Macrophages Mediate Increased CD8 T Cell Inflammation During Weight Loss in Formerly Obese Mice
Frontiers in Endocrinology, 2020 Even after successful weight reduction, obese adults tend to quickly regain the lost weight. This raises the question of whether weight loss improves the underlying chronic adipose tissue inflammation characteristic of obesity.
Jayagopi Surendar +6 more
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Nature Communications, 2016 The clock protein Cry regulates hepatic glucose metabolism. Here the authors show that SREBP1c, activated by insulin signalling after feeding, directly regulates Cry transcription at specific circadian time points, and that Cry represses hepatic glucose ...
Hagoon Jang +11 more
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A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences [PDF]
, 2010 Depot-dependent differences in adipose tissue physiology may reflect specialized functions and local interactions between adipocytes and surrounding tissues.
Kelder, T.A.J. +46 more
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Frontiers in Molecular Biosciences, 2020 Obesity and overweight are common modern health challenges. Caloric intake greater than that needed for energy production results in excess storage of fat in the abdomen.
Yaliang Zhou, Chunlu Tan
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Parallels in Immunometabolic Adipose Tissue Dysfunction with Ageing and Obesity
Frontiers in Immunology, 2018 Ageing, like obesity, is often associated with alterations in metabolic and inflammatory processes resulting in morbidity from diseases characterised by poor metabolic control, insulin insensitivity, and inflammation.
William Trim +2 more
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The defense of adipose tissue against excess substrate-induced hyperthrophia: Immune system cell infiltration and arrested metabolic activity [PDF]
, 2011 Obesity, the excessive accumulation of body fat, is a main defining feature of the metabolic syndrome, and overweight is often an early indication of the future severity and development of associated pathologies.
Alemany, Marià, 1946-, Marià Alemany
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Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans
Frontiers in Cardiovascular Medicine, 2023 IntroductionVascular dysfunction and chronic inflammation are characteristics of obesity-induced adipose tissue dysfunction. Proinflammatory cytokines can drive an endothelial-to-mesenchymal transition (EndoMT), where endothelial cells undergo a ...
Nicholas W. Chavkin +10 more
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Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The anti-angiogenic herbal composition Ob-X inhibits adipose tissue growth in obese mice [PDF]
, 2009 Objective: The growth and development of adipose tissue are thought to be associated with angiogenesis and extracellular matrix remodeling. Since the composition of the herbal extract called Ob-X has been shown to have both anti-angiogenic and matrix ...
Min-Young Kim +9 more
core
The PPARy ligand rosiglitazone influences triacylglycerol metabolism in non-obese males, without increasing the transcriptional activity of PPARy in the subcutaneous adipose tissue [PDF]
, 2008 PPAR¿ is obligatory for fat mass generation and is thought to determine the amount of TAG stored per fat cell. We investigated whether ligand availability for PPAR¿ is rate limiting in fat mass generation and substrate metabolism.
Kersten, A.H. +3 more
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