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Delivery of biologics: Topical administration
Biomaterials, 2023 Biologics are unaffordable to a large majority of the global population because of prohibitively expensive fermentation systems, purification and the requirement for cold chain for storage and transportation. Limitations of current production and delivery systems of biologics were evident during the recent pandemic when 90% are delivered using invasive
Rachel J. Kulchar +5 more
openaire +3 more sources
Pharmaceuticals, 2022 Xerostomia is linked to an increased risk of dental caries, oral fungal infections, and speaking/swallowing difficulties, factors that may significantly degrade patients’ life, socially- or emotionally-wise.
Afroditi Kapourani +2 more
doaj +2 more sources
Systemic and topical administration of spermidine accelerates skin wound healing
Cell Communication and Signaling, 2021 Background The skin wound healing process is regulated by various cytokines, chemokines, and growth factors. Recent reports have demonstrated that spermine/spermidine (SPD) promote wound healing through urokinase-type plasminogen activator (uPA)/uPA ...
Daisuke Ito +5 more
doaj +2 more sources
Plasma pharmacokinetics of tigolaner, emodepside, and praziquantel following topical administration of a combination product (Felpreva®) and of intravenous administration of the individual active ingredients in cats [PDF]
Current Research in Parasitology and Vector-Borne Diseases, 2023 Felpreva® for cats contains the new acaricidal/insecticidal active ingredient tigolaner in a fixed combination with the nematocidal and cestocidal compounds emodepside and praziquantel, respectively.
Norbert Mencke +5 more
doaj +3 more sources
Transdermal and Topical Drug Administration in the Treatment of Pain [PDF]
Molecules, 2018 The comprehensive treatment of pain is multidimodal, with pharmacotherapy playing a key role. An effective therapy for pain depends on the intensity and type of pain, the patients’ age, comorbidities, and appropriate choice of analgesic, its dose and route of administration.
Wojciech Leppert +3 more
openaire +5 more sources
Central Serous Chorioretinopathy in a 14-year-old atopic boy: a case report [PDF]
Italian Journal of Pediatrics, 2023 Background Corticosteroids are widely used in medicine. Few cases of central serous chorioretinopathy (CSC) have been reported following topical corticosteroid administration.
Stefano Ranno +5 more
doaj +2 more sources
Scientifica, 2022 This research aimed to determine the topical administration effect of the combination of Sargassum duplicatum and Garcinia mangostana extracts to ameliorate diabetic open wound healing.
Dwi Winarni +10 more
doaj +2 more sources
Lipid vesicular gels for topical administration of antioxidants [PDF]
Colloids and Surfaces B: Biointerfaces, 2022 The application of a formulation on the skin represents an effective way to deliver bio-active molecules for therapeutical purposes. Moreover, the outermost skin layer, the stratum corneum, can be overcome by employing chemical permeation enhancers and edge activators as components.
Carretti, Emiliano
core +5 more sources
BJS Open, 2019 Background Topical administration of tranexamic acid (TXA) reduces bleeding from surgical wounds similarly to intravenous use, but with negligible risk of adverse systemic events. Topical use is expanding, but is off‐label.
T. A. Eikebrokk +5 more
doaj +2 more sources
Graphene oxide topical administration: Skin permeability studies [PDF]
Materials, 2021 Nanostructured carriers have been widely used in pharmaceutical formulations for der-matological treatment. They offer targeted drug delivery, sustained release, improved biostability, and low toxicity, usually presenting advantages over conventional ...
Amaral, SI +9 more
core +6 more sources