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TLR Agonists as Vaccine Adjuvants Targeting Cancer and Infectious Diseases
Pharmaceutics, 2021 Modern vaccines have largely shifted from using whole, killed or attenuated pathogens to being based on subunit components. Since this diminishes immunogenicity, vaccine adjuvants that enhance the immune response to purified antigens are critically ...
Marina Luchner, S. Reinke, A. Milicic
semanticscholar +1 more source
Manganese salts function as potent adjuvants
Cellular & Molecular Immunology, 2021 Aluminum-containing adjuvants have been used for nearly 100 years to enhance immune responses in billions of doses of vaccines. To date, only a few adjuvants have been approved for use in humans, among which aluminum-containing adjuvants are the only ...
Rui Zhang +12 more
semanticscholar +1 more source
Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action
Nature Reviews Chemistry, 2021 Modern subunit vaccines based on homogeneous antigens offer more precise targeting and improved safety compared with traditional whole-pathogen vaccines.
Carlo Pifferi +2 more
semanticscholar +1 more source
Pharmaceutics, 2022 Vaccines are powerful tools for controlling microbial infections and preventing epidemic diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and potent adjuvant to boost the immune response to the antigen.
Jing-Xing Yang +6 more
semanticscholar +1 more source
Accelerating Vaccine Adjuvant Screening: Early Follicular Dendritic Cell and Germinal Center B Cell Biomarkers Predict Protective Efficacy. [PDF]
Vaccines (Basel)Zhong Y +6 more
europepmc +3 more sources
Cancer Vaccines, Adjuvants, and Delivery Systems
Frontiers in Immunology, 2021 Vaccination was first pioneered in the 18th century by Edward Jenner and eventually led to the development of the smallpox vaccine and subsequently the eradication of smallpox. The impact of vaccination to prevent infectious diseases has been outstanding
S. Paston +3 more
semanticscholar +1 more source
Advances in Infectious Disease Vaccine Adjuvants
Vaccines, 2022 Vaccines are one of the most significant medical interventions in the fight against infectious diseases. Since their discovery by Edward Jenner in 1796, vaccines have reduced the worldwide transmission to eradication levels of infectious diseases ...
Jingyi Fan +5 more
semanticscholar +1 more source
Vaccine adjuvants to engage the cross-presentation pathway
Frontiers in Immunology, 2022 Adjuvants are indispensable components of vaccines for stimulating optimal immune responses to non-replicating, inactivated and subunit antigens. Eliciting balanced humoral and T cell-mediated immunity is paramount to defend against diseases caused by ...
Woojong Lee, M. Suresh
semanticscholar +1 more source
The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models. [PDF]
, 2016 Toll-like receptors (TLRs) play an important role in the innate and adaptive immune responses to pathogens, and are the target of new vaccine adjuvants.
Bates, PA +4 more
core +7 more sources
Natural and Synthetic Saponins as Vaccine Adjuvants
Vaccines, 2021 Saponin adjuvants have been extensively studied for their use in veterinary and human vaccines. Among them, QS-21 stands out owing to its unique profile of immunostimulating activity, inducing a balanced Th1/Th2 immunity, which is valuable to a broad ...
Pengfei Wang
semanticscholar +1 more source