Results 41 to 50 of about 14,567 (295)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Ablation of ORMDL3 impairs adipose tissue thermogenesis and insulin sensitivity by increasing ceramide generation

Molecular Metabolism, 2022
Objective: Genome-wide association studies identified ORMDL3 as an obesity-related gene, and its expression was negatively correlated with body mass index.
Yu Song, Wenying Zan, Liping Qin, Shuang Han, Lili Ye, Molin Wang, Baichun Jiang, Pan Fang, Qiji Liu, Changshun Shao, Yaoqin Gong, Peishan Li   +11 more
doaj   +1 more source

Human Brown Adipose Tissue [PDF]

Cell Metabolism, 2010
The BAT organ is unique in that it has evolved to safely dissipate large amounts of chemical energy--a quality that might be harnessed to help humans deal with a dangerously hypercaloric environment and still remain in good health.
openaire   +2 more sources

Fat Grafting Can Induce Browning of White Adipose Tissue [PDF]

, 2018
Background: Fat grafting is commonly used when treating soft-tissue defects. However, much of the basic biology behind fat transfer is still uncovered. Adipocytes can be divided into energy storing white and energy burning brown adipose cells.
Anne M. Saarikko, Pirjo Nuutila, Tomi V. Tervala, Tove J. Grönroos, Kivinen, Katri, Grönroos, Tove J., Pauliina Hartiala, Erika Hoppela, Tervala, Tomi V., Nuutila, Pirjo, Katri Kivinen, Susanna Kauhanen, Hartiala, Pauliina, Hoppela, Erika, Kauhanen, Susanna, Saarikko, Anne M.   +15 more
core   +1 more source

Two key temporally distinguishable molecular and cellular components of white adipose tissue browning during cold acclimation

, 2015
Conversion of white into brown adipose tissue may have important implications in obesity resistance and treatment. Several browning agents or conditions ignite thermogenesis in white adipose tissue (WAT).
Golic, Igor, Korać, Bato, Korac, Aleksandra, Markelic, Milica, Stančić, Ana, Janković, Aleksandra, Otašević, Vesna, Buzadžić, Biljana J., Buzadzic, Biljana, Korać, Bato M.   +9 more
core   +1 more source

Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors [PDF]

, 2017
Formation of beige adipocytes within white adipose tissue enhances energy expenditure, which is a promising strategy to reduce obesity and prevent metabolic symptoms.
Min Du, Fu, Xing, Tian, Qiyu, Zhao, Junxing, Gomez, Noe Alberto, Sophie C Trombetta, Deavila, Jeanene M., Xingwei Liang, Zhixiu Wang, Bo Wang, Du, Min, Qiyu Tian, Noe Alberto Gomez, Xing Fu, Liang, Xingwei, Liang Zhao, Wang, Bo, Junxing Zhao, Mei-Jun Zhu, Zhao, Liang, Wang, Zhixiu, Jeanene M Deavila, Trombetta, Sophie C., Zhu, Mei Jun   +23 more
core   +1 more source

White-to-brown adipose switching promotes bladder cancer progression

Neoplasia: An International Journal for Oncology Research
The invasion of bladder cancer into perivesical adipose tissue represents a watershed event in tumor progression, accompanied by a dramatic deterioration in clinical outcomes.
Mingchao Gao, Chunni Li, Wenjie Li, Junyi Xie, Juntian Long, Mingli Luo, Jintao Hu, Cong Lai, Tianhang Lan, Dongxi Zhu, Wenlong Zhong, Wang He   +11 more
doaj   +1 more source

Pharmacological Activation of Thyroid Hormone Receptors Elicits a Functional Conversion of White to Brown Fat

Cell Reports, 2015
The functional conversion of white adipose tissue (WAT) into a tissue with brown adipose tissue (BAT)-like activity, often referred to as “browning,” represents an intriguing strategy for combating obesity and metabolic disease.
Jean Z. Lin, Alexandro J. Martagón, Stephanie L. Cimini, Daniel D. Gonzalez, David W. Tinkey, Amadeo Biter, John D. Baxter, Paul Webb, Jan-Åke Gustafsson, Sean M. Hartig, Kevin J. Phillips   +10 more
doaj   +1 more source

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

Frontiers in Endocrinology, 2023
Overweight and obesity have become a world-wide problem. However, effective intervention approaches are limited. Brown adipose tissue, which helps maintain body temperature and contributes to thermogenesis, is dependent on uncoupling protein1.
Xiaomeng Liu, Xiaomeng Liu, Zhi Zhang, Zhi Zhang, Yajie Song, Hengchang Xie, Meng Dong, Meng Dong   +7 more
doaj   +1 more source

Surgical injury induces local and distant adipose tissue browning.

, 2016
The adipose organ, which comprises brown, white and beige adipocytes, possesses remarkable plasticity in response to feeding and cold exposure. The development of beige adipocytes in white adipose tissue (WAT), a process called browning, represents a ...
Ozaki, C.K., Tao, M., Corpataux, J.M., Ding, K., Lynch, L., Hine, C., Kristal, B.S., Longchamp, A., Bartelt, A., Mitchell, J.R.   +9 more
core   +1 more source