Results 241 to 250 of about 118,942 (299)

A key role for P2RX5 in brown adipocyte differentiation and energy homeostasis. [PDF]

Adipocyte
Razzoli M, McGonigle S, Sahu BS, Rodriguez P, Svedberg D, Rao L, Ruocco C, Nisoli E, Vezzani B, Frontini A, Bartolomucci A.   +10 more
europepmc   +1 more source

The potential for biased signalling in the P2Y receptor family of GPCRs

British Journal of Pharmacology, EarlyView.
The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk, Simon Pitchford, Graham Ladds   +2 more
wiley   +1 more source

YAP and ECM Stiffness: Key Drivers of Adipocyte Differentiation and Lipid Accumulation. [PDF]

Cells
Dong DL, Jin GZ.
europepmc   +1 more source

PDE4D and PDE3B orchestrate distinct cAMP microdomains in 3T3‐L1 adipocytes

British Journal of Pharmacology, EarlyView.
Basal conditions: •Ins/PDE3B lowers cytoplasmic cAMP (cyt‐cAMP) without affecting plasma membrane cAMP (pm‐cAMP). •Insulin decreases lipid droplet cAMP (LD‐cAMP) independent of PDE3B. •FGF1/PDE4D modestly reduces both cyt‐ and pm‐cAMP, while PDE4D alone can modulate LD‐cAMP. ISO stimulation: •Ins/PDE3B has minimal impact on cyt‐cAMP.
Johannes Krier, David Spähn, David Arturo Juarez Lopez, Judith L. Nono, Judith Seigner, Lisa Jacob, Siegfried Ussar, Robert Lukowski, Andreas L. Birkenfeld, Gencer Sancar   +9 more
wiley   +1 more source

Neddylation and Its Target Cullin 3 Are Essential for Adipocyte Differentiation. [PDF]

Cells
Zhou H, Patel V, Rice R, Lee R, Kim HW, Weintraub NL, Su H, Chen W.   +7 more
europepmc   +1 more source

Neurokinin‐1 receptor activation protects against cardiac fibrosis, inflammation and diastolic dysfunction in type 2 diabetic mice

British Journal of Pharmacology, EarlyView.
Background and Purpose The pathogenesis of type 2 diabetes mellitus (T2DM)‐induced cardiomyopathy involves cardiac fibrosis that leads to diastolic dysfunction. We established that replacement of lost substance P (SP) that occurs in T2DM reduces cardiac fibrosis and decreases inflammation in T2DM mice and non‐human primates.
Alexander Widiapradja, Heather Connery, Brody J. Helmick, Kallie J. Schafner, Vamsi Manchikalapudi, Hannah Horvath, Sophia Gugino, Tamas Kriska, Anja Herrnreiter, Evan DeVallance, William B. Campbell, Scott P. Levick   +11 more
wiley   +1 more source

Circ_0011446 Regulates Intramuscular Adipocyte Differentiation in Goats via the miR-27a-5p/FAM49B Axis. [PDF]

Int J Mol Sci
Wang JM, Lv JS, Liu KH, Li YY, Zhu JJ, Xiong Y, Wang Y, Lin YQ.   +7 more
europepmc   +1 more source

Investigating the crosstalk between ABCC4 and ABCC5 in 3T3-L1 adipocyte differentiation. [PDF]

Front Mol Biosci
Laddha AP, Wahane A, Bahal R, Manautou JE.   +3 more
europepmc   +1 more source

Hypoxia Regulates Brown Adipocyte Differentiation and Stimulates miR-210 by HIF-1α. [PDF]

Int J Mol Sci
Caca J, Bartelt A, Egea V.
europepmc   +1 more source