Results 81 to 90 of about 4,507,088 (388)

Association of 11β-hydroxysteroid dehydrogenase type I expression and activity with estrogen receptor β in adipose tissue from postmenopausal women [PDF]

, 2012
OBJECTIVE: 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) regenerates active cortisol from inert cortisone in adipose tissue. Elevated adipose tissue 11βHSD1 activity is observed in obese humans and rodents where it is linked to obesity and its ...
Cecilia Mattsson, Dieudonne, Heine, Horenburg, Hughes, Ingegerd Söderström, Jonathan R. Seckl, Kerry J. McInnes, Kotryna Šimonytė, McInnes, Sierens, Sorensen, Therése C. Andersson, Tommy Olsson, Walker   +14 more
core   +1 more source

Identification of a mesenchymal progenitor cell hierarchy in adipose tissue

Science, 2019
A singular focus on fat Fatty tissue can expand in two ways: through increases in the size of individual adipocytes or through increases in the number of adipocytes.
David Merrick, Alexander Sakers, Zhazira Irgebay, Chihiro Okada, C. Calvert, M. Morley, I. Percec, P. Seale   +7 more
semanticscholar   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

Unique adipose tissue invariant natural killer T cell subpopulations control adipocyte turnover in mice

Nature Communications, 2023
Adipose tissue invariant natural killer T (iNKT) cells are a crucial cell type for adipose tissue homeostasis in obese animals. However, heterogeneity of adipose iNKT cells and their function in adipocyte turnover are not thoroughly understood.
Sang Mun Han, Eun Seo Park, Jeu Park, Hahn Nahmgoong, Yoon Ha Choi, Jiyoung Oh, Kyung Min Yim, Won Taek Lee, Yun Kyung Lee, Yong Geun Jeon, Kyung Cheul Shin, Jin Young Huh, Sung Hee Choi, Jiyoung Park, Jong Kyoung Kim, Jae Bum Kim   +15 more
doaj   +1 more source

Adipose Tissue Is a Neglected Viral Reservoir and an Inflammatory Site during Chronic HIV and SIV Infection [PDF]

, 2015
International audienceTwo of the crucial aspects of human immunodeficiency virus (HIV) infection are (i) viral persistence in reservoirs (precluding viral eradication) and (ii) chronic inflammation (directly associated with all-cause morbidities in ...
Avettand-Fenoël, Véronique, Benoist, Stéphane, Bourgeois, Christine, Béréziat, Véronique, Capeau, Jacqueline, Cosma, Antonio, Damouche, Abderaouf, David, Ludivine, Dejucq-Rainsford, Nathalie, Dereuddre-Bosquet, Nathalie, Favier, Benoît, Ghosn, Jade, Gommet, Céline, Huot, Nicolas, Lambotte, Olivier, Lazure, Thierry, Le Grand, Roger, Martinez, Valérie, Mélard, Adeline, Müller-Trutwin, Michaela, Noel, Nicolas, Pourcher, Guillaume, Rouzioux, Christine, Satie, Anne-Pascale, Vaslin, Bruno   +24 more
core   +6 more sources

Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome.

Journal of Clinical Investigation, 2019
Over the past decade, great progress has been made in understanding the complexity of adipose tissue biology and its role in metabolism. This includes new insights into the multiple layers of adipose tissue heterogeneity, not only differences between ...
C. Kahn, Guoxiao Wang, Kevin Y. Lee, Kevin Y. Lee   +3 more
semanticscholar   +1 more source

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Differential regulation of gene co-expression modules in muscles and liver of preterm newborns

Frontiers in Cell and Developmental Biology
BackgroundNewborns undergo rapid metabolic and organ adaptations after birth, which are compromised in premature newborns, leading to adverse health outcomes.
Petra Janovska, Tatyana Kobets, Lenka Steiner Mrazova, Lenka Steiner Mrazova, Michaela Svobodova, Marketa Tesarova, Pavel Kopecky, Petr Zouhar, Martin Rossmeisl, Viktor Stranecky, Stanislav Kmoch, Jan Kopecky   +11 more
doaj   +1 more source

15-LOX metabolites and angiogenesis: angiostatic effect of 15(S)-HPETE involves induction of apoptosis in adipose endothelial cells [PDF]

PeerJ, 2014
Inflammation is critical in the dysregulated growth of adipose tissue and associated vascular dysfunctions. 15-Lipoxygenase metabolites, important mediators of inflammation in adipose tissue during obese conditions, may contribute to codependence of ...
Sasikumar J. Soumya, Sheela Binu, Antony Helen, Pallu Reddanna, Perumana R. Sudhakaran   +4 more
doaj   +2 more sources

In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy [PDF]

, 2014
Obesity increases preeclampsia risk, and maternal dyslipidemia may result from exaggerated adipocyte lipolysis. We compared adipocyte function in preeclampsia with healthy pregnancy to establish whether there is increased lipolysis.
Forrest, Rachel., Freeman, Dilys J., Huda, Shahzya S., Jordan, Fiona, Paterson, Nicole, Sattar, Naveed   +5 more
core   +1 more source