Results 61 to 70 of about 28,208 (288)
Advanced Science, EarlyView.Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu +10 more
wiley +1 more source
Frontiers in NeuroscienceBackgroundC1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a novel adipokine that has been shown to exert neuroprotective effects in acute cerebral infarction.
Qingsheng Niu +7 more
doaj +1 more source
Advanced Science, EarlyView.This study demonstrates that the imbalance between osteogenic and adipogenic differentiation in senescent BMSCs, leading to excessive adipocyte accumulation, which subsequently impairs bone regeneration in aged mice. To address this pathological dysregulation, a novel energy‐supplying hydrogel system (PBR) has been developed to restore balanced ...
Zirui He +7 more
wiley +1 more source
Veterinary Medicine and Science, 2022 Background Peripheral blood mononuclear cells (PBMCs) have been identified as a possible marker of inflammation in obesity. Understanding the expression of pro‐ and anti‐inflammatory cytokines in PBMCs in obese dogs will help control obesity‐related ...
Seo‐Young Hwang +7 more
doaj +1 more source
TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism
Nature Metabolism, 2018 Exercise improves health and well-being across diverse organ systems, and elucidating mechanisms underlying the beneficial effects of exercise can lead to new therapies.
Hirokazu Takahashi +25 more
semanticscholar +1 more source
Advanced Science, EarlyView.Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély +5 more
wiley +1 more source
More Than an Adipokine: The Complex Roles of Chemerin Signaling in Cancer
International Journal of Molecular Sciences, 2019 Chemerin is widely recognized as an adipokine, with diverse biological roles in cellular differentiation and metabolism, as well as a leukocyte chemoattractant.
K. Goralski +3 more
semanticscholar +1 more source
Adipokines in rheumatoid arthritis [PDF]
Advances in Rheumatology, 2018 Rheumatoid arthritis affects millions of people worldwide and is considered a chronic multisystem disease whose causes are unknown. In general, the main objective of rheumatoid arthritis treatment is to improve the quality of life of patients by relieving pain, maintaining or improving functional capacity, preventing thus, disability.
Elis Carolina de Souza Fatel +3 more
openaire +3 more sources
Obesity, adipokines and COVID‐19 [PDF]
European Journal of Clinical Investigation, 2020 The SARS-CoV-2 pandemic has led to worldwide research aiming to identify the risk factors for developing critical illness and mortality caused by COVID-19. It quickly became apparent that besides older age, obesity is one of the most important risk factors for a more severe course of COVID-19, although the mechanisms remain largely unknown [1-3 ...
Post, Adrian +2 more
openaire +2 more sources
Animal Models and Experimental Medicine, EarlyView.Adropin is related to the energy homeostasis‐associated gene. It significantly increased glutathione reductase enzyme levels in the pancreas of experimental diabetic rats. Adropin may reduce the severity of diabetes and its complications. Cell proliferation in the exocrine is reduced after the administration of adropin.
Ifrah I. Ali +4 more
wiley +1 more source