Results 51 to 60 of about 377,496 (294)

Adoptive immune transfer from donors offers Anti-HBV protection to HBsAb-negative patients after Allo-HSCT

iScience, 2023
Summary: Adoptive transfer of hepatitis B virus (HBV) immunity may occur following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we investigated the adoptive transfer of HBV immunity in 112 patients without HBV surface antibody ...
Jinhua Ren, QiaoXian Lin, Qi Chen, Jingjing Xu, Dabin Chen, Renli Chen, Kangni Lin, Haojie Zhu, Chenjing Ye, Xiaofeng Luo, Shaozhen Chen, Hui Kong, Qiong Lin, Nan Li, Xu Lin, Zhizhe Chen, Jianda Hu, Ting Yang   +17 more
doaj  

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Prolonged Deleterious Influences of Chemotherapeutic Agent CPT-11 on Resident Peritoneal Macrophages and B1 Cells

Frontiers in Immunology, 2018
CPT-11 is a first-line chemotherapeutic agent for the treatment of colorectal cancer in clinic. Previous studies including ours have demonstrated that CPT-11 is, however, toxic to the intestinal epithelium and resident peritoneal macrophages.
Wen-Jing Bai, Chen-Guang Li, Cheng-Cheng Zhang, Li-Hui Xu, Qiong-Zhen Zeng, Bo Hu, Zhou Hong, Xian-Hui He, Dong-Yun Ouyang   +8 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HBV Replication through Production of IFN-γ and TNF-⍺

iScience, 2020
Summary: The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent stem cells (PSCs), i.e., PSC-CTLs, have the ability to suppress hepatitis B virus (HBV) infection. After adoptive transfer, PSC-CTLs can infiltrate into
Mohammad Haque, Fengyang Lei, Xiaofang Xiong, Yijie Ren, Anil Kumar, Jugal Kishore Das, Xingcong Ren, Deyu Fang, Paul de Figueiredo, Jin-Ming Yang, Jianxun Song   +10 more
doaj  

Prospects for combined use of oncolytic viruses and CAR T-cells

Journal for ImmunoTherapy of Cancer, 2017
With the approval of talimogene laherparepvec (T-VEC) for inoperable locally advanced or metastatic malignant melanoma in the USA and Europe, oncolytic virotherapy is now emerging as a viable therapeutic option for cancer patients. In parallel, following
Adam Ajina, John Maher
doaj   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

Science, 2020
Stem-like T cells mediate response Adoptive cell transfer (ACT) is a type of immunotherapy that uses a patient's own T lymphocytes to recognize and attack cancer.
S. Krishna, Frank J. Lowery, Amy R. Copeland, Erol Bahadiroglu, Ratnadeep Mukherjee, Li Jia, J. Anibal, Abraham Sachs, Serifat Adebola, Devikala Gurusamy, Zhiya Yu, Victoria K. Hill, J. Gartner, Yong F Li, M. Parkhurst, B. Paria, P. Kvistborg, Michael C. Kelly, Stephanie L. Goff, G. Altan-Bonnet, P. Robbins, S. Rosenberg   +21 more
semanticscholar   +1 more source

Adoptive Immunotherapy Based on Chain-Centric TCRs in Treatment of Infectious Diseases

iScience, 2020
Summary: Complications after vaccination, lack of vaccines against certain infections, and the emergence of antibiotic-resistant microorganisms point to the need for alternative ways of protection and treatment of infectious diseases. Here, we proposed a
Anastasiia A. Kalinina, Ludmila N. Nesterenko, Alexandra V. Bruter, Denis V. Balunets, Dmitriy M. Chudakov, Mark Izraelson, Olga V. Britanova, Ludmila M. Khromykh, Dmitry B. Kazansky   +8 more
doaj  

The adoptive transfer of BCG-induced T lymphocytes contributes to hippocampal cell proliferation and tempers anxiety-like behavior in immune deficient mice.

PLoS ONE, 2020
We previously have reported that neonatal Bacillus Calmette-Guerin (BCG) vaccination improves neurogenesis and behavior in early life through affecting the neuroimmune milieu in the brain, but it is uncertain whether activation phenotypes and functional ...
Dan Song, Fangfang Qi, ShuaiShuai Liu, Zhongsheng Tang, Jinhai Duan, Zhibin Yao   +5 more
doaj   +1 more source