Results 41 to 50 of about 62,511 (120)

The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes

Journal of Lipid Research, 2012
White and brown adipocytes are believed to occupy different sites in the body. We studied the anatomical features and quantitative histology of the fat depots in obesity and type 2 diabetes-prone C57BL/6J mice acclimated to warm or cold temperatures ...
A. Vitali, I. Murano, M.C. Zingaretti, A. Frontini, D. Ricquier, S. Cinti   +5 more
doaj   +1 more source

On the role of macrophages in the control of adipocyte energy metabolism

Endocrine Connections, 2019
The crosstalk between macrophages (MΦ) and adipocytes within white adipose tissue (WAT) influences obesity-associated insulin resistance and other associated metabolic disorders, such as atherosclerosis, hypertension and type 2 diabetes.
Michaela Keuper
doaj   +1 more source

Creatine kinase B mediates UCP1-independent beige fat thermogenesis via the futile creatine cycle in mice

Molecular Metabolism
Objectives: Creatine kinase B (CKB) is the main isoenzyme driving creatine kinase (CK) activity in classical brown adipocytes. However, the specific CK isoenzyme active in beige adipocytes remains unknown.
Jakub Bunk, Mina Ersin, Mohammed F. Hussain, Bozena Samborska, Maria Guerra-Martinez, Drishti Soni, Lawrence Kazak   +6 more
doaj   +1 more source

The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression

Cells, 2019
Obesity is characterized by chronic and low-grade systemic inflammation, an increase of adipose tissue, hypertrophy, and hyperplasia of adipocytes.
Luís Henrique Corrêa, Gabriella Simões Heyn, Kelly Grace Magalhaes   +2 more
doaj   +1 more source

Mycobacterium canettii Infection of Adipose Tissues

Frontiers in Cellular and Infection Microbiology, 2017
Adipose tissues were shown to host Mycobacterium tuberculosis which is persisting inside mature adipocytes. It remains unknown whether this holds true for Mycobacterium canettii, a rare representative of the M.
Fériel Bouzid, Fériel Bouzid, Fabienne Brégeon, Fabienne Brégeon, Isabelle Poncin, Pascal Weber, Michel Drancourt, Stéphane Canaan   +7 more
doaj   +1 more source

CDK6 inhibits white to beige fat transition by suppressing RUNX1

Nature Communications, 2018
Beige adipocytes can arise from transdifferentiation of mature white adipocytes. Here the authors identify CDK6 as a key molecule involved in the white-to-beige adipocyte transdifferentiation and, therefore, as a regulator of organismal energy ...
Xiaoli Hou, Yongzhao Zhang, Wei Li, Alexander J. Hu, Chi Luo, Wenhui Zhou, Jamie K. Hu, Stefano G. Daniele, Jinfeng Wang, Jinghao Sheng, Yongsheng Fan, Andrew S. Greenberg, Stephen R. Farmer, Miaofen G. Hu   +13 more
doaj   +1 more source

Sphingomyelin is involved in regulating UCP1-mediated nonshivering thermogenesis

Journal of Lipid Research
Adipogenesis is one of the major mechanisms for adipose tissue expansion, during which spindle-shaped mesenchymal stem cells commit to the fate of adipocyte precursors and differentiate into round-shaped fat-laden adipocytes.
Detian Hu, Houyu Zhang, Zhen Liu, Carlos F. Ibáñez, Cai Tie, Meng Xie   +5 more
doaj   +1 more source

Integrative analyses of translatome and transcriptome reveal important translational controls in brown and white adipose regulated by microRNAs

Scientific Reports, 2017
The epidemic of obesity and diabetes has markedly spurred the research interest in adipocyte biology. Brown adipocytes are specialized for energy expenditure and of therapeutic interest for treatment of metabolic diseases, but how brown adipocytes are ...
David W. Reid, Dan Xu, Peng Chen, Hongyuan Yang, Lei Sun   +4 more
doaj   +1 more source

The lipidome of primary murine white, brite, and brown adipocytes-Impact of beta-adrenergic stimulation.

PLoS Biology, 2019
Lipid species patterns are conserved within cells to maintain physicochemical properties of membranes and cellular functions. We present the lipidome, including sterols, glycerolipids (GLs), glycerophospholipids (GPLs), and sphingolipids (SLs), of ...
Sabine Schweizer, Gerhard Liebisch, Josef Oeckl, Marcus Hoering, Claudine Seeliger, Carolin Schiebel, Martin Klingenspor, Josef Ecker   +7 more
doaj   +1 more source

Perirenal adipose tissue contains a subpopulation of cold-inducible adipocytes derived from brown-to-white conversion

eLife
Perirenal adipose tissue (PRAT) is a unique visceral depot that contains a mixture of brown and white adipocytes. The origin and plasticity of such cellular heterogeneity remains unknown.
Houyu Zhang, Yan Li, Carlos F Ibáñez, Meng Xie   +3 more
doaj   +1 more source