Results 11 to 20 of about 40,918 (202)

General ADP-Ribosylation Mechanism Based on the Structure of ADP-Ribosyltransferase–Substrate Complexes [PDF]

Toxins
ADP-ribosylation is a ubiquitous modification of proteins and other targets, such as nucleic acids, that regulates various cellular functions in all kingdoms of life.
Hideaki Tsuge, Noriyuki Habuka, Toru Yoshida   +2 more
doaj   +2 more sources

Poly ADP-Ribosylation in a Plant Pathogenic Oomycete Phytophthora infestans: A Key Controller of Growth and Host Plant Colonisation [PDF]

Journal of Fungi
ADP-ribosylation is a reversible modification of proteins and nucleic acids, which controls major cellular processes, including DNA damage repair, cell proliferation and differentiation, metabolism, stress, and immunity in plants and animals.
Viktoriya O. Samarskaya, Sofya Koblova, Tatiana Suprunova, Eugene A. Rogozhin, Nadezhda Spechenkova, Sofiya Yakunina, Andrew J. Love, Natalia O. Kalinina, Michael Taliansky   +8 more
doaj   +2 more sources

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation [PDF]

The EMBO Journal
PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods.
Pulak Kar, Chatrin Chatrin, Nina Đukić, Osamu Suyari, Marion Schuller, Kang Zhu, Evgeniia Prokhorova, Nicolas Bigot, Domagoj Baretić, Juraj Ahel, Jonas Damgaard Elsborg, Michael L Nielsen, Tim Clausen, Sébastien Huet, Mario Niepel, Sumana Sanyal, Dragana Ahel, Rebecca Smith, Ivan Ahel   +18 more
doaj   +2 more sources

ADP-Ribosylation in Antiviral Innate Immune Response

Pathogens, 2023
Adenosine diphosphate (ADP)-ribosylation is a reversible post-translational modification catalyzed by ADP-ribosyltransferases (ARTs). ARTs transfer one or more ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to the target substrate and release ...
Qian Du, Ying Miao, Wei He, Hui Zheng
doaj   +1 more source

Functional roles of ADP-ribosylation writers, readers and erasers

Frontiers in Cell and Developmental Biology, 2022
ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the dynamic interplay between its writers, readers and erasers.
Ping Li, Yushuang Lei, Jia Qi, Wanqin Liu, Kai Yao   +4 more
doaj   +1 more source

Characterization of an Aedes ADP-Ribosylation Protein Domain and Role of Post-Translational Modification during Chikungunya Virus Infection

Pathogens, 2023
Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which ...
Ramesh Kumar, Divya Mehta, Debasis Nayak, Sujatha Sunil   +3 more
doaj   +1 more source

Nucleoplasmic Lamin A/C controls replication fork restart upon stress by modulating local H3K9me3 and ADP-ribosylation levels. [PDF]

Nat Commun
Cherdyntseva V, Paulson J, González-Acosta D, Ubieto-Capella P, Rodrigues M, Aouami M, Adakli S, Gagné JP, Bakker C, Poirier GG, Taneja N, Lopes M.   +11 more
europepmc   +3 more sources

Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight

Cells, 2021
Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD+)-dependent post-translational modification that is found on proteins as well as on nucleic acids.
Ann-Katrin Hopp, Michael O. Hottiger
doaj   +1 more source

Temporal and Site-Specific ADP-Ribosylation Dynamics upon Different Genotoxic Stresses

Cells, 2021
The DNA damage response revolves around transmission of information via post-translational modifications, including reversible protein ADP-ribosylation.
Sara C. Buch-Larsen, Alexandra K. L. F. S. Rebak, Ivo A. Hendriks, Michael L. Nielsen   +3 more
doaj   +1 more source

MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast transdifferentiation

iScience, 2021
Summary: While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation of fibroblasts to myoblasts promotes
Lavinia Bisceglie, Ann-Katrin Hopp, Kapila Gunasekera, Roni H. Wright, François Le Dily, Enrique Vidal, Alessandra Dall’Agnese, Luca Caputo, Chiara Nicoletti, Pier Lorenzo Puri, Miguel Beato, Michael O. Hottiger   +11 more
doaj   +1 more source