Results 21 to 30 of about 188,515 (292)
eLife, 2017 The modification of serines by molecules of ADP-ribose plays an important role in signaling that the DNA in a cell has been damaged and needs to be repaired.
Giuliana Katharina Moeller +1 more
doaj +3 more sources
Control of replication and gene expression by ADP-ribosylation of DNA in Mycobacterium tuberculosis [PDF]
The EMBO JournalMycobacterium tuberculosis maintains long-term infections characterised by the need to regulate growth and adapt to contrasting in vivo environments. Here we show that M.
Rachel E Butler +9 more
doaj +2 more sources
ADP-ribosylation of NuMA promotes DNA single-strand break repair and transcription
Cell ReportsSummary: Single-strand breaks (SSBs) are prevalent DNA lesions implicated in genome instability. The nuclear mitotic apparatus protein (NuMA) has been reported to promote SSB repair (SSBR) and regulate transcription following oxidative stress.
Arwa A. Abugable +4 more
doaj +2 more sources
ADP-ribosylation of DNA and RNA
DNA Repair, 2021 ADP-ribosylation is a chemical modification of macromolecules found across all domains of life and known to regulate a variety of cellular processes. Notably, it has a well-established role in the DNA damage response. While it was historically known as a
Joséphine Groslambert +2 more
semanticscholar +3 more sources
PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
The EMBO JournalPARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods.
Pulak Kar +18 more
doaj +2 more sources
Emerging roles of eraser enzymes in the dynamic control of protein ADP-ribosylation
Nature Communications, 2019 ADP-ribose erasing enzymes are increasingly recognized as critical regulators of protein ADP-ribosylation dynamics in living systems. Here, the authors review recent advances in the discovery and characterization of ADP-ribose erasers and discuss their ...
Julia O’Sullivan +6 more
doaj +2 more sources
Reversible ADP-ribosylation of RNA [PDF]
Nucleic Acids Research, 2019 ADP-ribosylation is a reversible chemical modification catalysed by ADP-ribosyltransferases such as PARPs that utilize nicotinamide adenine dinucleotide (NAD+) as a cofactor to transfer monomer or polymers of ADP-ribose nucleotide onto macromolecular ...
D. Munnur +7 more
semanticscholar +4 more sources
Poly-ADP-ribosylation modulated by poly(ADP-ribose) polymerase 1 is associated with glucose metabolism in colorectal cancer cells. [PDF]
Transl OncolZhang C +5 more
europepmc +2 more sources
Specificity of DNA ADP-Ribosylation Reversal by NADARs [PDF]
ToxinsRecent discoveries establish DNA and RNA as bona fide substrates for ADP-ribosylation. NADAR (“NAD- and ADP-ribose”-associated) enzymes reverse guanine ADP-ribosylation and serve as antitoxins in the DarT-NADAR operon.
Bara Cihlova +4 more
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ADP-ribosylation of arginine [PDF]
Amino Acids, 2010 Arginine adenosine-5'-diphosphoribosylation (ADP-ribosylation) is an enzyme-catalyzed, potentially reversible posttranslational modification, in which the ADP-ribose moiety is transferred from NAD(+) to the guanidino moiety of arginine. At 540 Da, ADP-ribose has the size of approximately five amino acid residues.
Sabrina Laing +3 more
core +3 more sources