Results 111 to 120 of about 423,480 (372)

Long-term Survival and Clinical Benefit from Adoptive T-cell Transfer in Stage IV Melanoma Patients Is Determined by a Four-Parameter Tumor Immune Signature

open access: yesCancer immunology research, 2017
Four parameters were identified—CD8+ TILs, galectin-3+ tumors, galectin-9+ DCs, and a high M1/M2 ratio—whose combined presence was prognostic for long-term survival and predictive for sustained clinical benefit from adoptive T cell transfer in stage IV ...
S. Melief   +10 more
semanticscholar   +1 more source

Differentiation of C2D Macrophage Cells after Adoptive Transfer [PDF]

open access: yesClinical and Vaccine Immunology, 2008
ABSTRACTC2D macrophage cells protect immunocompromised mice from experimentally induced pneumonias after intraperitoneal (i.p.) adoptive transfer. These macrophage cells are immature and display minimal activity in vitro. Therefore, we wanted to understand how adoptive transfer affected these cells.
Laura L. Snyder   +5 more
openaire   +3 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

Lymphoma Immunotherapy: Vaccines, Adoptive Cell Transfer and Immunotransplant [PDF]

open access: yesImmunotherapy, 2009
Therapy for non-Hodgkin lymphoma has benefited greatly from basic science and clinical research such that chemotherapy and monoclonal antibody therapy have changed some lymphoma subtypes from uniformly lethal to curable, but the majority of lymphoma patients remain incurable. Novel therapies with less toxicity and more specific targeting of tumor cells
Joshua Brody, Ronald Levy
openaire   +3 more sources

Matrigel inhibits elongation and drives endoderm differentiation in aggregates of mouse embryonic stem cells

open access: yesFEBS Open Bio, EarlyView.
Stem cell‐based embryo models (SCBEMs) are valuable to study early developmental milestones. Matrigel, a basement membrane matrix, is a critical substrate used in various SCBEM protocols, but its role in driving stem cell lineage commitment is not clearly defined.
Atoosa Amel   +3 more
wiley   +1 more source

Active Immunotherapy and Adoptive Cell Transfer as an Effective Cancer Treatment [PDF]

open access: yes, 2015
There are many ways to fight cancer using the body’s own immune system. Some methods include the administration of vaccines while others involve stimulatory factors injected near tumors. One promising method is enlisting the help of T cells.
Cynamon, Philip Jay
core   +1 more source

Gene Therapy for Pediatric Cancer: State of the Art and Future Perspectives [PDF]

open access: yes, 2003
While modern treatments have led to a dramatic improvement in survival for pediatric malignancy, toxicities are high and a significant proportion of patients remain resistant.
Biagi, Ettore   +3 more
core   +5 more sources

Anti-Tumor Effects after Adoptive Transfer of IL-12 Transposon-Modified Murine Splenocytes in the OT-I-Melanoma Mouse Model. [PDF]

open access: yesPLoS ONE, 2015
Adoptive transfer of gene modified T cells provides possible immunotherapy for patients with cancers refractory to other treatments. We have previously used the non-viral piggyBac transposon system to gene modify human T cells for potential immunotherapy.
Daniel L Galvan   +6 more
doaj   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

open access: yesFEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna   +4 more
wiley   +1 more source

Proliferation-linked apoptosis of adoptively transferred T cells after IL-15 administration in macaques. [PDF]

open access: yesPLoS ONE, 2013
The adoptive transfer of antigen-specific effector T cells is being used to treat human infections and malignancy. T cell persistence is a prerequisite for therapeutic efficacy, but reliably establishing a high-level and durable T cell response by ...
Carolina Berger   +5 more
doaj   +1 more source

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