aus Tariq Ali +4 more
openaire +3 more sources
Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics.
Biochemical Journal, 2020 Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD) organelles by professional storage cells called adipocytes.
Alexander Yang, E. Mottillo
semanticscholar +1 more source
Weighing in on Adipocyte Precursors [PDF]
Cell Metabolism, 2014 Obesity, defined as an excessive increase in white adipose tissue (WAT), is a global health epidemic. In obesity, WAT expands by increased adipocyte size (hypertrophy) and number (hyperplasia). The location and cellular mechanisms of WAT expansion greatly affect the pathogenesis of obesity.
Ryan Berry +2 more
openaire +3 more sources
Theoretical Model and Characteristics of Mitochondrial Thermogenesis [PDF]
Biophysics Reports 2018, 2017 Mitochondria of brown adipocyte (BA) are the main intracellular sites for thermogenesis, which have been targeted for therapy to reduce obesity. However, there are long-standing critique and debates about the ability of raising cellular temperature by endogenous thermogenesis.
arxiv +1 more source
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.
New England Journal of Medicine, 2015 BACKGROUND Genomewide association studies can be used to identify disease-relevant genomic regions, but interpretation of the data is challenging. The FTO region harbors the strongest genetic association with obesity, yet the mechanistic basis of this ...
M. Claussnitzer +18 more
semanticscholar +1 more source