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Advanced glycation end products in uremia

Advances in Renal Replacement Therapy, 2003
The term "advanced glycation end products" (AGEs) stands for a heterogeneous group of amino acid derivatives that are formed via glycation processes between peptide-bound lysine or arginine derivatives and carbonyl compounds, processes originally known from food systems as "Maillard reactions." AGEs accumulate in plasma and tissues with advancing age ...
Thomas, Henle, Toshio, Miyata
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Advanced glycation and glycoxidation end products in bone

Bone, 2023
Hyperglycemia and oxidative stress, enhanced in diabetes and aging, result in excessive accumulation of advanced glycation and glycoxidation end products (AGEs/AGOEs) in bone. AGEs/AGOES are considered to be "the missing link" in explaining increased skeletal fragility with diabetes, aging, and osteoporosis where increased fracture risk cannot be ...
Bowen, Wang, Deepak, Vashishth
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Advanced glycation end products and the kidney

American Journal of Physiology-Renal Physiology, 2005
Advanced glycation end products (AGEs) are a heterogeneous group of protein and lipids to which sugar residues are covalently bound. AGE formation is increased in situations with hyperglycemia (e.g., diabetes mellitus) and is also stimulated by oxidative stress, for example in uremia.
Jürgen M, Bohlender   +3 more
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Advanced Glycation End Products and Diabetic Nephropathy

American Journal of Therapeutics, 2005
Chronic hyperglycemia and oxidative stress in diabetes results in the formation and accumulation advanced glycation end products (AGEs). AGEs have a wide range of chemical, cellular, and tissue effects that contribute to the development of microvascular complications. In particular, AGEs appear to have a key role in the diabetic nephropathy.
Thomas, Merlin C.   +2 more
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