Results 71 to 80 of about 118,942 (299)

Nanothermometry in Living Cells: Physical Limits, Conceptual and Material Challenges

Advanced Functional Materials, EarlyView.
Heat and temperature are fundamental to life. When nanothermometers began probing regions as small as a living cell, they triggered controversial claims of large intracellular temperature gradients. We review physical constraints energy‐conservation, entropy production, thermodynamic fluctuations, and molecular dynamics.
Taras Plakhotnik
wiley   +1 more source

Xanthohumol decreases adipocyte differentiation

The FASEB Journal, 2009
Lately, some phytochemicals have been demonstrated to possess anti‐obesity properties. In this regard we investigated the effect of xanthohumol (XN), a flavonoid from hops ( Humulus lupulus L.) in preadipocyte differentiation.
Diana Teixeira, Vanda Mendes, Diogo Pestana, Conceição Calhau, Isabel Azevedo, Rosário Monteiro   +5 more
openaire   +1 more source

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis [PDF]

, 2010
Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease ...
Bellantuono, I., Coulton, L., Croucher, P.I., Gambardella, A., Hughes, D., Kottam, L., Mohanty, S.T., Nicklin, M.J., Wilson, A.G.   +8 more
core   +3 more sources

Calreticulin inhibits commitment to adipocyte differentiation [PDF]

Journal of Cell Biology, 2015
Calreticulin, an endoplasmic reticulum (ER) resident protein, affects many critical cellular functions, including protein folding and calcium homeostasis. Using embryonic stem cells and 3T3-L1 preadipocytes, we show that calreticulin modulates adipogenesis.
Szabo, Eva, Qiu, Yuanyuan, Baksh, Shairaz, Michalak, Marek, Opas, Michal   +4 more
openaire   +2 more sources

Microengineered Gradient Hydrogels for Mechanobiology

Advanced Healthcare Materials, EarlyView.
Gradient hydrogels are used to mimic the mechanical heterogeneity in native tissues, offering powerful in vitro platforms to study cell‐material interactions in diverse pathophysiological contexts. Here, we present a comprehensive review of the design and experimental considerations for stiffness gradient hydrogels, discussing exemplary achievements ...
Shin Wei Chong, Deepu Ashok, Anna Waterhouse, Marcela M. M. Bilek, Daniele Vigolo   +4 more
wiley   +1 more source

TREM2 promotes adipogenesis of PDGFR-α+ adipose stem cells but is dispensable for adipose remodeling and metabolic health during diet-induced obesity

Frontiers in Endocrinology
White adipose tissue (WAT) expands through adipocyte hypertrophy or hyperplasia-associated differentiation of progenitor adipose stem cells (ASC). The triggering receptor expressed on myeloid cells 2 (TREM2) reportedly promotes adipocyte differentiation ...
Anja Dobrijevic, Anja Dobrijevic, Ana Korosec, Ana Korosec, Julia Stefanie Brunner, Lenka Matejovicova, Lenka Matejovicova, Anna Gemza, Anna Gemza, Karin Lakovits, Hon Shing Lam, Hon Shing Lam, Aloña Agirre-Lizaso, Aloña Agirre-Lizaso, Gernot Schabbauer, Sylvia Knapp, Omar Sharif, Omar Sharif   +17 more
doaj   +1 more source

Pmch-deficiency in rats is associated with normal adipocyte differentiation and lower sympathetic adipose drive. [PDF]

PLoS ONE, 2013
The orexigenic neuropeptide melanin-concentrating hormone (MCH), a product of Pmch, is an important mediator of energy homeostasis. Pmch-deficient rodents are lean and smaller, characterized by lower food intake, body-, and fat mass. Pmch is expressed in
Joram D Mul, Eoghan O'Duibhir, Yogendra B Shrestha, Arjen Koppen, Peter Vargoviç, Pim W Toonen, Eleen Zarebidaki, Richard Kvetnansky, Eric Kalkhoven, Edwin Cuppen, Timothy J Bartness   +10 more
doaj   +1 more source

Wnt4 and Wnt5a promote adipocyte differentiation

FEBS Letters, 2008
The roles of the non‐canonical Wnt pathway during adipogenesis are not well known, though Wnt10b is known to function as a negative regulator for adipogenesis by activating the canonical Wnt pathway. We focused on the roles of Wnt4, Wnt5a and Wnt6, which are thought to be part of the non‐canonical Wnt pathway.
Nishizuka, Makoto, Koyanagi, Akiko, Osada, Shigehiro, Imagawa, Masayoshi   +3 more
openaire   +2 more sources

Blockade of adipocyte differentiation by cordycepin [PDF]

British Journal of Pharmacology, 2012
BACKGROUND AND PURPOSE Cordyceps militaris has the potential to suppress differentiation of pre‐adipocytes. However, the active entities in the extract and the underlying mechanisms of its action are not known. Hence, we investigated whether and how cordycepin (3′‐deoxyadenosine), a constituent of C.
Shuhei, Takahashi, Minori, Tamai, Shotaro, Nakajima, Hironori, Kato, Hisashi, Johno, Tomoyuki, Nakamura, Masanori, Kitamura   +6 more
openaire   +2 more sources