Results 101 to 110 of about 3,569 (120)
Some of the next articles are maybe not open access.
Journal of Theoretical Biology, 1993
A model for eukaryotic DNA damage repair is proposed in which poly(ADP-ribose) polymerase(NAD+ ADP-ribosyl transferase, EC 2,4,2,30) plays an important role. In this model, poly(ADP-ribose) polymerase regulates transcription of genes that are induced by DNA-damaging agents.
openaire +2 more sources
A model for eukaryotic DNA damage repair is proposed in which poly(ADP-ribose) polymerase(NAD+ ADP-ribosyl transferase, EC 2,4,2,30) plays an important role. In this model, poly(ADP-ribose) polymerase regulates transcription of genes that are induced by DNA-damaging agents.
openaire +2 more sources
Molecular Carcinogenesis, 1999
The aim of this work was to study the role of the tumor suppressor p53 and of poly(ADP-ribose) transferase (pADPRT) in the control of hepatocyte apoptosis in two different in vivo models, i.e., during the process of tumor initiation by the genotoxin and cytotoxin N-nitrosomorpholine (NNM) and after withdrawal of the hepatomitogen cyproterone acetate ...
J, Weşierska-Gadek +3 more
openaire +2 more sources
The aim of this work was to study the role of the tumor suppressor p53 and of poly(ADP-ribose) transferase (pADPRT) in the control of hepatocyte apoptosis in two different in vivo models, i.e., during the process of tumor initiation by the genotoxin and cytotoxin N-nitrosomorpholine (NNM) and after withdrawal of the hepatomitogen cyproterone acetate ...
J, Weşierska-Gadek +3 more
openaire +2 more sources
1992
Despite the increasing interest on both the physiological and pathological role of ADP-ribosylation reactions, little appears to be known about the mechanism by which the intracellular level of NAD+ is regulated with respect to its participation in the redox metabolism on the one hand and to its utilization in poly(ADP-ribosy)lation on the other ...
N. Raffaelli +6 more
openaire +1 more source
Despite the increasing interest on both the physiological and pathological role of ADP-ribosylation reactions, little appears to be known about the mechanism by which the intracellular level of NAD+ is regulated with respect to its participation in the redox metabolism on the one hand and to its utilization in poly(ADP-ribosy)lation on the other ...
N. Raffaelli +6 more
openaire +1 more source
Regulation of poly(ADP-ribose) transferase activity by 2',5'-oligoadenylates.
Biochemistry international, 1984pppA2'pA2'pA appears to be a potent natural noncompetitive inhibitor of poly (ADP-ribose) transferase activity in the histone dependent reaction of ADP-ribosylation with Ki=5 microM. Moreover, it is a noncompetitive inhibitor of the Mg2+ dependent reaction of autoADPRT-ribosylation with Ki=20 microM.
A D, Pivazian +6 more
openaire +1 more source
Loss of Poly(ADP-Ribose) Transferase Activity in Liver of Rats Treated with 2-Acetylaminofluorene
1989The chronic exposure of rats to a feeding regimen containing subcarcinogenic doses of N-2-acetylaminofluorene (2AAF) induces, in liver, multiple effects and the progression to hepatocellular carcinoma(s) (1). Among the effects induced at the hepatocellular level, which seem to play a crucial role in the initial steps of the carcinogenic process, are ...
C. F. Cesarone +5 more
openaire +1 more source
Biochemical and Biophysical Research Communications, 1984
Rats fed a synthetic diet containing 0.25% benzamide, 0.1% phenobarbital, separately or in combination, for two weeks showed a significant augmentation in the activity of nuclear poly(ADP-ribose) polymerase as well as changes in various nuclear, microsomal and cytosolic liver enzymes involved in the metabolism of xenobiotics.
M J, Griffin +5 more
openaire +2 more sources
Rats fed a synthetic diet containing 0.25% benzamide, 0.1% phenobarbital, separately or in combination, for two weeks showed a significant augmentation in the activity of nuclear poly(ADP-ribose) polymerase as well as changes in various nuclear, microsomal and cytosolic liver enzymes involved in the metabolism of xenobiotics.
M J, Griffin +5 more
openaire +2 more sources
2003
Some images did not scan well. Please consult original document. ; The glycophosphatidylinositol(GPI)-linked membrane protein ART2 is an antigenic determinant for T lymphocytes that regulate the expression of diabetes in the BB/W rat model. Though little is understood of the physiologic role of ART2 on T lymphocytes, ART2 is a member of the mono-ADP ...
openaire +2 more sources
Some images did not scan well. Please consult original document. ; The glycophosphatidylinositol(GPI)-linked membrane protein ART2 is an antigenic determinant for T lymphocytes that regulate the expression of diabetes in the BB/W rat model. Though little is understood of the physiologic role of ART2 on T lymphocytes, ART2 is a member of the mono-ADP ...
openaire +2 more sources
1989
Polymerization of ADP-ribose from NAD+ by poly(ADP-ribose) transferase is initiated by auto-mono-ADP-ribosylation of the enzyme followed by ADP-ribose transfer to other acceptor proteins and subsequent elongation (1). DNA is required as a coenzyme, and an enzyme-associated DNA, defined as sDNA (2), can be isolated which is more efficient than crude ...
Alaeddin Hakam +3 more
openaire +1 more source
Polymerization of ADP-ribose from NAD+ by poly(ADP-ribose) transferase is initiated by auto-mono-ADP-ribosylation of the enzyme followed by ADP-ribose transfer to other acceptor proteins and subsequent elongation (1). DNA is required as a coenzyme, and an enzyme-associated DNA, defined as sDNA (2), can be isolated which is more efficient than crude ...
Alaeddin Hakam +3 more
openaire +1 more source
Analogues of benzamide containing a sulfur atom as poly(ADP-ribose) transferase inhibitors.
Biochemistry international, 1987Structural analogues of benzamide (BA) containing a sulfur atom were tested for their ability to inhibit the enzyme poly(ADP-ribose)transferase (ADPRT) in cultured Chinese Hamster Ovary (CHO) cells. These compounds were benzene sulfonamide (BSA), thiobenzamide (TB) and 3-thiophene carboxamide (TCA) and their activity was compared with that of benzamide
CANTONI, ORAZIO +5 more
openaire +2 more sources
1989
The molecular mechanism of poly(ADP-ribose) transferase activation following the treatment of mammalian cells with DNA damaging agents is still unknown. Several lines of evidence indicate that the activation process does not require de novo synthesis of the enzyme and that the extent of increase in activity is correlated to the type of DNA damage (1 ...
A. I. Scovassi +4 more
openaire +1 more source
The molecular mechanism of poly(ADP-ribose) transferase activation following the treatment of mammalian cells with DNA damaging agents is still unknown. Several lines of evidence indicate that the activation process does not require de novo synthesis of the enzyme and that the extent of increase in activity is correlated to the type of DNA damage (1 ...
A. I. Scovassi +4 more
openaire +1 more source