Results 221 to 230 of about 58,432 (298)

Cardiac remodelling in type 2 diabetes: Pathophysiological mechanisms and opportunities for multiscale computational modelling and simulation

The Journal of Physiology, EarlyView.
Abstract figure legend Overview of multiscale cardiac remodelling in type 2 diabetes and how to model and simulate these changes using a human‐based, multiscale computational framework. Cardiac remodelling in type 2 diabetes occurs at ionic channel, protein, cellular, tissue and whole‐organ level, affecting the electrophysiological function, mechanical
Ambre Bertrand, Jakub Tomek, Blanca Rodriguez   +2 more
wiley   +1 more source

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Dual inhibition of heterocyclic amines and advanced glycation end-products by polymethoxyflavones via trapping reactive intermediates and scavenging free radicals. [PDF]

Curr Res Food Sci
Yang D, Deng P, Zhou Q, Gao F, Liu J, Xiao W, Zeng M, Quan W.   +7 more
europepmc   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Lack of receptor for advanced glycation end products attenuates obesity-induced adipose tissue senescence in mice. [PDF]

Adipocyte
Du Z, Wu J, Zhang T, Ma X, Li Z, Xu J, You J, Chen N, Wu J.   +8 more
europepmc   +1 more source

Caloric restriction and aerobic exercise differentially counteract muscle–tendon dysfunction following diet‐induced obesity in C57BL/6J mice

The Journal of Physiology, EarlyView.
Abstract figure legend Diet‐induced obesity induced fibro‐adipogenic remodelling of the muscle–tendon unit, characterized by increased fibrosis, reduced specific force, impaired relaxation kinetics, elevated hysteresis, and reduced aerobic capacity and glucose tolerance.
Leonardo Cesanelli, Petras Minderis, Andrej Fokin, Aivaras Ratkevicius, Ingrida Balnyte, Polzonetti Valeria, Tomas Venckunas, Cameron Hill, Danguole Satkunskiene, Hans Degens   +9 more
wiley   +1 more source

Multimatrix Detection and Quantification of the Advanced Glycation End Products Precursor Fructoselysine via UHPLC-HRMS/MS. [PDF]

Metabolites
Fenizia S, Manfredi M, Antoniotti V, Tini S, Baima J, Prodam F, Barberis E.   +6 more
europepmc   +1 more source

Increased CD44 Expression in Endothelial Cells Induced by Advanced Glycation End Products Leads to Insufficient Maturation of Angiogenesis. [PDF]

J Cell Mol Med
Huang X, Liu Z, Hu J, Li B, Chen Z, Zeng T, Zhou X, Lu R, Deng W, Zhou W, Huang Q.   +10 more
europepmc   +1 more source

Oxidative Stress‐Induced Expression Levels of PXDN and NF‐κB in Type 2 Diabetic Patients With Nephropathy

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 4, July 2026.
PXDN expression is markedly upregulated in diabetic nephropathy and, versus NF‐κB and oxidative stress markers, shows superior diagnostic performance (AUC 0.79; 90% specificity), supporting PXDN as a sensitive, specific non‐invasive biomarker for early DN.
Zakira Hanin, Aisha Anees Ahmed, Shuhd Salem Al Nahdi, Sumayya Althaf Kasim, Mahir Khalil Jallo, Rajaram Rhambau Jagdale, Dalia A. Gaber   +6 more
wiley   +1 more source

Current Developments in Analytical Methods for Advanced Glycation End Products in Foods. [PDF]

Molecules
Kataoka H.
europepmc   +1 more source