Results 51 to 60 of about 60,986 (304)
Reenergized Adoptive Cell Transfer Immunotherapy
The FASEB Journal, 2018 Immunotherapy, in treating solid tumors, has seen increased efficacy due to the development of novel strategies of implementation. One innovative strategy, in development by Dr. Weiguo Cui and his colleagues, combines adoptive cell transfer (ACT) with pathogen‐based vaccine techniques in what is called Reenergized ACT (ReACT).
Keith Klestinski +7 more
openaire +1 more source
OncoImmunology, 2013 Adoptive cell transfer (ACT) represents a prominent form of immunotherapy against malignant diseases. ACT is conceptually distinct from dendritic cell-based approaches (which de facto constitute cellular vaccines) and allogeneic transplantation (which can be employed for the therapy of hematopoietic tumors) as it involves the isolation of autologous ...
Erika Vacchelli +7 more
openaire +3 more sources
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
Frontiers in Immunology, 2018 CPT-11 is a first-line chemotherapeutic agent for the treatment of colorectal cancer in clinic. Previous studies including ours have demonstrated that CPT-11 is, however, toxic to the intestinal epithelium and resident peritoneal macrophages.
Wen-Jing Bai +8 more
doaj +1 more source
FEBS Letters, EarlyView.Tuberculosis remains a global health challenge and new therapeutic targets are required. Here, we characterized SseA, a sulfurtransferase from Mycobacterium tuberculosis involved in macrophage infection, and its interaction with the newly identified protein SufEMtb that activates SseA enzymatic activity.
Giulia Di Napoli +10 more
wiley +1 more source
iScience, 2020 Summary: The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent stem cells (PSCs), i.e., PSC-CTLs, have the ability to suppress hepatitis B virus (HBV) infection. After adoptive transfer, PSC-CTLs can infiltrate into
Mohammad Haque +10 more
doaj
Prospects for combined use of oncolytic viruses and CAR T-cells
Journal for ImmunoTherapy of Cancer, 2017 With the approval of talimogene laherparepvec (T-VEC) for inoperable locally advanced or metastatic malignant melanoma in the USA and Europe, oncolytic virotherapy is now emerging as a viable therapeutic option for cancer patients. In parallel, following
Adam Ajina, John Maher
doaj +1 more source
PLoS ONE, 2020 We previously have reported that neonatal Bacillus Calmette-Guerin (BCG) vaccination improves neurogenesis and behavior in early life through affecting the neuroimmune milieu in the brain, but it is uncertain whether activation phenotypes and functional ...
Dan Song +5 more
doaj +1 more source
Adoptive cell transfer as personalized immunotherapy for human cancer. [PDF]
Science, 2015 Adoptive cell therapy (ACT) is a highly personalized cancer therapy that involves administration to the cancer-bearing host of immune cells with direct anticancer activity. ACT using naturally occurring tumor-reactive lymphocytes has mediated durable, complete regressions in patients with melanoma, probably by targeting somatic mutations exclusive to ...
Rosenberg SA, Restifo NP.
europepmc +5 more sources
Toxicities Associated With Adoptive T-Cell Transfer for Cancer [PDF]
The Cancer Journal, 2015 This review describes the toxicities associated with the therapeutic administration of cultured immune cells for the treatment of cancer by review of the literature. The toxicities seen are of 4 types: infection associated with preparative host immunosuppression with chemotherapy prior to cell administration, acute cytokine release by the infused cells,
openaire +3 more sources