Results 31 to 40 of about 373,606 (268)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Reconstituted high-density lipoprotein infusion modulates fatty acid metabolism in patients with type 2 diabetes mellitus

Journal of Lipid Research, 2011
We recently demonstrated that reconstituted high-density lipoprotein (rHDL) modulates glucose metabolism in humans via both AMP-activated protein kinase (AMPK) in muscle and by increasing plasma insulin.
Brian G. Drew, Andrew L. Carey, Alaina K. Natoli, Melissa F. Formosa, Donna Vizi, Medini Reddy-Luthmoodoo, Jacquelyn M. Weir, Christopher K. Barlow, Gerrit van Hall, Peter J. Meikle, Stephen J. Duffy, Bronwyn A. Kingwell   +11 more
doaj   +1 more source

The adipose organ: morphological perspectives of adipose tissues [PDF]

Proceedings of the Nutrition Society, 2001
Anatomically, an organ is defined as a series of tissues which jointly perform one or more interconnected functions. The adipose organ qualifies for this definition as it is made up of two tissue types, the white and brown adipose tissues, which collaborate in partitioning the energy contained in lipids between thermogenesis and the other metabolic ...
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Distinct cellular and molecular mechanisms for β3 adrenergic receptor-induced beige adipocyte formation

eLife, 2017
Beige/brite adipocytes are induced within white adipose tissues (WAT) and, when activated, consume glucose and fatty acids to produce heat. Classically, two stimuli have been used to trigger a beiging response: cold temperatures and β3-adrenergic ...
Yuwei Jiang, Daniel C Berry, Jonathan M Graff   +2 more
doaj   +1 more source

Childhood Adiposity, Adult Adiposity, and Cardiovascular Risk Factors

New England Journal of Medicine, 2011
Obesity in childhood is associated with increased cardiovascular risk. It is uncertain whether this risk is attenuated in persons who are overweight or obese as children but not obese as adults.We analyzed data from four prospective cohort studies that measured childhood and adult body-mass index (BMI, the weight in kilograms divided by the square of ...
Juonala, M, Magnussen, CG, Berenson, GS, Venn, A, Burns, TL, Sabin, MA, Srinivasan, SR, Daniels, SR, Davis, PH, Chen, W, Sun, C, Cheung, M, Viikari, JSA, Dwyer, T, Raitakari, OT   +14 more
openaire   +5 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Refinements in adipose tissue biopsy collection in shorebirds: effect on pain, wound healing, and mass gain

Journal of Field Ornithology, 2023
Non-lethal methods to sample adipose tissues from fat depots in small birds are highly valuable as a time integrated sample matrix for ecotoxicology and ecophysiology research.
Christy Morrissey, Kurtis Swekla
doaj  

Ambient particulate air pollution induces oxidative stress and alterations of mitochondria and gene expression in brown and white adipose tissues

Particle and Fibre Toxicology, 2011
Background Prior studies have demonstrated a link between air pollution and metabolic diseases such as type II diabetes. Changes in adipose tissue and its mitochondrial content/function are closely associated with the development of insulin resistance ...
Harkema Jack R, Wang Aixia, Yang Yifeng, Bramble Lori A, Wagner James G, Lewandowski Ryan P, Hotchkiss Ian P, Zhong Mianhua, Xu Xiaohua, Xu Zhaobin, Lippmann Morton, Rajagopalan Sanjay, Chen Lung-Chi, Sun Qinghua   +13 more
doaj   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source