Results 231 to 240 of about 946,668 (293)

Cinnamic Acid Attenuates Ethanol‐Exacerbated Hepatocyte Pyroptosis in Type 2 Diabetes via AMPK‐Mediated NLRP3/GSDMD Inhibition

Phytotherapy Research, EarlyView.
CA directly binds to and activates AMPK to suppress NLRP3/GSDMD signaling, thereby alleviating hepatocyte pyroptosis in T2DM mice. ABSTRACT Type 2 diabetes mellitus (T2DM) is frequently accompanied by chronic ethanol (ET) consumption, which worsens metabolic dysregulation and organ damage.
Huaiying Tang, Qin Xiang, Yue Zhang, Yu Zhang, Xiangxiang Fu, Liming Tan, Yongli Zhang, Siqi Li, Dong Gong, Xu Guo, Yonghong Zhang, Li Chen, Tao Zheng, Qibin Wang   +13 more
wiley   +1 more source

Novel function of TREK-1 in regulating adipocyte differentiation and lipid accumulation. [PDF]

Cell Death Dis
Kim A, Jung S, Kim Y, Jung J, Lee S, Lee H, Kim MJ, Park JY, Hwang EM, Lee J.   +9 more
europepmc   +1 more source

Mogroside V Promotes Brown Adipose Thermogenesis via FTO‐m6A‐LETMD1‐UCP1 Pathway to Combat Obesity

Phytotherapy Research, EarlyView.
Mogroside V (MV) alleviates high‐fat diet‐induced obesity and metabolic dysfunction. Mechanistically, MV suppresses FTO expression, thereby increasing m6A modification of Letmd1 mRNA and enhancing its YTHDC2‐dependent stabilization. Theincreased LETMD1 expression is associated with elevated PGC1α and UCP1 levels, contributing to brown adipocyte ...
Yuan‐hai Sun, Ling‐huan Li, Ya‐qian Feng, Teng‐jiao Zhao, Min‐you Qi, Han‐bing Li   +5 more
wiley   +1 more source

Cross-talks between Metabolic and Translational Controls during Beige Adipocyte Differentiation. [PDF]

Nat Commun
Youn D, Kim B, Jeong D, Lee JY, Kim S, Sumberzul D, Ginting RP, Lee MW, Song JH, Park YS, Kim Y, Oh CM, Lee M, Cho J.   +13 more
europepmc   +1 more source

Magnoflorine Ameliorates MASH in Mice Fed a High‐Fat and High‐Fructose Diet by Promoting AMPK‐Mediated Lipophagy and Fatty Acid Oxidation

Phytotherapy Research, EarlyView.
Magnoflorine ameliorates metabolic dysfunction‐associated steatohepatitis by promoting AMPKα‐mediated lipophagy and fatty acid oxidation. ABSTRACT Emerging as a significant clinical burden, metabolic dysfunction‐associated steatohepatitis (MASH) continues to challenge global healthcare systems due to limited effective interventions.
Zhengjie Lu, Tongyun Mao, Longxin Chai, Kaiqi Chen, Kexin Liu, Cong Zhang, Hao Kou   +6 more
wiley   +1 more source

HIV infection drives proinflammatory adipocyte differentiation in an <i>in vitro</i> model and reveals a new inflammatory pathway. [PDF]

Front Cell Infect Microbiol
Freiberger RN, López CAM, Sviercz FA, Jarmoluk P, Palma MB, García MN, Quarleri J, Delpino MV.   +7 more
europepmc   +1 more source

Microplastics and the Endocrine–Metabolic Interface: Novel Diagnostic Tools Targeting Thyroid–Adipose Axis

Environmental Toxicology, EarlyView.
ABSTRACT Microplastics (MPs) have been identified as major environmental contaminants that can affect organisms directly and act as carriers of particles and chemical additives, thereby aggravating endocrine networks that coordinate metabolic homeostasis.
Sunday Amos Onikanni, Babasola Aiyeku, Marjorie Dardis Murucci, Temitope Aribigbola, Kenia Bispo, Oluwatosin Stella Olayinka, Rômulo Sperduto Dezonne, Sara Gemini Piperni, Paula Soares, Denise Pires de Carvalho, Leandro Miranda‐Alves   +10 more
wiley   +1 more source

Correction to "Sweet Science: Exploring the Impact of Fructose and Glucose on Brown Adipocyte Differentiation Using Optical Diffraction Tomography". [PDF]

J Cell Biochem
europepmc   +1 more source

LincRNA-MSTRG.673.2 Promotes Chicken Intramuscular Adipocyte Differentiation by Sponging miR-128-3p. [PDF]

Animals (Basel)
Zhang B, Zhu S, He Y, Liang W, Zhu T, Han R, Li D, Wang Y, Tian Y, Li G, Kang X, Li W, Sun G.   +12 more
europepmc   +1 more source