Results 161 to 170 of about 46,059 (254)

Clinical application of single‐cell RNA sequencing in disease and therapy

Clinical and Translational Medicine, Volume 15, Issue 11, November 2025.
This review provides a comprehensive overview of the application of scRNA‐seq in revisiting the somatic cell evolutions in human diseases, as well as in biomarker discovery and drug development. Abstract Background The emergence of single‐cell RNA sequencing (scRNA‐seq) technology has revolutionized our capacity to study cell functions in complex ...
Aisha Shigna Nadukkandy, Sowmiya Kalaiselvan, Lin Lin, Yonglun Luo   +3 more
wiley   +1 more source

Inhibitory effects of the alpha-2 adrenergic agonists clonidine and dexmedetomidine on enhanced airway tone in ovalbumin-sensitized guinea pigs

, 2007
Michiaki Yamakage, Soshi Iwasaki, J. Satoh, A Namiki   +3 more
openalex   +1 more source

Lower Urinary Tract Symptoms in Male Patients With Multiple Sclerosis: Prevalence and Associations With Quality of Life, Depression, and Anxiety

Neurourology and Urodynamics, Volume 44, Issue 8, Page 1553-1559, November 2025.
ABSTRACT Purpose Lower urinary tract symptoms (LUTS) are frequent in male patients with multiple sclerosis (MS). This study was planned to investigate the frequency and distress of LUTS in men with MS and their association with quality of life (QoL), depression, and anxiety. Methods One hundred male patients with MS were included in the study.
Yesim Akkoc, Bedriye Karaman, Asli Koskderelioglu, Ozgul Ekmekci, Neslihan Eskut, Nur Yuceyar   +5 more
wiley   +1 more source

Endothelium-dependent NO-mediated vasodilation in humans is attenuated by peripheral a1-adrenoceptor activation

Vascular Health and Risk Management, 2005
Adriaan M Kamper, Anton JM de Craen, Rudi GJ Westendorp, Gerard J BlauwDepartments of Gerontology & Geriatrics, Leiden University Medical Center, Leiden, The NetherlandsObjectives: The release of nitric oxide is controlled by cholinergic and ...
Adriaan M Kamper, Anton JM de Craen, Rudi GJ Westendorp, Gerard J Blauw   +3 more
doaj  

Effect of anticholinergic eye drops on intraorbital, periorbital and brain pulsation power

Acta Ophthalmologica, Volume 103, Issue 7, Page e511-e523, November 2025.
Abstract Purpose The study aims to investigate the effect of pharmacologically reducing parasympathetic activity on ocular and cerebral pulsations, inspired by recent discoveries of a glymphatic‐like system in the eye driven by physiological pulsations.
Seyed Mohsen Ebrahimi, Niko Huotari, Ville Saarela, Marja Honkamo, Lauri Raitamaa, Vesa Korhonen, Johanna Tuunanen, Janne Kananen, Vesa Kiviniemi   +8 more
wiley   +1 more source

Brachial plexus block with bupivacaine: effects of added alpha-adrenergic agonists: comparison between clonidine and epinephrine [PDF]

, 1991
J.J. Eledjam, J Deschodt, Éric Viel, Jean F. Lubrano, Pierre Charavel, F. d′Athis, J. du Cailar   +6 more
openalex   +1 more source

Selatogrel: Potential to redefine timely anti‐platelet intervention

British Journal of Pharmacology, Volume 182, Issue 22, Page 5435-5452, November 2025.
Acute coronary syndrome (ACS) encompasses a number of heart diseases that cause a sudden decrease in coronary perfusion, precipitating cardiomyocyte necrosis or heightened risk thereof. This pathology is a major burden of cardiovascular disease.
Rudy N. Zalzal, Peter P. Salem, Ali H. Dakroub, Ali H. Eid   +3 more
wiley   +1 more source

Identification of Alpha-Adrenergic Agonists as Potential Therapeutic Agents for Dermatomyositis through Drug-Repurposing Using Public Expression Datasets

, 2016
Hyunje Grace Cho, David Fiorentino, Matthew A. Lewis, Marina Sirota, Kavita Y. Sarin   +4 more
openalex   +1 more source

Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene. [PDF]

, 1990
Klaus Seuwen, I Magnaldo, Brian K. Kobilka, Marc G. Caron, John W. Regan, Robert J. Lefkowitz, Jacques Pouysségur   +6 more
openalex   +1 more source

Dobutamine improves haemodynamics and oxygen delivery in standing and isoflurane‐anaesthetised horses

Equine Veterinary Journal, Volume 57, Issue 6, Page 1677-1689, November 2025.
Abstract Background Dobutamine is a first‐line therapy for hypotension in anaesthetised horses, but the effects on haemodynamic parameters in standing and anaesthetised horses are not well studied. Objectives To investigate the effects of dobutamine in escalating dosages on haemodynamic performance in awake and anaesthetised horses.
Emma B. Gorenberg, JoAnn Slack, Darko Stefanovski, DeAnna Theiss, Klaus Hopster   +4 more
wiley   +1 more source