Results 21 to 30 of about 1,840,318 (295)

Functional Inactivation of Mast Cells Enhances Subcutaneous Adipose Tissue Browning in Mice

Cell Reports, 2019
Summary: Adipose tissue browning and systemic energy expenditure provide a defense mechanism against obesity and associated metabolic diseases. In high-cholesterol Western diet-fed mice, mast cell (MC) inactivation ameliorates obesity and insulin ...
Xian Zhang, Xin Wang, Hao Yin, Lei Zhang, Airong Feng, Qiu-Xia Zhang, Yan Lin, Bin Bao, Laura L. Hernandez, Guo-Ping Shi, Jian Liu   +10 more
doaj   +1 more source

NRF2 is essential for adaptative browning of white adipocytes

Redox Biology, 2023
White adipose tissue browning, defined by accelerated mitochondrial metabolism and biogenesis, is considered a promising mean to treat or prevent obesity-associated metabolic disturbances.
Marco Bauzá-Thorbrügge, Eduard Peris, Shabnam Zamani, Peter Micallef, Alexandra Paul, Stefano Bartesaghi, Anna Benrick, Ingrid Wernstedt Asterholm   +7 more
doaj   +1 more source

E0771 and 4T1 murine breast cancer cells and interleukin 6 alter gene expression patterns but do not induce browning in cultured white adipocytes

Biochemistry and Biophysics Reports, 2019
Breast cancer remains a substantial clinical problem worldwide, and cancer-associated cachexia is a condition associated with poor prognosis in this and other malignancies.
Janina V. Pearce, Jared S. Farrar, Joseph C. Lownik, Bin Ni, Shanshan Chen, Tiffany W. Kan, Francesco S. Celi   +6 more
doaj   +1 more source

Regulation of UCP1 in the Browning of Epididymal Adipose Tissue by β3-Adrenergic Agonist: A Role for MicroRNAs

International Journal of Endocrinology, 2014
Background. White adipose tissue browning may be a promising strategy to combat obesity. UCP1 is strongly induced in White adipose tissue with β3-adrenergic agonist treatment, but the causes of this increase have not been fully elucidated.
Zongji Zheng, Xiaomeng Liu, Qianwei Zhao, Lei Zhang, Chenzhong Li, Yaoming Xue   +5 more
doaj   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate [PDF]

, 2016
Background/Objectives: Short-chain fatty acids, produced by microbiome fermentation of carbohydrates, have been linked to a reduction in appetite, body weight and adiposity.
Sahuri Arisoylu, M., Navaratnam, N., Thomas, E.L., Frost, G.S., Brody, L., Parkinson, J., Bell, J.D., Parkes, H.G., Miller, A.D.   +8 more
core   +1 more source

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

The browning of white adipose tissue and body weight loss in primary hyperparathyroidismResearch in context

EBioMedicine, 2019
Background: Parathyroid hormone related protein (PTHrP) triggers white adipose tissue (WAT) browning and cachexia in lung cancer mouse models. It remains unknown whether excessive PTH secretion affects WAT browning and to what extent it contributes to ...
Yang He, Rui-xin Liu, Min-ting Zhu, Wen-bin Shen, Jing Xie, Zhi-yin Zhang, Na Chen, Chang Shan, Xing-zhi Guo, Yi-de Lu, Bei Tao, Li-hao Sun, Hong-yan Zhao, Rui Guo, Biao Li, Si-min Liu, Guang Ning, Ji-qiu Wang, Jian-min Liu   +18 more
doaj   +1 more source

Epigenetic regulation of white adipose tissue plasticity and energy metabolism by nucleosome binding HMGN proteins

Nature Communications, 2022
White adipose tissue browning plays an important role in regulating whole-body energy homeostasis and metabolism. Here the authors show that the HMGN nucleosome binding proteins epigenetically promote white adipocyte differentiation and modulate the rate
Ravikanth Nanduri, Takashi Furusawa, Alexei Lobanov, Bing He, Carol Xie, Kimia Dadkhah, Michael C. Kelly, Oksana Gavrilova, Frank J. Gonzalez, Michael Bustin   +9 more
doaj   +1 more source

The role of melanocortins and cytokines in human adipose tissue and adipocytes [PDF]

, 2007
During the last decades obesity has become a major health problem in developed countries, and more recently also in the developing countries it is seriously affecting parts of the populations.
Hoch, Matthias
core   +1 more source