Results 41 to 50 of about 171,177 (219)
The metabolic origins of big size in aquatic mammals [PDF]
arXiv, 2022 The group of large aquatic mammals has representatives being the largest living beings on earth, surpassing the weight and size of dinosaurs. In this paper, we present some empirical evidence and a mathematical model to argue that fat accumulation in marine mammals triggers a series of metabolic events that result in these animals' increased size.
arxiv
CIRCADIAN RHYTHMICITY IN MURINE PRE-ADIPOCYTE AND ADIPOCYTE CELLS
Chronobiology International, 2009 Adipose tissue is central to metabolic homeostasis, signaling in part through the secretion of molecules termed adipokines. Circadian rhythms play an important role in adipose physiology, with plasma adipokine concentration and approximately 20 % of the murine adipose transcriptome undergoing 24 h variation. However, due to the heterogeneity of adipose
Otway, DT, Frost, G, Johnston, JD
openaire +6 more sources
Energy landscape reveals the underlying mechanism of cancer-adipose conversion with gene network models [PDF]
arXiv, 2023 Cancer is a systemic heterogeneous disease involving complex molecular networks. Tumor formation involves epithelial-mesenchymal transition (EMT), which promotes both metastasis and plasticity of cancer cells. Recent experiments proposed that cancer cells can be transformed into adipocytes with combination drugs.
arxiv
Scientific Reports, 2018 Obesity is associated with a disturbed adipose tissue (AT) function characterized by adipocyte hypertrophy, an impaired lipolysis and pro-inflammatory phenotype, which contributes to insulin resistance (IR).
K. Verboven +11 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Single-cell sequencing technologies are providing unexpected insights on how seemingly homogenous cell populations differ markedly in their functional properties, and how diverse cell repertoires mediate the functions of tissues and organs ...
S. Min +12 more
semanticscholar +1 more source
Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity
Nature Metabolism, 2019 Depleting creatine levels in thermogenic adipocytes by inhibiting creatine biosynthesis reduces thermogenesis and causes obesity. However, whether creatine import from the circulation affects adipocyte thermogenesis is unknown. Here we show that deletion
L. Kazak +15 more
semanticscholar +1 more source
Contrôle paracrine du développement du tissu adipeux par l'autotaxine et l'acide lysophosphatidique [PDF]
arXiv, 2006 Secretion and role of autotaxin and lysophosphatidic acid in adipose tissue In obesity, adipocyte hypertrophy is often associated with recrutement of new fat cells (adipogenesis) under the control of circulating and local regulatory factors. Among the different lipids released in the extracellular compartment of adipocytes, our group found the presence
arxiv
Journal of experimental & clinical cancer research : CR, 2019 Emerging evidence supports the pivotal roles of adipocytes in breast cancer progression. Tumour induced beige/brown adipose tissue differentiation contributes to the hypermetabolic state of the breast cancer.
Qi Wu +10 more
semanticscholar +1 more source
Laser induced topological cues shape, guide, and anchor human Mesenchymal Stem Cells [PDF]
arXiv, 2018 This report focuses on the effect of the surface topography of the substrate on the behavior of human mesenchymal stem cells from bone marrow (MSCs) before and after co-differentiation into adipocytes and osteoblasts. Picosecond pulsed laser ablation technology was applied to generate different microstructures (microgrooves and microcavities) on poly ...
arxiv
Adipocyte, 2019 Macroscopic deposition of epicardial adipose tissue (EAT) has been strongly associated with numerous indices of obesity and cardiovascular disease risk. In contrast, the morphology of EAT adipocytes has rarely been investigated.
Hamish M. Aitken-Buck +14 more
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