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Advanced Glycation End Products and Diabetic Nephropathy
American Journal of Therapeutics, 2005Chronic hyperglycemia and oxidative stress in diabetes results in the formation and accumulation advanced glycation end products (AGEs). AGEs have a wide range of chemical, cellular, and tissue effects that contribute to the development of microvascular complications. In particular, AGEs appear to have a key role in the diabetic nephropathy.
Merlin C, Thomas +2 more
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Advanced glycation end products and diabetic complications
Expert Opinion on Investigational Drugs, 2002Diabetic complications are major cause of morbidity and mortality in patients with diabetes. While the precise pathogenic mechanism(s) underlying conditions such as diabetic retinopathy, diabetic nephropathy and increased risk of atherosclerosis remain ill-defined, it is clear that hyperglycaemia is a primary factor that initiates and promotes ...
Stitt, Alan, Jenkins, A.J., Cooper, M.E.
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Advanced Glycation End Products in Renal Failure
Journal of Renal Nutrition, 2006Cellular and extracellular proteins suffer significant damage in vivo by glycation. Physiological proteolysis of proteins damaged by glycation forms glycation free adducts that are released into plasma for urinary excretion. Inefficient elimination of these free adducts in uremia leads to their accumulation.
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Advanced Glycation End Products and Cardiovascular Disease
Current Diabetes Reviews, 2008Cardiovascular disease (CVD) is the leading cause of mortality worldwide. Advanced glycation end products [AGEs] seem to play an important role for the development and/or progression of CVD mainly through induction of oxidative stress and inflammation.
Melpomeni, Peppa, Sotirios A, Raptis
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Mass spectrometry of advanced glycation end products
2005Mass spectrometry, in particular matrix assisted laser desorption/ionisation, is a powerful analytical tool in studies devoted to protein non-enzymatic glycation. It has been firstly tested on in vitro glycated proteins, and looking at the reliable results so obtained, on in vivo glycated proteins in population of healthy, well-controlled and badly ...
LAPOLLA, ANNUNZIATA, BASSO E., TRALDI P.
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Understanding RAGE, the receptor for advanced glycation end products
Journal of molecular medicine, 2005A. Bierhaus +7 more
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Advanced Glycation End Products: key player of the pathogenesis of atherosclerosis
Glycoconjugate Journal, 2022Sanjiv Singh +2 more
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Circulating tumor DNA in advanced solid tumors: Clinical relevance and future directions
Ca-A Cancer Journal for Clinicians, 2021Michael L Cheng +2 more
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