Results 91 to 100 of about 91,166 (328)

Antiglycation Activity of Aucubin In Vitro and in Exogenous Methylglyoxal Injected Rats

Molecules, 2019
Advanced glycation end products (AGEs) is a causative factor of various chronic diseases, including chronic kidney disease and atherosclerosis. AGE inhibitors, such as aminoguanidine and pyridoxamine, have the therapeutic activities for reversing the ...
Eunsoo Jung, Su-Bin Park, Woo Kwon Jung, Hyung Rae Kim, Junghyun Kim   +4 more
doaj   +1 more source

Antiaging, Wound‐Healing Properties and Chemical Characterization of Crude Hydroalcoholic Extract and Fractions of Myrcia neoobscura

Chemistry &Biodiversity, EarlyView.
ABSTRACT The aim of this study was to characterize the phytochemical profile and potential antiaging and wound‐healing activities of 70% hydroalcoholic crude extract (CHE) from Myrcia neoobscura leaves and its fractions—insoluble (IF), ethyl acetate (EAF), and aqueous (AF)—for use in phytocosmetics for skin application.
Larissa Mascarenhas Krepsky, Ana Helena Loos Moritz, Mayra Alice Corrêa Pitz, Letícia Bachmann, Diogo Alexandre Siebert, Paula Flegar, Stjepan Lešnjak, Ana Tirić, Amanda Tavares Germano, Mayara da Silva, Carlos Rafael Vaz, Larissa Benvenutti, André Luís de Gasper, José Roberto Santin, Isabel Daufenback Machado, Luciano Vitali, Marijana Zovko Končić, Michele Debiasi Alberton   +17 more
wiley   +1 more source

The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion (alters structural composition)

Endocrinology, Diabetes & Metabolism, 2021
Aims The accumulation of advanced glycation end products is implicated in the development and progression of diabetic kidney disease. No study has examined whether stimulating advanced glycation clearance via receptor manipulation is reno‐protective in ...
Aowen Zhuang, Felicia Y. T. Yap, Danielle J. Borg, Domenica McCarthy, Amelia Fotheringham, Sherman Leung, Sally A. Penfold, Karly C. Sourris, Melinda T. Coughlan, Benjamin L. Schulz, Josephine M. Forbes   +10 more
doaj   +1 more source

Selective disappearance of individuals with high levels of glycated haemoglobin in a free-living bird [PDF]

, 2016
This work was supported by the ANR (ANR-06-JCJC0082 to B.D.), the CNRS (PEPS INEE and PICS France–Switzerland to B.D.), the French Ministe`re de l’Enseignement Supe´rieur et de la Recherche (PhD fellowship to C.R.), the Re´gion Rhoˆne-Alpes (Explora’doc ...
Bize, Pierre, Cauchard, Laure, Doligez, Blandine, Récapet, Charlotte, Sibeaux, Adélaïde   +4 more
core   +2 more sources

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Phenolic Compounds From Myrcia tijucensis: Insights Into Antioxidant and Antidiabetic Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT The genus Myrcia from the Myrtaceae family contains species with therapeutic properties, such as reducing glycemia and oxidative stress. This study investigated the effects of the hydroalcoholic extract of Myrcia tijucensis in an animal model of Type 1 diabetes induced by alloxan.
Nathielli Nayara Pauleti, Brenda Wiggers, Ana Luiza de Moraes G. Boaventura, Ana Carolina Dutra, Luiz Guilherme de Alcantara Grilo, Jan Pereira Wotmeyer, Camila Jeriane Paganelli, Camila Panini, Rafaela Beatriz Cunha, Michele Debiasi Alberton, Luciano Vitali, Gustavo Amadeu Micke, Daniela Delwing‐de Lima, Débora Delwing‐Dal Magro   +13 more
wiley   +1 more source

Role of advanced glycation end products in cellular signaling

Redox Biology, 2014
Improvements in health care and lifestyle have led to an elevated lifespan and increased focus on age-associated diseases, such as neurodegeneration, cardiovascular disease, frailty and arteriosclerosis.
Christiane Ott, Kathleen Jacobs, Elisa Haucke, Anne Navarrete Santos, Tilman Grune, Andreas Simm   +5 more
doaj   +1 more source

Pathological Role of Receptor for Advanced Glycation End Products in Calcified Aortic Valve Stenosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Aortic stenosis (AS) is highly prevalent in patients with atherosclerotic cardiovascular disease. Advanced glycation end products (AGEs) and the receptor for AGEs (RAGE) play a pivotal role for vascular calcification in atherosclerosis.
Kosuke Saku, Nobuhiro Tahara, Tohru Takaseya, Hiroyuki Otsuka, Kazuyoshi Takagi, Takahiro Shojima, Yusuke Shintani, Yasuyuki Zaima, Satoshi Kikusaki, Tomofumi Fukuda, Atsunobu Oryoji, Yuri Nishino, Takanori Matsui, Tatsuyuki Kakuma, Jun Akiba, Yoshihiro Fukumoto, Sho‐ichi Yamagishi, Hiroyuki Tanaka   +17 more
doaj   +1 more source

Advanced glycation end-products in diabetic nephropathy [PDF]

Nephrology Dialysis Transplantation, 1996
Advanced glycation end-products (AGEs) are the pigmented and fluorescent adduct formed by a non-enzymatic reaction between sugar and protein. Since AGEs are generated in high glucose milieu, then induce the structural and functional alteration of matnx proteins, and have biological effects on various kinds of cells including mesangial cells, AGEs have ...
Toshio Miyata, Kenji Maeda, Satoshi Sugiyama, Kaoru Horie, M. Tsuyuki, H. Tanaka, Yoshiyasu Iida   +6 more
openaire   +3 more sources

Identification of Methylglyoxal Reactive Proteins with Photocaged Glycating Agents

ChemBioChem, EarlyView.
Photocaged methylglyoxal (PC‐MGO) derivatives enable studying protein glycation under mild conditions. The active glycating agents can be released in the protein solution by irradiating the sample with UV light. Compared to the earlier reported chemically activated MGO probes, the photocaged probes are more potent.
Saskia Sokoliova, I. Raluca Sardaru, Franciszek P. Warguła, Jos H. Hermans, Hjalmar P. Permentier, Peter L. Horvatovich, Martin D. Witte   +6 more
wiley   +1 more source