Basal and PGF2α-stimulated secretion of pro-inflammatory cytokines from 3T3-L1 adipocyte-like cells [PDF]
BioDiscovery, 2017 Adipocytes were recently identified as an important source of endocrine and paracrine mediators, regulating the metabolism and activity of various cell types and body functions. 3T3-L1 preadipocytes are useful model for physiological, pharmacological and
Bilyana Ilieva +3 more
doaj +3 more sources
Extracting quantitative biological information from brightfield cell images using deep learning [PDF]
, 2020 Quantitative analysis of cell structures is essential for biomedical and pharmaceutical research. The standard imaging approach relies on fluorescence microscopy, where cell structures of interest are labeled by chemical staining techniques. However, these techniques are often invasive and sometimes even toxic to the cells, in addition to being time ...
arxiv +1 more source
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. [PDF]
, 2015 The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute
Ahmadian, Maryam +16 more
core +2 more sources
Adipocytes Provide Fatty Acids to Acute Lymphoblastic Leukemia Cells
Frontiers in Oncology, 2021 BackgroundThere is increasing evidence that adipocytes play an active role in the cancer microenvironment. We have previously reported that adipocytes interact with acute lymphoblastic leukemia (ALL) cells, contributing to chemotherapy resistance and ...
Jonathan Tucci +17 more
doaj +1 more source
Transcriptome Modifications in Porcine Adipocytes via Toll-Like Receptors Activation [PDF]
, 2019 Adipocytes are the most important cell type in adipose tissue playing key roles in immunometabolism. We previously reported that nine members of the Toll-like receptor (TLR) family are expressed in an originally established porcine intramuscular pre ...
Albarracín, Leonardo Miguel +13 more
core +1 more source
Computational modeling of the physical features that influence breast cancer invasion into adipose tissue [PDF]
APL Bioengineering 8 (2024) 036104Breast cancer invasion into adipose tissue strongly influences disease progression and metastasis. The degree of cancer cell invasion into adipose tissue depends on numerous biochemical and physical properties of cancer cells, adipocytes, and other key components of adipose tissue.
arxiv +1 more source
Evidence of mature adipocyte proliferation regulated by proliferin [PDF]
, 2010 Despite much research, whether mature adipocytes proliferate remains controversial. Here, we examined 5-bromo-2′-deoxyuridine (BrdU)-labelling of mature adipocytes.
Aki Minami +16 more
core +1 more source
Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation. [PDF]
, 2014 Chronic low-grade inflammation is emerging as a pathogenic link between obesity and metabolic disease. Persistent immune activation in white adipose tissue (WAT) impairs insulin sensitivity and systemic metabolism, in part, through the actions of ...
Cheng, Ji-Xin +10 more
core +2 more sources
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Mediators of Inflammation, 2017 Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages.
Louisa Dowal +13 more
doaj +1 more source