Results 201 to 210 of about 15,146 (241)

Immunology of Vaccine Adjuvants

2009
In recent times vaccine adjuvants, or immunopotentiators, received abundant attention in the media as critical ingredients of current and future vaccines. Indeed, vaccine adjuvants are recognized to make the difference between competing vaccines based on identical antigens.
Ribeiro, C.M.S., Schijns, V.E.J.C.
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Cytokines as immunological adjuvants

Vaccine, 1992
Various cytokines have been shown to be effective immunological adjuvants in a variety of model systems, enhancing protection induced by viral, bacterial and parasitic vaccines, and increasing parameters of immunity in tumour immunization models and in clinical trials.
A W, Heath, J H, Playfair
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Recombinant cytokines as immunological adjuvants

Immunology & Cell Biology, 1993
SummaryThis paper describes the bacterial expression and purification of bioactive recombinant ovine interleukin‐2 (rovIL‐2), interleukin‐lα (rovlL‐lα) and tumour necrosis factor α. These purified proteins had specific activities in appropriate bioassays of 1 × 107, 1 times; 107 and 1 × 105 U/mg, respectively.
Nash, AD, Lofthouse, SA, Barcham, GJ, Jacobs, HJ, Ashman, K, Meeusen, Ent, Brandon, MR, Andrews, AE   +7 more
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Lithium as an immunologic adjuvant

Medical Hypotheses, 1980
Lithium, an adenylate cyclase inhibitor, stimulates a variety of in vitro indices of immune function, including proliferation of lymphocytes in response to mitogens, rosette formation by T-cells and phagocytosis by macrophages. Lithium enhances these immunologic responses at concentrations comparable to those achieved in patients receiving lithium for ...
L, Shenkman, W, Borkowsky, B, Shopsin
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DDA as an immunological adjuvant

Research in Immunology, 1992
As compared to other adjuvants, DDA is a moderate or strong adjuvant for humoral responses and a strong adjuvant for CMI, especially DTH responses, against different types of antigens and in both laboratory animals and larger animals. DDA can collaborate with other immunomodulating compounds resulting in further enhanced responses.
L A, Hilgers, H, Snippe
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Glycolipids as potential immunologic adjuvants

Journal of Medicinal Chemistry, 1980
A group of 1-thio-beta-L-fucopyranosides containing hexadecane, 9-octadecene, adamantane, 1,2-diphenyltetrafluoroethane, and 3-hexynyl- and 3,6-dioxaoctylcholesterols were synthesized as potential immunologic adjuvants. Many of these fucosyl lipids and 6-(5-cholesten-3 beta-yloxy)hexyl 1 thioglycosides were found to give good response to subunit A ...
M M, Ponpipom, R L, Bugianesi, T Y, Shen, A, Friedman   +3 more
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Glucans as Immunological Adjuvants

1995
β-1,3-Linked glucopyranose (β-glucan), a major structural component of yeast, fungi, and algae [1], has a wide range of biological activities. Systemic administration of β-glucan (1) provides nonspecific resistance in experimental animals against a variety of pathogenic challenges [2–7]; (2) prolongs the survival time of tumor-bearing animals [8,9]; (3)
N. Mohagheghpour, M. Dawson, P. Hobbs, A. Judd, R. Winant, L. Dousman, N. Waldeck, L. Hokama, D. Tusé, F. Kos, C. Benike, E. Engleman   +11 more
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Adjuvant-free immunological manipulation of livestock

Research in Veterinary Science, 1984
Mice and sheep were immunised to growth hormone release inhibiting hormone (GHRIH) using a number of systems which avoided conventional adjuvants. GHRIH was linked directly, or via a horse IgG carrier, to algin or purified protein derivative of tuberculin. A conjugate of GHRIH and flagella from Salmonella dublin was also prepared.
C A, Morrison, J, Williams, B N, Perry
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Immunology of TLR-independent vaccine adjuvants

Current Opinion in Immunology, 2009
Vaccine adjuvants target the innate immune system to enhance the immunogenicity of coadministered antigens. Dendritic cells (DCs) are responsible for antigen uptake and presentation to naïve T cells and represent a key target of adjuvant activity. Adjuvants derived from microbial components, such as Toll-like receptor (TLR) agonists, elicit innate ...
Ennio, De Gregorio, Ugo, D'Oro, Andreas, Wack   +2 more
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Co-stimulatory agonists as immunological adjuvants

Vaccine, 2006
The considerable advances made in the fields of molecular biology, genomics, proteomics and protein engineering have led to the identification of a vast range of potential vaccine antigens for a host of man's most serious diseases. However, experience informs us that vaccines based on recombinant proteins and synthetic peptides lack the immunogenicity ...
Tom A, Barr, Jennifer, Carlring, Andrew W, Heath   +2 more
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