Results 41 to 50 of about 8,200,615 (297)

Zinc against advanced glycation end products [PDF]

Clinical and Experimental Pharmacology and Physiology, 2018
SummaryAdvanced glycation end products (AGEs) are destructive compounds with pathogenic importance in age‐related chronic diseases. Zinc has antioxidant, anti‐inflammatory and anti‐apoptotic potential. This study aimed to summarize effects of zinc onAGEformation andAGE‐induced damaging agents.
Sorayya Kheirouri, Mohammad Alizadeh, Vahid Maleki   +2 more
openaire   +2 more sources

Antiglycation potential of commercial available extracts of two Indian medicinal plants: Pterocarpus marsupium and Artocarpus lakoocha using advanced glycation end products (AGE) competitive fluorescence assay

Cogent Food & Agriculture, 2021
Glycation is a non-enzymatic biochemical reaction between reducing sugars and amino acids, causing the crosslinking and rearrangement of glycated proteins, leading to irreversible formation of Advanced Glycation End products (AGEs).
Alpana Pande, Lakshmi Mundkur, Anurag Pande, Sarang Bani, Muhammed Majeed   +4 more
doaj   +1 more source

Advanced glycation end products

, 2022
Advanced glycation end products (AGEs) are a heterogeneous group of compounds formed by non-enzymatic interactions between the carbonyl groups of reducing sugars and free amino groups of proteins, lipids, or nucleic acids.
Dat, Pham Thai
core  

Clinical Value of High Mobility Group Box 1 and the Receptor for Advanced Glycation End-products in Head and Neck Cancer: A Systematic Review

International Archives of Otorhinolaryngology, 2016
Introduction High mobility group box 1 is a versatile protein involved in gene transcription, extracellular signaling, and response to inflammation. Extracellularly, high mobility group box 1 binds to several receptors, notably the receptor for advanced ...
Austin Nguyen, Sheila Bhavsar, Erinn Riley, Gabriel Caponetti, Devendra Agrawal   +4 more
doaj   +1 more source

Magnolol ameliorates the accumulation of reactive oxidative stress and inflammation in diabetic periodontitis

Journal of the Formosan Medical Association, 2021
Background/Purpose: Periodontal disease and diabetes mellitus (DM) are both chronic inflammatory and highly prevalent diseases. A large amount of evidence suggested that the accumulation of oxidative stress plays a significant role in the deterioration ...
Chia-Ming Liu, Szu-Han Chen, Yi-Wen Liao, Chuan-Hang Yu, Cheng-Chia Yu, Pei-Ling Hsieh   +5 more
doaj   +1 more source

Advanced glycation end products and diabetic retinopathy [PDF]

Journal of Ocular Biology, Diseases, and Informatics, 2012
Studies have established hyperglycemia as the most important factor in the progress of vascular complications. Formation of advanced glycation end products (AGEs) correlates with glycemic control. The AGE hypothesis proposes that hyperglycemia contributes to the pathogenesis of diabetic complications including retinopathy.
Yashodhara, Sharma, Sandeep, Saxena, Arvind, Mishra, Anita, Saxena, Shankar Madhav, Natu   +4 more
openaire   +2 more sources

Advanced Glycation End-products and Atherosclerosis

Annals of Medicine, 1996
The late rearrangements of the covalent nonenzymatic modification of proteins by glucose, called advanced glycation end-products (AGEs), have been shown to accumulate in diabetic and ageing tissues. AGEs elicit a wide range of cell-mediated responses leading to vascular dysfunction, matrix expansion and athero- and glomerulosclerosis.
openaire   +2 more sources

Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice [PDF]

, 2014
The reactive dicarbonyls, glyoxal and methylglyoxal (MG), increase in diabetes and may participate in the development of diabetic complications. Glyoxal and MG are detoxified by the sequential activities of glyoxalase 1 (GLO1) and glyoxalase 2.
Rabbani, Naila, Brownlee, M., Geoffrion, M., Courville, K., Du, X., Irshad, Zehra, Vanderhyden, B. C., Ott-Braschi, S., Sui, G., Thornalley, Paul J., Milne, R. W., D'Agati, V. D.   +11 more
core   +1 more source

Modifications of Lysine Residues 294 and 311 Within the Microtubule‐Binding Region Alter Tau Aggregation and Tubulin Binding Equilibria

Angewandte Chemie, EarlyView.
The molecular consequences of specific lysine modifications in Alzheimer´s disease remain insufficiently resolved in the context of full‐length protein. Here we integrate protein semisynthesis, segmental isotope labelling, and high‐resolution NMR spectroscopy to achieve residue‐resolved interrogation of site‐specific acetylation and carboxymethylation.
Dominik P. Vogl, Mario Migotti, Robert Konrat, Anne C. Conibear, Christian F. W. Becker   +4 more
wiley   +2 more sources

Advanced Glycation End Products and Inflammation in Type 1 Diabetes Development

, 2022
Type 1 diabetes (T1D) is an autoimmune disease in which the β-cells of the pancreas are attacked by the host’s immune system, ultimately resulting in hyperglycemia. It is a complex multifactorial disease postulated to result from a combination
Rani O. Whiddett, Whiddett, Rani O., Fotheringham, Amelia K, Chenping Du, Whiddett, Rani O, Chen Chen, Josephine M. Forbes, Du, Chenping, Chen, Chen, Buckle, Irina, Forbes, Josephine M, Fotheringham, Amelia K., Forbes, Josephine M., Irina Buckle, Amelia K. Fotheringham   +14 more
core   +1 more source