Results 1 to 10 of about 373,606 (268)

Timing of Adiposity Rebound and Adiposity in Adolescence [PDF]

PEDIATRICS, 2014
To investigate associations between timing of adiposity rebound (AR; the period in childhood where BMI begins to increase from its nadir) and adiposity (BMI, fat mass) at age 15 years in the Avon Longitudinal Study of Parents and Children (ALSPAC).The sample consisted of 546 children with AR derived in childhood and BMI and fat mass index (FMI; fat ...
Hughes, Adrienne, Sherriff, Andrea, Ness, Andrew R., Reilly, John   +3 more
openaire   +5 more sources

Thermoneutral housing promotes hepatic steatosis in standard diet-fed C57BL/6N mice, with a less pronounced effect on NAFLD progression upon high-fat feeding

Frontiers in Endocrinology, 2023
IntroductionNon-alcoholic fatty liver disease (NAFLD) can progress to more severe stages, such as steatohepatitis and fibrosis. Thermoneutral housing together with high-fat diet promoted NAFLD progression in C57BL/6J mice.
Olga Horakova, Gabriella Sistilli, Gabriella Sistilli, Veronika Kalendova, Veronika Kalendova, Kristina Bardova, Marko Mitrovic, Marko Mitrovic, Tomas Cajka, Ilaria Irodenko, Petra Janovska, Karoline Lackner, Jan Kopecky, Martin Rossmeisl   +13 more
doaj   +1 more source

Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat

Disease Models & Mechanisms, 2022
Impaired thermogenesis observed in mice with whole-body ablation of peroxisome proliferator-activated receptor-γ coactivator-1β (PGC-1β; officially known as PPARGC1B) may result from impaired brown fat (brown adipose tissue; BAT) function, but other ...
Jiří Funda, Josep A. Villena, Kristina Bardova, Katerina Adamcova, Illaria Irodenko, Pavel Flachs, Ivana Jedlickova, Eliska Haasova, Martin Rossmeisl, Jan Kopecky, Petra Janovska   +10 more
doaj   +1 more source

Childhood adiposity, adult adiposity, and bone health [PDF]

Pediatric Investigation, 2021
ABSTRACTImportanceChildhood and adolescence are critical periods for lifelong bone mineral accrual, but few studies have determined the impact of childhood adiposity on adult bone density.ObjectiveTo determine the long‐term impact of childhood adiposity on adult areal bone mineral density (aBMD) and the effect of adult adiposity on this relationship ...
Hongbo Dong, Xiaoyuan Zhao, Hong Cheng, Jie Mi   +3 more
openaire   +3 more sources

Visualizing Cathepsin K‐Cre Expression at the Single‐Cell Level with GFP Reporters

JBMR Plus, 2023
The Cre/lox system is a fundamental tool for functional genomic studies, and a number of Cre lines have been generated to target genes of interest spatially and temporally in defined cells or tissues; this approach has greatly expanded our knowledge of ...
Wenhuan Chai, Weiwei Hao, Jintao Liu, Zhenglin Han, Shiyu Chang, Liben Cheng, Mingxin Sun, Guofang Yan, Zemin Liu, Yin Liu, Guodong Zhang, Li Xing, Hongqian Chen, Peng Liu   +13 more
doaj   +1 more source

A pyrexic effect of FGF21 independent of energy expenditure and UCP1

Molecular Metabolism, 2021
Objective: Administration of FGF21 to mice reduces body weight and increases body temperature. The increase in body temperature is generally interpreted as hyperthermia, i.e.
Petr Zouhar, Petra Janovska, Sara Stanic, Kristina Bardova, Jiri Funda, Blanka Haberlova, Birgitte Andersen, Martin Rossmeisl, Barbara Cannon, Jan Kopecky, Jan Nedergaard   +10 more
doaj   +1 more source

Impairment of adrenergically-regulated thermogenesis in brown fat of obesity-resistant mice is compensated by non-shivering thermogenesis in skeletal muscle

Molecular Metabolism, 2023
Objective: Non-shivering thermogenesis (NST) mediated by uncoupling protein 1 (UCP1) in brown adipose tissue (BAT) can be activated via the adrenergic system in response to cold or diet, contributing to both thermal and energy homeostasis.
Petra Janovska, Petr Zouhar, Kristina Bardova, Jakub Otahal, Marek Vrbacky, Tomas Mracek, Katerina Adamcova, Lucie Lenkova, Jiri Funda, Tomas Cajka, Zdenek Drahota, Sara Stanic, Arild C. Rustan, Olga Horakova, Josef Houstek, Martin Rossmeisl, Jan Kopecky   +16 more
doaj   +1 more source

Spatiotemporal contact between peroxisomes and lipid droplets regulates fasting-induced lipolysis via PEX5

Nature Communications, 2020
Lipid droplets are organelles that regulate lipid metabolism but if organellar contacts play a role during lipolysis is unclear. Here, the authors show that peroxisomes and peroxisomal protein PEX5 play pivotal roles in the spatial and temporal ...
Jinuk Kong, Yul Ji, Yong Geun Jeon, Ji Seul Han, Kyung Hee Han, Jung Hyun Lee, Gung Lee, Hagoon Jang, Sung Sik Choe, Myriam Baes, Jae Bum Kim   +10 more
doaj   +1 more source

Indices of Adiposity [PDF]

Journal of Epidemiology & Community Health, 1962
In a clinical context, the term "overweight" usually connotes adiposity, an excess of body fat. In the absence of any direct or simple indirect methods of measuring total body fat, medical research workers often use formulae (indices) which relate body weight to stature.
W Z, BILLEWICZ, W F, KEMSLEY, A M, THOMSON   +2 more
openaire   +2 more sources

Stem Cell Transplantation Therapy: A Potential Method for Treating Cytokine Storm Syndromes Induced by COVID-19

Cell Transplantation, 2020
Novel therapies are urgently needed to combat the severe cytokine storm syndromes induced by coronavirus disease 2019 (COVID-19). An increasing number of preclinical and clinical investigations of stem cell and derivatives therapy for COVID-19 were being
Hayson Chenyu Wang, Xiaojun Wang, Xiao Long   +2 more
doaj   +1 more source