Results 81 to 90 of about 131,760 (358)

Dkk3 is a component of the genetic circuitry regulating aldosterone biosynthesis in the adrenal cortex.

open access: yesHuman Molecular Genetics, 2012
Primary aldosteronism (PA, autonomous aldosterone production from the adrenal cortex) causes the most common form of secondary arterial hypertension (HT), which is also the most common curable form of HT. Recent studies have highlighted an important role
A. El Wakil   +9 more
semanticscholar   +1 more source

Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions

open access: yesThe Journal of Pathology, EarlyView.
Abstract High‐risk neuroblastomas exhibit a high degree of intratumoral heterogeneity. Single‐cell RNA sequencing has greatly improved our understanding of these tumors, but the method lacks cellular tissue context and spatial information about local signaling dynamics.
Joachim T Siaw   +10 more
wiley   +1 more source

Biochemical mechanism of the o,p’-DDD effect on the adrenal cortex [PDF]

open access: yesThe Ukrainian Biochemical Journal, 2017
o,p’-Dichlorodiphenyldichloroethane (o,p’-DDD, mitotane) is used in the treatment of adrenocortical cancer and Cushing’s disease. This medicine induces numerous biochemical changes in the adrenal cortex, as well as disorder in the mitochondrial structure.
A. S. Mikosha, O. I. Kovzun
doaj   +1 more source

Adrenal Aging and Its Implications on Stress Responsiveness in Humans

open access: yesFrontiers in Endocrinology, 2019
Normal aging results in subtle changes both in ACTH and cortisol secretion. Most notable is the general increase in mean daily serum cortisol levels in the elderly, without a noteworthy alteration in the normal circadian rhythm pattern.
Andreas Yiallouris   +6 more
semanticscholar   +1 more source

Comprehensive Review of the Impact of Maternal Stress on Fetal Development

open access: yesPediatric Discovery, EarlyView.
ABSTRACT Maternal stress impacts millions of pregnant women across the globe each year and refers to mental or psychological stress that occurs during the prenatal period. Although it remains known that maternal stress can negatively impact maternal health, the downstream effects of stress on fetal and infant development in the long‐term are unclear ...
Divya Tadanki   +8 more
wiley   +1 more source

Qué sabemos sobre las consecuencias a largo plazo de la separación materna temprana y la respuesta neuroendocrina al estrés [PDF]

open access: yes, 2014
Adverse conditions during early life are a risk factor for stress-related diseases. How this early adversity induce long-term effects is not well understood, however there are several evidence that the stress hormones play a determining role.
Renard, Georgina Maria   +1 more
core  

Ultradian, circadian and seasonal rhythms in cortisol secretion and adrenal responsiveness to ACTH and yarding in unrestrained red deer (Cervus elaphus) stags [PDF]

open access: yes, 1999
Seasonal changes in the activity and responsiveness of the adrenal gland in red deer (Cervus elaphus) stags were quantified by measuring 24 h endogenous cortisol secretory profiles and plasma cortisol responses to either administration of exogenous ACTH ...
Crockford, J.N.   +2 more
core   +2 more sources

Androgen deficiency in women with adrenal insufficiency. Dehydroepiandrosterone. Review [PDF]

open access: yesГинекология, 2018
It is known that adrenal insufficiency (AI) is a severe life-threatening disease due to the exceptional role of glucocorticoids and mineralocorticoids in the human body. At the same time, according to some reports, the deficit of androgens synthesized by
N F Nuralieva   +3 more
doaj   +1 more source

Expression and Function of Endocannabinoid Receptors in the Human Adrenal Cortex

open access: yesHormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, 2009
Endogenous cannabinoids are important signaling molecules in neuroendocrine control of homeostatic and reproductive functions including stress response and energy metabolism.
C. G. Ziegler   +6 more
semanticscholar   +1 more source

Nose‐to‐Brain Delivery of Acyl‐Ghrelin Peptide Gold Nanoconjugates for Treatment of Neurodegenerative Diseases

open access: yesSmall, EarlyView.
Intranasal delivery of acyl‐ghrelin using gold nanorods (AuNRs) is investigated as a strategy for treating neurodegenerative diseases. Acyl‐ghrelin is conjugated to AuNRs under optimized conditions that preserve its bioactivity and prevent nanoparticle cross‐linking.
Shunping Han   +6 more
wiley   +1 more source

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