Results 171 to 180 of about 984,866 (243)

Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder. [PDF]

Front Mol Neurosci
Yamamuro K, Yamauchi T, Makinodan M.
europepmc   +1 more source

G Protein‐Coupled Receptor in High‐Altitude Diseases: Mechanistic Insights and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
High‐altitude hypobaric hypoxia activates multiorgan GPCR signaling networks that regulate ventilatory responses, cerebral endothelial barrier integrity, erythropoiesis and red blood cell metabolism, pulmonary vascular remodeling, and cardiac adaptation. Dysregulated GPCR pathways contribute to acute and chronic high‐altitude diseases, while clinically
Qing Zhao, Changliang Liu, Lu Dai, Kun Zheng, Kun Liang, Chuanling Pan, Lianhua Liu, Ling Chen, Xuefei He, Hui Yan, Lei Chen, Huaping Zheng, Cheng Deng, Fengming Luo   +13 more
wiley   +1 more source

Three Adult Cases of ADHD With Comorbid Tic Symptoms Successfully Treated With Guanfacine Monotherapy. [PDF]

Neuropsychopharmacol Rep
Tada K, Tada T, Tsuboi T, Watanabe K.
europepmc   +1 more source

A comparison of presynaptic inhibition mediated via prostaglandin and adrenergic alpha-agonist in cholinergic transmission of canine small intestine.

Fukushima journal of medical science, 1982
N, Nakahata, H, Nakanishi, T, Suzuki
openaire   +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

Pulmonary Arterial Hypertension Associated With Chronic Mephedrone Use: A Case Report

Pulmonary Circulation, Volume 16, Issue 4, October 2026.
ABSTRACT Mephedrone is a synthetic cathinone with sympathomimetic effects, but has not previously been linked to pulmonary arterial hypertension (PAH). We report a 42‐year‐old woman with no prior cardiopulmonary disease who presented with severe pre‐capillary PAH after a decade of near‐daily mephedrone use.
Masoud Kashoub, Michael Plunkett, Heba Nashat, Konstantinos Dimopoulos, Colm McCabe, Carl Harries, S. John Wort, Paul I. Dargan, Laura C. Price   +8 more
wiley   +1 more source

Receptor-Targeted Antiemetic Strategies in Cats: A Systematic Review and Intervention-Specific Meta-Analysis. [PDF]

Vet Med Sci
Ersöz U, Özkalipci Ç.
europepmc   +1 more source

Intranasal Dexmedetomidine for Paediatric Procedural Sedation in the Emergency Department: A Single‐Centre Retrospective Observational Cohort Study

Emergency Medicine Australasia, Volume 38, Issue 5, October 2026.
ABSTRACT Objectives To describe the use, effectiveness and safety of intranasal dexmedetomidine (IN DEX) for ED paediatric procedural sedation. Method A retrospective cohort study was conducted over 7 months following implementation of an IN DEX guideline at Townsville University Hospital ED.
Emma Whyte, Theophilus I. Emeto, Frances Snowden, Vinay Gangathimmaiah   +3 more
wiley   +1 more source

Liver-nervous system axis in MASLD: mechanistic insights and emerging targeted therapies. [PDF]

eGastroenterology
Wang X, Zhang J, Guo J, Sheng B, Xu J, Yuan Y, Mehal W, Zuo L, Wang H.   +8 more
europepmc   +1 more source

Haloperidol for Hypoactive and Hyperactive Delirium in ICU Patients—A Post Hoc Bayesian Analysis of the AID‐ICU Trial

Acta Anaesthesiologica Scandinavica, Volume 70, Issue 9, October 2026.
ABSTRACT Background Delirium is clinically classified into hypoactive or hyperactive motoric subtypes, which may have different responses to treatment. We assessed heterogeneity in treatment effects according to baseline motoric subtype in the AID‐ICU trial, which randomised adult ICU patients with delirium to haloperidol versus placebo.
Nina C. Andersen‐Ranberg, Lone Musaeus Poulsen, Anders Perner, Johanna Hästbacka, Matthew Morgan, Giuseppe Citerio, Stine Estrup Damby, Camilla Bekker Mortensen, Marie Oxenbøll Collet, Sven‐Olaf Weber, Anne Sofie Andreasen, Morten Bestle, Bülent Uslu, Helle Scharling Pedersen, Louise Gramstrup Nielsen, Kjeld Damgaard, Troels Bek Jensen, Trine Sommer, Nilanjan Dey, Ole Mathiesen, Anders Granholm   +20 more
wiley   +1 more source