Results 61 to 70 of about 62,660 (267)

White adipocytes are less prone to apoptotic stimuli than brown adipocytes in rodent [PDF]

Cell Death & Differentiation, 2006
n ...
E. Nisoli, A. Cardile, A. Bulbarelli, L. Tedesco, R. Bracale, V. Cozzi, M. Morroni, S. Cinti, A. Valerio, M.O. Carruba   +9 more
openaire   +5 more sources

HOXC10 suppresses browning to maintain white adipocyte identity

Diabetes, 2021
Promoting beige adipocyte development within white adipose tissue (WAT) is a potential therapeutic approach to staunch the current obesity epidemic. Previously, we identified homeobox-containing transcription factor HOXC10 as a suppressor of browning in subcutaneous WAT.
H.Y. Angeline Tan, M.F. Michelle Sim, Shi-Xiong Tan, Yvonne Ng, Sin Yee Gan, Hongyu Li, Suat Peng Neo, Jayantha Gunaratne, Feng Xu, Weiping Han   +9 more
openaire   +4 more sources

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

A Novel Perfused Full‐Thickness Human Skin Microphysiological System for Modeling Injury, Regeneration, Tumor Pathophysiology, and Therapeutics Development

Advanced Healthcare Materials, EarlyView.
What if human skin could remain fully alive and functional outside the body for weeks? A New Alternative Method (NAM) based on a vascularized full‐thickness skin microphysiological system achieves precisely this, preserving native vasculature, resident immunity, and metabolic activity for up to three weeks, while faithfully recapitulating radiation ...
Yusuf Surucu, Hamid Malekzadeh, Alexa Rivera Del Rio Hernandez, Naresh Mahajan, Ethan Banks, Dayyan Ur Rahman, José A. Arellano, Katherine S. Yang, Alexey Altman, G.V. Naveen Kumar, Matthew L. Steinhauser, Jeffrey A. Gusenoff, J. Peter Rubin, Asim Ejaz   +13 more
wiley   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes

Cell Reports, 2017
White adipocytes are specialized for energy storage, whereas brown adipocytes are specialized for energy expenditure. Explicating this difference can help identify therapeutic targets for obesity.
Alfred K. Ramirez, Matthew D. Lynes, Farnaz Shamsi, Ruidan Xue, Yu-Hua Tseng, C. Ronald Kahn, Simon Kasif, Jonathan M. Dreyfuss   +7 more
doaj   +1 more source

Isoliquiritigenin Enhances the Beige Adipocyte Potential of Adipose-Derived Stem Cells by JNK Inhibition

Molecules, 2020
Human adipose-derived stem cells (hASCs) can be isolated from fat tissue and have attracted interest for their potential therapeutic applications in metabolic disease.
Hanbyeol Moon, Jung-Won Choi, Byeong-Wook Song, Il-Kwon Kim, Soyeon Lim, Seahyoung Lee, Ki-Chul Hwang, Sang Woo Kim   +7 more
doaj   +1 more source

Bmp4 Promotes a Brown to White-like Adipocyte Shift [PDF]

Cell Reports, 2016
ISSN:2211 ...
Modica, Salvatore, Straub, Leon G., Balaz, Miroslav, Sun, Wenfei, Varga, Lukas, Stefanicka, Patrik, Profant, Milan, Simon, Eric, Neubauer, Heike, Ukropcova, Barbara, Ukropec, Jozef, Wolfrum, Christian   +11 more
openaire   +5 more sources

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

Peritumoral adipose tissue promotes lipolysis and white adipocytes browning by paracrine action

Frontiers in Endocrinology, 2023
BackgroundStromal adipocytes and tumor breast epithelial cells undergo a mutual metabolic adaptation within tumor microenvironment. Therefore, browning and lipolysis occur in cancer associated adipocytes (CAA).
Priscila Pagnotta, Priscila Pagnotta, Mariana Gantov, Sabrina Fletcher, Antonella Lombardi, María Lujan Crosbie, Natalia Santiso, Anabela Ursino, Celeste Frascarolli, Alicia Amato, Rubén Dreszman, Juan Carlos Calvo, Juan Carlos Calvo, Judith Toneatto   +13 more
doaj   +1 more source