Results 61 to 70 of about 946,668 (293)
Advanced Science, EarlyView.Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen +20 more
wiley +1 more source
Frontiers in Cell and Developmental Biology, 2022 Substantial levels of lysozyme in adipose tissue in association to obesity have been recently demonstrated in mice and humans. In addition, experiments in mice suggest that lysozyme might impact on adipose tissue adipogenesis.
Aina Lluch +7 more
doaj +1 more source
An investigation of the early molecular regulation of adipogenesis in human mesenchymal stem cells. [PDF]
, 2006 Human bone marrow-derived mesenchymal stem cells (hMSCs) can differentiate in vitro into various lineages including adipocytes, osteoblasts, and chondrocytes.
Westwood, Claire, Westwood, C.
core
Adipocyte differentiation and cellularity.
, 2015 Abbreviation used: LD, longissimus dorsi muscle; PRAT, perirenal fat; SCAT dorsal subcutaneous adipose tissue.aPigs (42 d of age) were fed either a methionine-deficient (MD) diet or a control (CTRL) diet providing an adequate level of methionine for 10 ...
Rosa Castellano (768080) +7 more
core +1 more source
Advanced Science, EarlyView.The adipocyte MKK3–p38β axis emerges as an adaptive stress‐response pathway during obesity. Human visceral adipose tissue analyses, adipocyte‐specific mouse models, and primary adipocytes show that the MKK3–p38β axis supports insulin responsiveness by restraining p70S6K‐dependent inhibitory IRS1 feedback and preserving AKT–GLUT4 signaling. This pathway
Edgar Bernardo +20 more
wiley +1 more source
Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Role of RAC3 coactivator in the adipocyte differentiation [PDF]
Cell Death Discovery, 2018 Abstract RAC3 is a member of the p160 family of steroid receptor coactivators and it is highly expressed in several human cancers, contributing to enhanced cell proliferation and cellular transformation. In this work, we have studied the role of RAC3 in adipogenesis in L-929 cells. Adipogenesis is a highly regulated process, involving
María Cecilia Lira +4 more
openaire +3 more sources
G0/G1 switch gene 2 has a critical role in adipocyte differentiation
, 2014 Mouse 3T3-L1 preadipocytes differentiate into adipocytes when treated with 3-isobutyl-1-methylxanthine, dexamethasone, and insulin. Although mechanisms of adipogenesis, including transcriptional cascades, are understood, it is still unclear how clonally ...
김태현 +6 more
core +1 more source
Advanced Science, EarlyView.Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi +7 more
wiley +1 more source
Frontiers in EndocrinologyWhite adipose tissue (WAT) expands through adipocyte hypertrophy or hyperplasia-associated differentiation of progenitor adipose stem cells (ASC). The triggering receptor expressed on myeloid cells 2 (TREM2) reportedly promotes adipocyte differentiation ...
Anja Dobrijevic +17 more
doaj +1 more source