Results 191 to 200 of about 91,644 (264)

Multiomics Insights Into AL Amyloidosis

Medicine Bulletin, EarlyView.
ABSTRACT Light chain amyloidosis is a systemic or localized protein conformational disorder triggered by misfolded immunoglobulin light chains, leading to amyloid fibril deposition. The disease is characterized by multiorgan involvement and delayed diagnosis, contributing to poor prognosis and high mortality rates.
Zixuan Zhang, Ziru Huang, Haoxiang Tang, Xianrun Pan, Rong Wang, Dingding Zhang, Jian Huang   +6 more
wiley   +1 more source

Low-intensity pulsed ultrasound regulates the osteogenic-adipogenic differentiation balance of rat adipose-derived stem cells via the PI3K/AKT-SREBF1 signaling axis. [PDF]

Stem Cells Transl Med
Hu W, Zhao Z, Zhang Q, Gong P, Wang X, Han C, Gao X, Long J.   +7 more
europepmc   +1 more source

Osteoarthritis: An Immuno‐Inflammatory Disease‐Mechanisms of Immune Cell Dysregulation and Potential Therapeutic Strategies

Med Research, EarlyView.
This review summarizes the immuno‐inflammatory mechanisms driving the pathogenesis of osteoarthritis (OA), extending beyond the traditional view of OA as a purely degenerative disease to incorporate immune cell infiltration, inflammatory factor release, and the formation of a chronic low‐grade inflammatory microenvironment.
Qingqiang Lei, Xiaoxian Lou, Xu Su, Shubao Liu, Yanli Tong, Jie Chen, Xuerui Chen, Wenjun Mao, Hui Yu, Liangbin Lin   +9 more
wiley   +1 more source

Pivotal contribution of super-enhancer-driven KLF6 expression to the adipogenesis of human adipose-derived stem cells. [PDF]

Inflamm Regen
Nguyen MP, Yamagata K, Nguyen AP, Zhang T, Sakai H, Ngo UT, Shan Y, Otsuka T, Huong NTD, Aritomi T, Yuan M, Kato S, Tanaka Y, Nakayamada S.   +13 more
europepmc   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

From Fat to Healing: How Adipose-Derived Stem Cells Are Changing the Game for Diabetic Foot Ulcers-A Perspective. [PDF]

Health Sci Rep
Nagarajan P, Rajarathinam M, Jayakumar AD, Thirumal P, Rangarajalu K, Perumal N, Muthiah P, Howlader A.   +7 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

The antibacterial effect of human adipose-derived stem cells on LL-37-resistant bacteria. [PDF]

PLoS One
Afzal Haghjoo P, Mojtahedi A, Ansar MM, Ansar MM, Danesh Mobarhan S.   +4 more
europepmc   +1 more source

Recent Advances in Cryogel Applications for Musculoskeletal Regeneration

Medicinal Research Reviews, EarlyView.
ABSTRACT Hydrogels have been widely used in tissue engineering due to their high‐water content and biocompatibility, yet their densely cross‐linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels, formed through partial freezing and crosslinking under subzero conditions, provide unique 3D macroporous
Dohee Kim, Shinwon Kang, Hyejin Jo, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Extracellular vesicles from human adipose-derived stem cells relieve pain and inflammation in a rat model of knee osteoarthritis. [PDF]

Stem Cell Res Ther
Kim WS, Woo CH, Lee KS, Choi YC, Yun YE, Choi JS, Cho YW.   +6 more
europepmc   +1 more source